Institutt for klinisk medisin: Nye registreringer

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    • Norwegian Open Fracture Management System: Outcomes after 10 Years Working in Low-Resource Settings in Cambodian Hospitals 

      Tajsic, Nenad; Sørbye, Sigrunn Holbek; Nguon, Sophy; Sokh, Vannara; Lim, Aymeric (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-01-13)
      Introduction: The treatment of open lower limb fractures represents a major challenge for any trauma surgeon, and this even more so in resource-limited areas. The aim of the study is to describe the intervention, report the treatment plan, and observe the effectiveness of the Norwegian Open Fracture Management System in saving lower limbs in rural settings.<p> <p>Materials and Methods: A ...

    • Self-reported mental health status of pregnant women in Sweden during the COVID-19 pandemic: a cross-sectional survey 

      Ho-Fung, Chung; Andersson, Ewa; Hsuan-Ying, Huang; Acharya, Ganesh; Schwank, Simone (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-03-28)
      Background: The COVID-19 pandemic has contributed to unprecedented worries and challenges for pregnant women due to social restrictions and changes in maternity care provision. We aimed to investigate the mental health impact of COVID-19 pandemic on pregnant women in Sweden and explore factors associated with poor perinatal mental health in this specifc context.<p> <p>Method: This was a nation-wide ...

    • The association between preoperative MRI findings and clinical improvement in patients included in the NORDSTEN spinal stenosis trial 

      Aaen, Jørn Ståle; Banitalebi, Hasan; Austevoll, Ivar Magne; Hellum, Christian; Storheim, Kjersti; Myklebust, Tor Åge; Anvar, Masoud D; Weber, Clemens; Solberg, Tore; Grundnes, Oliver; Brisby, Helena; Indrekvam, Kari; Hermansen, Erland (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-08-05)
      <p><b>Purpose</b> To investigate potential associations between preoperative MRI findings and patient reported outcome measures (PROMs) after surgery for lumbar spinal stenosis (LSS). <p><b>Methods</b> The NORDSTEN trial included 437 patients. We investigated the association between preoperative MRI findings such as morphological grade of stenosis (Schizas grade), quantitative grade of ...

    • The relationship between smokeless tobacco (snus) and anxiety and depression among adults and elderly people. A comparison to smoking in the Tromsø Study 

      Bondø, Pia; Høye, Anne; Løchen, Maja-Lisa; Bramness, Jørgen Gustav (Journal article; Tidsskriftartikkel; Peer reviewed; Master thesis; Mastergradsoppgave, 2022-05-23)
      <p><b>Aims</b> To (i) define the characteristics of snus users compared with non-users and smokers and (ii) define the relationship between snus use and self-reported anxiety and depression and compare it with the relation between smoking and anxiety and depression. <p><b>Design, setting and participants</b> A cross-sectional study based on data from the Norwegian population-based survey, ...

    • Clinical improvement after surgery for degenerative cervical myelopathy; A comparison of Patient-Reported Outcome Measures during 12-month follow-up 

      Mjåset, Christer; Zwart, John Anker Henrik; Kolstad, Frode; Solberg, Tore; Grotle, Margreth (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-03-08)
      Object - Although many patients report clinical improvement after surgery due to degenerative cervical myelopathy, the aim of intervention is to stop progression of spinal cord dysfunction. We wanted to provide estimates and assess achievement rates of Minimal Clinically Important Difference (MCID) at 3- and 12-month follow-up for Neck Disability Index (NDI), Numeric Rating Scale for arm pain (NRS-AP) ...

    • Antirheumatic therapy is associated with reduced complement activation in rheumatoid arthritis 

      Nguyen, Thao; Hokstad, Ingrid; Fagerland, Morten; Mollnes, Tom Eirik; Hollan, Ivana; Feinberg, Mark W.; Hjeltnes, Gunnbjørg; Eilertsen, Gro Østli; Mikkelsen, Knut; Agewall, Stefan (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-02-25)
      Background The complement system plays an important role in pathophysiology of cardiovascular disease (CVD), and might be involved in accelerated atherogenesis in rheumatoid arthritis (RA). The role of complement activation in response to treatment, and in development of premature CVD in RA, is limited. Therefore, we examined the effects of methotrexate (MTX) and tumor necrosis factor inhibitors ...

    • Survival in Extreme Environments - Adaptation or Decompensation?, Volume 1 

      Tveita, Torkjel; Eftedal, Ingrid; Deb, Sanjoy Kumar (Book; Bok, 2022-02)

    • Health-related quality of life in young adults born small for gestational age: a prospective cohort study 

      Mehl, Cathrin Vano; Hollund, Ingrid Marie Husby; Iversen, Johanne Marie; Lydersen, Stian; Mork, Paul Jarle; Kajantie, Eero Olavi; Evensen, Kari Anne Indredavik (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-03-24)
      Background: Individuals born small for gestational age (SGA) have an increased risk of several adverse health outcomes, but their health-related quality of life (HRQoL) across young adulthood has yet to be studied. The main aim of this study was to investigate if being born SGA at term is associated with poor HRQoL at 32 years of age. A second aim was to explore longitudinal changes in HRQoL from ...

    • Stability evaluation of [ 18F]FDG: literature study, stability studies from two diferent PET centres and future recommendations 

      Holler, Jes Gitz; Renmælmo, Børge; Fjellaksel, Richard (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-02-24)
      Background: The need for a stability evaluation of [ <sup>18</sup>F]FDG is evident. The main purpose of this study was to make recommendations for determining the shelf life based on the available stability literature and our own two-centre stability studies.<p> <p>Results: We performed a non-systematic literature study to fnd the most relevant stability data for [ <sup>18</sup>F]FDG. The amount ...

    • Neonatal Impedance Cardiography in Asphyxiated Piglets-A Feasibility Study 

      Berisha, Gazmend; Solberg, Rønnaug; Klingenberg, Claus Andreas; Solevåg, Anne Lee (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-02-25)
      Objectives: Impedance cardiography (ICG) is a non-invasive method for continuous cardiac output measurement and has the potential to improve monitoring and treatment of sick neonates. PhysioFlow® is a signal-morphology ICG-system showing promising results in adults with low and high cardiac output, but no data from neonates or neonatal models exist. The aim of this study was to investigate PhysioFlow® ...

    • Barriers and opportunities to accessing social support in the transition from community to prison: A qualitative interview study with incarcerated individuals in Northern Norway 

      Solbakken, Line Elisabeth; Wynn, Rolf (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-07-28)
      Background: Incarcerated individuals have poor mental health compared to the general population. Social support has a benefcial efect on mental health. The bufering model proposes that social support facilitates coping under stressful conditions, while the main efects model suggests that belonging to social networks and having positive social interactions are benefcial for mental health. Prisons ...

    • Helicobacter pylori resistance to antibiotics before and after treatment: Incidence of eradication failure 

      Nestegard, Oddmund; Moayeri, Behrouz; Halvorsen, Fred-Arne; Tønnesen, Tor; Paulssen, Eyvind Jakob; Johnsen, Kay-Martin; Goll, Rasmus; Florholmen, Jon; Melby, Kjetil K. (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-04-20)
      Background <p>Increasing prevalence of antibiotic resistance especially to clarithromycin and metronidazole has been observed in Helicobacter pylori (H. pylori). <p>Aim <p>To characterize the antimicrobial resistance pattern of H. pylori before and after treatment in a cohort of patients accumulated over a period of 15 years after an unsuccessful eradication treatment had been given comparing ...

    • Cortical bone structure of the proximal femur and incident fractures 

      Nissen, Frida Igland; Andreasen, Camilla; Borgen, Tove Tveitan; Bjørnerem, Åshild Marit; Hansen, Ann Kristin (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-12-04)
      Purpose: Fracture risk is most frequently assessed using Dual X-ray absorptiometry to measure areal bone mineral density (aBMD) and using the Fracture Risk Assessment Tool (FRAX). However, these approaches have limitations and additional bone measurements may enhance the predictive ability of these existing tools. Increased cortical porosity has been associated with incident fracture in some ...

    • Divergent Regulation of Decidual Oxidative-Stress Response by NRF2 and KEAP1 in Preeclampsia with and without Fetal Growth Restriction 

      Mundal, Siv Boon; Rakner, Johanne Johnsen; Silva, Gabriela; Gierman, Lobke; Austdal, Marie; Basnet, Purusotam; Elschot, Mattijs; Bakke, Siril Skaret; Ostrop, Jenny; Thomsen, Liv Cecilie Vestrheim; Moses, Eric; Acharya, Ganesh; Bjørge, Line; Iversen, Ann-Charlotte (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-02-10)
      Utero-placental development in pregnancy depends on direct maternal–fetal interaction in the uterine wall decidua. Abnormal uterine vascular remodeling preceding placental oxidative stress and placental dysfunction are associated with preeclampsia and fetal growth restriction (FGR). Oxidative stress is counteracted by antioxidants and oxidative repair mechanisms regulated by the transcription factor ...

    • Effect of cigarette smoking on serum anti-Mullerian hormone and antral follicle count in women seeking fertility treatment: a prospective cross-sectional study 

      Bhide, Priya; Timlick, Elizabeth; Kulkarni, Abhijit; Gudi, Anil; Shah, Amit; Acharya, Ganesh (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-03-31)
      Objectives The relationship between smoking and ovarian reserve markers is inconclusive. The primary objective of our study was to assess the effect of cigarette smoking on the quantitative ovarian reserve parameters, serum anti-Mullerian hormone (AMH) and antral follicle count (AFC) as relevant to prediction of fertility outcomes in women seeking fertility treatment. Our secondary aims were ...

    • Expression of miR-24-1-5p in Tumor Tissue Influences Prostate Cancer Recurrence: The PROCA-life Study 

      Stikbakke, Einar; Wilsgaard, Tom; Haugnes, Hege Sagstuen; Pedersen, Mona Irene; Knutsen, Tore; Støyten, Martin; Giovannucci, Edward; Eggen, Anne Elise; Thune, Inger; Richardsen, Elin (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-02-23)
      The role of miR-24-1-5p and its prognostic implications associated with prostate cancer are mainly unknown. In a population-based cohort, the Prostate Cancer Study throughout life (PROCA-life), all men had a general health examination at study entry and were followed between 1994 and 2016. Patients with available tissue samples after a prostatectomy with curative intent were identified (n = 189). ...

    • Privacy-preserving audit and feedback on the antibiotic prescribing of General Practitioners 

      Yigzaw, Kassaye Yitbarek; Chomutare, Taridzo; Wynn, Rolf; Berntsen, Gro Karine Rosvold; Bellika, Johan Gustav (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-07-13)
      Background: Antibiotic resistance is a worldwide public health problem that is accelerated by the misuse and overuse of antibiotics. Studies have shown that audits and feedback enable clinicians to compare their personal clinical performance with that of their peers and are effective in reducing the inappropriate prescribing of antibiotics. However, privacy concerns make audits and feedback hard ...

    • Impact of liver fibrosis and clinical characteristics on dose-adjusted serum methadone concentrations 

      Chalabianloo, Fatemeh; Høiseth, Gudrun; Vold, Jørn Henrik; Johansson, Kjell Arne; Kringen, Marianne K.; Dalgard, Olav; Ohldieck, Christian; Druckrey-Fiskaaen, Karl Trygve; Aas, Christer Frode; Løberg, Else-Marie; Bramness, Jørgen Gustav; Fadnes, Lars T. (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-03-31)
      Background: There is limited knowledge on the causes of large variations in serum methadone concentrations and dose requirements. Objectives: We investigated the impact of the degree of liver fibrosis on dose-adjusted steady-state serum methadone concentrations.<p> <p<Methods: We assessed the clinical and laboratory data of 155 Norwegian patients with opioid use disorder undergoing methadone ...

    • Diagnostikk av øyeinfeksjoner. Strategimøte nr. 32, 2018 

      Brekke, Hanne; Romstad, Monica Regine; Stubhaug, Tore Taksdal; Åsheim, Sandra Elena; Mengshoel, Anne Torunn (Research report; Forskningsrapport, 2018-04)
      Det 32. Strategimøte i regi av Referansegruppen for eksterne kvalitetsvurderinger i bakteriologi, mykologi og parasittologi omhandlet øyeinfeksjoner og ble avholdt 31.10.2018 på Gjestehuset Lovisenberg i Oslo. På møtet deltok 40 personer fra 20 av landets medisinskmikrobiologiske laboratorier.<p> <p>Ansvarlig programkomité, som også har ferdigstilt denne avsluttende rapporten, var Hanne Brekke, ...

    • Behandling av muskelknuter i livmor: hurtigoversikt for samvalgsverktøy (oppdatering) 

      Holtet Evensen, Line (Research report; Forskningsrapport, 2022)
      Muskelknuter i livmoren består av en type muskelceller og bindevev som vokser på veggen i livmoren. Rundt åtte av ti kvinner har muskelknuter, og omtrent en tredjedel av disse får plagsomme symptomer.<p> <p>Vi fant én randomisert kontrollert studie og en metodevurdering om effekt av kombinasjonsbehandling med gonadotropinfrigjørende hormon-reseptorantagonist og to Cochrane-oversikter om ...