Institutt for klinisk medisin: Nye registreringer

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    • Recursive partitioning analysis of systemic therapy after radiotherapy in patients with brain metastases 

      Nieder, Carsten; Dalhaug, Astrid; Haukland, Ellinor Christin (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-03)
      Purpose: The purpose of this study was to identify factors associated with the initiation or continuation of systemic treatment after brain irradiation. The outcome of interest was a utilization rate of at least 75%, given that active extracranial disease is common in patients with brain metastases. If left untreated, extracranial disease limits survival, regardless of successful local treatment of ...

    • Prothrombotic genotypes and risk of venous thromboembolism in occult cancer 

      Skille, Hanne; Paulsen, Benedikte; Hveem, Kristian; Severinsen, Marianne T.; Gabrielsen, Maiken Elvestad; Kristensen, Søren R.; Næss, Inger Anne; Hindberg, Kristian; Tjønneland, Anne; Brækkan, Sigrid Kufaas; Hansen, John-Bjarne (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-07-01)
      Background - Studies have reported that the combination of some prothrombotic genotypes and overt cancer yields a synergistic effect on VTE risk. Whether individual prothrombotic genotypes or number of risk alleles in a genetic risk score (GRS) affect VTE risk in occult cancer have not been addressed. The aim of this study was to investigate the joint effect of five prothrombotic genotypes and occult ...

    • Peripheral chemoreflex activation and cardiac function during hypoxemia in near-term fetal sheep without placental compromise 

      Lantto, Juulia; Erkinaro, Tiina; Haapsamo, Mervi; Huhta, Heikki; Alanne, Leena; Kokki, Merja; Ohtonen, Pasi; Bhide, Amarnath; Acharya, Ganesh; Rasanen, Juha (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-11-09)
      A drop in arterial oxygen content activates fetal chemoreflex including an increase in sympathetic activity leading to peripheral vasoconstriction and redistribution of blood flow to protect the brain, myocardium, and adrenal glands. By using a chronically instrumented fetal sheep model with intact placental circulation at near-term gestation, we investigated the relationship between peripheral ...

    • Inntak av meieriprodukter og insidens av diabetes type 2 – en oversiktsartikkel 

      Sandnes, Frida Huhta; Hansson, Patrik (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-06)
      <p><i>Bakgrunn:</i> Det ses en økende forekomst av diabetes type 2 (T2D) i verden, og kostholdet er en av de viktigste modifiserbare risikofaktorene. Meieriprodukter er en stor kilde til mettede fettsyrer, som er en mulig risikofaktor for T2D. På den andre siden er det sett at flere enkeltnæringsstoffer i meieriprodukter kan virke forebyggende mot T2D. Denne oversiktsartikkelen oppsummerer litteratur ...

    • Xenotropic and polytropic retrovirus receptor 1 regulates procoagulant platelet polyphosphate 

      Mailer, Reiner K.; Allende, Mikel; Heestermans, Marco; Schweizer, Michaela; Deppermann, Carsten; Frye, Maike; Pula, Giordano; Odeberg, Jacob Olof; Gelderblom, Mathias; Rose-John, Stefan; Sickmann, Albert; Blankenberg, Stefan; Huber, Tobias B.; Kubisch, Christian; Maas, Coen; Gambaryan, Stepan; Firsov, Dmitri; Stavrou, Evi X.; Butler, Lynn; Renné, Thomas (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-09-15)
      Polyphosphate is a procoagulant inorganic polymer of linear-linked orthophosphate residues. Multiple investigations have established the importance of platelet polyphosphate in blood coagulation; however, the mechanistic details of polyphosphate homeostasis in mammalian species remain largely undefined. In this study, xenotropic and polytropic retrovirus receptor 1 (XPR1) regulated polyphosphate in ...

    • Performance of creatinine-based equations to estimate glomerular filtration rate with a methodology adapted to the context of drug dosage adjustment 

      Delanaye, Pierre; Björk, Jonas; Courbebaisse, Marie; Couzi, Lionel; Ebert, Natalie; Eriksen, Bjørn Odvar; Dalton, R. Neil; Dubourg, Laurence; Melsom, Toralf; Nyman, Ulf (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-10-28)
      <p><i>Aim:</i> The Cockcroft-Gault (CG) creatinine-based equation is still used to estimate glomerular filtration rate (eGFR) for drug dosage adjustment. Incorrect eGFR may lead to hazardous over- or underdosing. <p><i>Methods:</i> In a cross-sectional analysis, CG was validated against measured GFR (mGFR) in 14 804 participants and compared with the Modification-of-Diet-in-Renal-Diseases (MDRD), ...

    • Intraoperative swept-source OCT–based corneal topography for measurement and analysis of stromal surface after epithelial removal 

      Zhou, Wen; Reinstein, Dan Z.; Archer, Timothy J.; Chen, Xiangjun; Utheim, Tor Paaske; Feng, Yue; Stojanovic, Aleksandar (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-07-01)
      <p>PURPOSE: To assess intraoperative stromal topography measurements using swept-source optical coherence tomography (OCT)–based topography/tomography after epithelial removal and to analyze the epithelial contribution to the corneal topography and optics. <p>METHODS: This was a prospective series of 22 eyes of 19 patients referred to receive phototherapeutic keratotomy (PTK) for treatment of ...

    • Predicting self-injurious thoughts in daily life using ambulatory assessment of state cognition 

      Le, Thanh P.; Moscardini, Emma; Cowan, Tovah; Elvevåg, Brita; Holmlund, Terje Bektesevic; Foltz, Peter W.; Tucker, Raymond P.; Schwartz, Elana K.; Cohen, Alex S. (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-04-12)
      Self-injurious thoughts (SITs) fluctuate considerably from moment to moment. As such, “static” and temporally stable predictors (e.g., demographic variables, prior history) are suboptimal in predicting imminent SITs. This concern is particularly true for “online” cognitive abilities, which are important for understanding SITs, but are typically measured using tests selected for temporal stability. ...

    • The effect of train-the-colonoscopy-trainer course on colonoscopy quality indicators 

      Hoff, Geir; Botteri, Edoardo; Huppertz-Hauss, Gert; Kvamme, Jan-Magnus; Holme, Øyvind; Aabakken, Lars; Dahler, Stein; Medhus, Asle Wilhelm; Blomgren, Ingrid; Sandvei, Per; Darre-Næss, Ole; Kjellevold, Øystein; Seip, Birgitte Karen Berggreen (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-02-23)
      Background - Systematic training in colonoscopy is highly recommended; however, we have limited knowledge of the effects of “training-the-colonoscopy-trainer” (TCT) courses. Using a national quality register on colonoscopy performance, we aimed to evaluate the effects of TCT participation on defined quality indicators.<p> <p>Methods - This observational study compared quality indicators (pain, ...

    • Intramuscular uptake of tranexamic acid during haemorrhagic shock in a swine model 

      Bakke, Håkon Kvåle; Fuskevåg, Ole Martin; Nielsen, Erik Waage; Dietrichs, Erik Sveberg (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-12-18)
      Background: Tranexamic acid (TXA) reduce mortality in bleeding trauma patients, with greater efect if administered early. Serum concentrations above 10 µg/mL are considered sufcient to inhibit fbrinolysis. Normally administered intravenously (i.v.), TXA can also be administered intramuscularly (i.m.). This could be advantageous in low resource and military settings, if sufcient serum concentrations ...

    • Validation of a graded prognostic model in patients with brain metastases treated with whole-brain radiotherapy instead of radiosurgery 

      Nieder, Carsten; Mannsåker, Bård; Yobuta, Rosalba (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-05)
      Background/Aim: The aim of this study was to analyze the survival predictions obtained from a recent graded prognostic model developed and validated in Japan.<p><p> Patients and Methods: This was a retrospective single-institution analysis of 249 patients, managed with whole-brain radiotherapy for brain metastases. The sum of scores was calculated as in the Japanese study. The following parameters ...

    • Joint Effect of Multiple Prothrombotic Genotypes and Obesity on the Risk of Incident Venous Thromboembolism 

      Frischmuth, Tobias; Hindberg, Kristian; Gabrielsen, Maiken Elvestad; Brumpton, Ben Michael; Hveem, Kristian; Brækkan, Sigrid Kufaas; Hansen, John-Bjarne; Morelli, Vania Maris (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-05-03)
      <p><b>Background</b> The impact of the combination of obesity and multiple prothrombotic genotypes on venous thromboembolism (VTE) risk remains unclear. <p><b>Objective</b> To investigate the joint effect of obesity and a genetic risk score (GRS) composed of established prothrombotic single nucleotide polymorphisms (SNPs) on VTE risk using a population-based case–cohort. <p><b>Methods</b> Cases ...

    • Palliative radiotherapy during the last month of life: Have COVID-19 recommendations led to reduced utilization? 

      Nieder, Carsten; Haukland, Ellinor Christin; Mannsåker, Bård; Yobuta, Rosalba (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-01)
      Background/Aim: The study aimed to evaluate practice changes in the time period of the early wave of the COVID-19 pandemic. Patients and Methods: This was a retrospective single institution study. We defined palliative radiotherapy (PRT) initiated before Saturday, March 14th as pre-COVID and PRT initiated later as during-COVID (through June 30th). Results: National COVID-19 recommendations ...

    • Cerebroplacental ratio in predicting adverse perinatal outcome: a meta-analysis of individual participant data 

      Vollgraff Heidweiller-Schreurs, Heidweiller-Schreurs; van Osch, Osch; Heymans, Martijn W.; Ganzevoort, Wessel; Schoonmade, L.J.; Bax, C.J.; Mol, Ben W.; de Groot, Christianne J.M.; Bossuyt, Patrick M.M.; de Boer, Boer; Khalil, Asma; Thilaganathan, Basky; Turan, Ozhan M; Crimmins, Sarah; Harman, Chris; Shannon, Alisson M; Kumar, Sailesh; Dicker, Patrick; Malone, Fergal; Tully, Elizabeth C; Unterscheider, Julia; Crippa, Isabella; Ghidini, Alessandro; Roncaglia, Nadia; Vergani, Patrizia; Bhide, Amar; D'Antonio, Francesco; Pilu, Gianluigi; Galindo, Alberto; Herraiz, Ignacio; Vázquez-Sarandeses, Alicia; Ebbing, Cathrine; Johnsen, Synnøve Lian; Karlsen, Henriette Odland (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-05-03)
      Objective To investigate if cerebroplacental ratio (CPR) adds to the predictive value of umbilical artery pulsatility index (UA PI) alone – standard of practice – for adverse perinatal outcome in singleton pregnancies.<p> <p>Design and setting Meta-analysis based on individual participant data (IPD).<p> <p>Population or sample Ten centres provided 17 data sets for 21 661 participants, 18 731 ...

    • Elevated plasma D-dimer levels are associated with risk of future incident venous thromboembolism 

      Hansen, Ellen-Sofie; Rinde, Fridtjof Balteskard; Edvardsen, Magnus; Hindberg, Kristian; Latysheva, Nadezhda; Aukrust, Pål; Ueland, Thor; Michelsen, Annika Elisabet; Hansen, John Bjarne; Brækkan, Sigrid Kufaas; Morelli, Vania Maris (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-10-25)
      <p><i>Background</i> D-dimer, a global biomarker for activation of the coagulation and fibrinolysis systems, is useful in assessing individual risk of venous thromboembolism (VTE) recurrence. However, there is limited information on the association between D-dimer and risk of a first lifetime VTE event. <p><i>Objectives</i> To investigate the association between plasma D-dimer levels and risk of ...

    • The LabBM score is an excellent survival prediction tool in patients undergoing palliative radiotherapy 

      Nieder, Carsten; Dalhaug, Astrid; Haukland, Ellinor Christin (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-08-16)
      Background and aim: The prognostic assessment of patients referred for palliative radiotherapy can be conducted by sitespecific scores. A quick assessment that would cover the whole spectrum could simplify the working day of clinicians who are not specialists for a particular disease site. This study evaluated a promising score, the LabBM (validated for brain metastases), in patients treated for ...

    • Kennedy disease in two sisters with biallelic CAG expansions of the androgen receptor gene 

      Müller, Kai Ivar; Nilssen, Øivind; Nebuchenykh, Maria; Løseth, Sissel; Jonsrud, Christoffer; Hoem, Gry; Van Ghelue, Marijke; Arntzen, Kjell Arne (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-10-19)
      We present a retrospective 21-year follow-up of two sisters with X-linked biallelic CAG expansions in the androgen receptor (AR) gene causing Kennedy disease. Two sisters inherited CAG expansions from their mother who was a carrier and their father who had Kennedy disease. Genetic testing revealed alleles comprising 43/45, and 43/43 CAG repeats in the younger and older sister, respectively. They ...

    • No improvement of sleep from vitamin D supplementation: insights from a randomized controlled trial 

      Larsen, Anette Uhlving; Hopstock, Laila Arnesdatter; Jorde, Rolf; Grimnes, Guri (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-10-19)
      <i><p>Background</i> Vitamin D has been linked to sleep health in observational studies. Data from randomized controlled trials (RCTs) with vitamin D is scarce. <i><p>Methods</i> This study presents the results of a secondary analysis of 189 vitamin D insufficient participants (47.1% women) in a previously performed RCT, of which 92 were randomized to vitamin D (100,000 IU (2500 μg) as a ...

    • Randomized Trial of Interleukin-6 Receptor Inhibition in Patients With Acute ST-Segment Elevation Myocardial Infarction 

      Broch, Kaspar; Anstensrud, Anne Kristine; Woxholt, Sindre; Sharma, Kapil Kishore; Tøllefsen, Ingvild Maria; Bendz, Bjørn; Aakhus, Svend; Ueland, Thor; Amundsen, Brage H.; Damås, Jan Kristian; Berg, Erlend; Bjørkelund, Elisabeth; Bendz, Christina; Hopp, Einar; Kleveland, Ola; Stensæth, Knut Haakon; Opdahl, Anders; Kløw, Nils-Einar; Seljeflot, Ingebjørg; Andersen, Geir Øystein; Wiseth, Rune; Aukrust, Pål; Gullestad, Lars (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-04-12)
      <p><i>Background - </i>Prompt myocardial revascularization with percutaneous coronary intervention (PCI) reduces infarct size and improves outcomes in patients with ST-segment elevation myocardial infarction (STEMI). However, as much as 50% of the loss of viable myocardium may be attributed to the reperfusion injury and the associated inflammatory response. <p><i>Objectives - </i>This study sought ...

    • An artificial neural network approach integrating plasma proteomics and genetic data identifies PLXNA4 as a new susceptibility locus for pulmonary embolism 

      Razzaq, Misbah; Iglesias, Maria Jesus; Ibrahim-Kosta, Manal; Goumidi, Louisa; Soukarieh, Omar; Proust, Carole; Roux, Maguelonne; Suchon, Pierre; Boland, Anne; Daiain, Delphine; Olaso, Robert; Havervall, Sebastian; Thalin, Charlotte; Butler, Lynn; Deleuze, Jean-François; Odeberg, Jacob; Morange, Pierre-Emmanuel; Trégouët, David-Alexandre (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-07-07)
      Venous thromboembolism is the third common cardiovascular disease and is composed of two entities, deep vein thrombosis (DVT) and its potential fatal form, pulmonary embolism (PE). While PE is observed in~ 40% of patients with documented DVT, there is limited biomarkers that can help identifying patients at high PE risk. To fll this need, we implemented a two hidden-layers artifcial neural ...