Viser treff 661-680 av 1800

    • GARP promotes the proliferation and therapeutic resistance of bone sarcoma cancer cells through the activation of TGF-beta 

      Carrillo-Gálvez, Ana Belén; Quintero, Juan Esteban; Rodríguez, René; Menéndez, Sofía T.; González, M. Victoria; Blanco-Lorenzo, Verónica; Allonca, Eva; Farias, Virgínea de Araújo; González-Correa, Juan Elías; Erill-Sagalés, Nadina; Martínez-Zubiaurre, Iñigo; Hellevik, Turid; Sánchez-Hernández, Sabina; Muñoz, Pilar; Zurita, Federico; Martín, Francisco; Rodríguez-Manzaneque, Juan Carlos; Anderson, Per (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-11-17)
      Sarcomas are mesenchymal cancers with poor prognosis, representing about 20% of all solid malignancies in children, adolescents, and young adults. Radio- and chemoresistance are common features of sarcomas warranting the search for novel prognostic and predictive markers. GARP/LRRC32 is a TGF-β-activating protein that promotes immune escape and dissemination in various cancers. However, if GARP ...
    • Differences between Men and Women in Treatment and Outcome after Traumatic Brain Injury 

      Mikolic, Ana; van Klaveren, David; Oude Groeniger, Joost; Wiegers, E; Lingsma, Hester F; Zeldovich, Marina; von Steinbüchel, Nicole; Maas, Andrew I.R.; Roeters van Lennep, Jeanine; Polinder, Suzanne; Andelic, Nada; Andreassen, Lasse; Anke, Audny; Frisvold, Shirin; Helseth, Eirik; Røe, Cecilie; Røise, Olav; Skandsen, Toril; Vik, Anne; Åkerlund, Cecilia; Amrein, Krisztina (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-10-19)
      Traumatic brain injury (TBI) is a significant cause of disability, but little is known about sex and gender differences after TBI. We aimed to analyze the association between sex/gender, and the broad range of care pathways, treatment characteristics, and outcomes following mild and moderate/severe TBI. We performed mixed-effects regression analyses in the prospective multi-center Collaborative ...
    • Sigma-1 receptor positron emission tomography: A new molecular imaging approach using (S)-(-)-[18F]fluspidine in glioblastoma 

      Toussaint, Magali; Deuther-Conrad, Winnie; Kranz, Mathias; Fischer, Steffen; Ludwig, Friedrich-Alexander; Juratli, Tareq A.; Patt, Marianne; Wünsch, Bernhard; Schackert, Gabriele; Sabri, Osama; Brust, Peter (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-05-06)
      Glioblastoma multiforme (GBM) is the most devastating primary brain tumour characterised by infiltrative growth and resistance to therapies. According to recent research, the sigma-1 receptor (sig1R), an endoplasmic reticulum chaperone protein, is involved in signaling pathways assumed to control the proliferation of cancer cells and thus could serve as candidate for molecular characterisation of ...
    • Prehospital tourniquets in civilians: A systematic review 

      Eilertsen, Kenneth A.; Winberg, Morten; Jeppesen, Elisabeth; Hval, Gyri; Wisborg, Torben (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-11-03)
      Objectives: Terrorist attacks and civilian mass-casualty events are frequent, and some countries have implemented tourniquet use for uncontrollable extremity bleeding in civilian settings. The aim of this study was to summarize current knowledge on the use of prehospital tourniquets to assess whether their use increases the survival rate in civilian patients with life-threatening hemorrhages from ...
    • Are the Relationships of Lean Mass and Fat Mass With Bone Microarchitecture Causal or Due to Familial Confounders? A Novel Study of Adult Female Twin Pairs 

      Bui, Minh; Zebaze, Roger; Li, Shuai; Hopper, John L.; Bjørnerem, Åshild (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-07-01)
      It is not known whether the relationships of lean mass (LM) and fat mass (FM) with bone microarchitecture and geometry are causal and/or are because of confounders, including familial confounders arising from genetic and environment effects shared by relatives. We tested the hypotheses that: (i) LM is associated with cortical bone traits, (ii) FM is associated with trabecular bone traits, and (iii) ...
    • Evaluating a centralised cancer support centre in the remote region of Northern Norway 

      Ervik, Bente; Andersen, Sigve; Skirbekk, Helge; Dønnem, Tom (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-09-20)
      Introduction: Being diagnosed with cancer and undergoing treatment is a life-changing experience, and many cancer patients find the physical, emotional and social effects of the disease to be stressful. This study explores the experiences of cancer patients and their relatives from all parts of Northern Norway visiting the centralised cancer support centre. <p> <p>Methods: In a comprehensive ...
    • Choice of immunoassay to evaluate porcine cytokine levels 

      Ueland, Nora Lamark; Ludvigsen, Judith K.; Hellerud, Bernt C; Mollnes, Tom Eirik; Skjeflo, Espen Waage (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-10-06)
      <i>Background</i> - In order to adequately monitor cytokines in experimental models, currently available methods and commercially available kits should be compared.<br><br> <i>Aim</i> - To compare the plasma and tissue concentrations of IL-1β, IL-6, IL-8, IL-10, and TNF as a measure of systemic inflammation in septic pigs.<br><br> <i>Methods</i> - Cytokines were quantified from blood and tissue ...
    • STudy of Antithrombotic Treatment after IntraCerebral Haemorrhage: Protocol for a randomised controlled trial 

      Larsen, Kristin Tveitan; Forfang, Elisabeth; Pennlert, Johanna; Glader, Eva-Lotta; Kruuse, Christina; Wester, Per; Ihle-Hansen, Hege; Carlsson, Maria; Berge, Eivind; Al-Shahi Salman, Rustam; Wyller, Torgeir Bruun; Rønning, Ole M. (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-09-03)
      Background and aims - Many patients with prior intracerebral haemorrhage have indications for antithrombotic treatment with antiplatelet or anticoagulant drugs for prevention of ischaemic events, but it is uncertain whether such treatment is beneficial after intracerebral haemorrhage. STudy of Antithrombotic Treatment after IntraCerebral Haemorrhage will assess (i) the effects of long-term antithrombotic ...
    • Intestinal inflammatory profile shows increase in a diversity of biomarkers in irritable bowel syndrome 

      Berg, Leif Kyrre; Goll, Rasmus; Fagerli, Erik; Ludviksen, Judith K; Fure, Hilde; Odd Sverre, Moen; Sørbye, Sveinung; Mollnes, Tom Eirik; Florholmen, Jon (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-04-24)
      Background: It has been proposed that irritable bowel syndrome (IBS) is a low-grade mucosal inflammatory disease. <p> <p>Objective: To characterize the intestinal inflammatory profile in IBS patients with or without fructose intolerance.<p> <p>Design: Patients referred to colonoscopy with IBS complaints were screened for participation. IBS patients diagnosed according to the Rome II criteria ...
    • Tracking of serum 25-hydroxyvitamin D during 21 years 

      Kubiak, Julia Magdalena; Kamycheva, Elena; Jorde, Rolf (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-12-11)
      Background/objectives - Our objective was to evaluate the degree of tracking for serum levels of 25-hydroxyvitamin D [25(OH)D] over time, by using data from three previously conducted surveys of the Tromsø study collected in the years 1994/1995 (Tromsø 4), 2007/2008 (Tromsø 6), and 2015/2016 (Tromsø 7).<p> <p>Subjects/methods - Subjects with valid 25(OH)D measurements in all three surveys were ...
    • Provider decision regret - a useful method for analysis of palliative thoracic re-irradiation for lung cancer? 

      Nieder, Carsten; Mannsåker, Bård; Yobuta, Rosalba; Haukland, Ellinor Christin (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-01-30)
      Background - The overall usefulness of palliative thoracic re-irradiation depends on the balance between efficacy, survival, and toxicity, and is difficult to judge from previous studies. In the absence of patient-reported data, we developed a method for provider decision regret that addresses the question “would we re-irradiate this patient again in light of the known outcome?” Furthermore, we ...
    • Symptom burden in patients with oligometastases at the start of palliative radiotherapy 

      Nieder, Carsten; Kämpe, Thomas A (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-03-04)
      Background/Aim: Recent studies suggested that patients with oligometastases have a better prognosis compared with those who have widespread dissemination. In both groups, radiotherapy is a commonly applied treatment. Patient-reported symptoms might depend on the burden of disease. Possibly, oligometastatic patients report lower scores for symptoms, such as fatigue or reduced appetite, which tend to ...
    • Long-term survival results after treatment for oligometastatic brain disease 

      Nieder, Carsten; Hintz, Mandy; Popp, Ilinca; Bilger, Angelika; Grosu, Anca L. (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-03-04)
      Aim - The aim of this study was to characterize the survival results of patients with up to four brain metastases after intense local therapy (primary surgery or stereotactic radiotherapy) if extracranial metastases were absent or limited to one site, e.g. the lungs.<p> <p>Background - Oligometastatic disease has repeatedly been reported to convey a favorable prognosis.<p> <p>Material and ...
    • Direct angiography demonstrates equal 8-12 years patency rates of radial artery and saphenous vein grafts 

      Bahar, Ramez; Dahl-Eriksen, Øystein; Busund, Rolf; Dahl, Per Erling; Hermansen, Stig Eggen; Iqbal, Amjid; Mannsverk, Jan; Myrmel, Truls; Steigen, Terje; Trovik, Thor; Sørlie, Dag Glen; Bartnes, Kristian (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-06-30)
      Objectives: The benefits of coronary artery bypass surgery depend on lasting graft patency. To aid rational graft selection, the relative long-term merits of radial artery and saphenous vein grafts need to be determined by a gold standard method and with minimal clinically driven selection bias. Methods: The patency rates of various conduits were determined by direct angiography in 76 patients from ...
    • No significant histological or ultrastructural tendinosis changes in the hamstring tendon in patients with mild to moderate osteoarthritis of the knee? 

      Ibrahim, Mustafa; Meknas, Khaled; Steigen, Sonja Eriksson; Olsen, Randi; Sernert, Ninni; Ejerhed, Lars ERik; Kartus, Jüri-Tomas (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-06-05)
      Purpose - To investigate the periarticular degenerative changes of the knee joint in association with osteoarthritis (OA). More tendinosis was expected to be found in the semitendinosus tendon in patients with knee OA than in patients without knee OA.<p> <p>Methods - Samples from 41 patients were included between January 2016 and October 2017. Twenty-one patients median age 53 (33–63) years with ...
    • Atrial fibrillation, venous thromboembolism, ischemic stroke, and all-cause mortality: The Tromsø study 

      Hald, Erin Mathiesen; Løchen, Maja-Lisa; Mathiesen, Ellisiv B; Wilsgaard, Tom; Njølstad, Inger; Brækkan, Sigrid K.; Hansen, John-Bjarne (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-07-06)
      Background Atrial fibrillation (AF) is associated with increased risk of ischemic stroke and all‐cause mortality. Patients with AF are also at increased risk of venous thromboembolism (VTE), but information on how AF impacts VTE‐related mortality is scarce. Objectives - To investigate the impact of AF on all‐cause mortality in subjects with and without a thromboembolic event (VTE or ischemic ...
    • D-dimer as a stand-alone test to rule out deep vein thrombosis 

      Rinde, Fridtjof Balteskard; Frønæs, Synne Grønvold; Ghanima, Waleed Khalid; Vik, Anders; Hansen, John-Bjarne; Brækkan, Sigrid (Journal article; Tidsskriftartikkel, 2020-04-25)
      Background - Current guidelines recommend the use of clinical decision rules, such as Wells score, in combination with D-dimer to assess the need for objective imaging to rule out deep vein thrombosis (DVT). However, the clinical decision rule has limitations, and use of D-dimer as a stand-alone test has been suggested.<p> <p>Objective - We aimed to assess the safety and efficiency of D-dimer as ...
    • The fraction of lung cancer attributable to smoking in the Norwegian Women and Cancer (NOWAC) Study 

      Hansen, Merethe Selnes; Licaj, Idlir; Braaten, Tonje; Lund, Eiliv; Gram, Inger Torhild (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-10-27)
      <i>Background</i> - We examined the association between active and passive smoking and lung cancer risk and the population attributable fraction (PAF) of lung cancer due to active smoking, in the Norwegian Women and Cancer Study, a nationally representative prospective cohort study.<br><br> <i>Methods</i> - We followed 142,508 women, aged 31–70 years, who completed a baseline questionnaire between ...
    • Leisure physical exercise and creatine kinase activity. The Tromsø study 

      Bekkelund, Svein Ivar (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-08-16)
      Creatine kinase (CK) is an enzyme catalyzing energy reaction in muscle cells and has proven to modify cardiovascular risks. The influence of skeletal muscle activity on CK concentrations is a potential study confounder but is mainly reported in connection with sport activities. This study investigated the association between leisure physical exercise and CK and estimated the effect of physical ...
    • Management strategies for children with COVID-19: ESPR practical recommendations 

      Raissaki, Maria; Shelmerdine, Susan; Damasio, Beatrice; Toso, Seema; Kvist, Ola; Lovrenski, Jovan; Hirsch, Franz Wolfgang; Görkem, Süreyya Burcu; Paterson, Anne; Arthurs, Owen J.; Rossi, Andrea; van Schuppen, Joost; Petit, Philippe; Argyropoulou, Maria I.; Offiah, Amaka C.; Rosendahl, Karen; Caro-Domínguez, Pablo (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-07-03)
      During the outbreak of the COVID-19 pandemic, guidelines have been issued by international, national and local authorities to address management and the need for preparedness. Children with COVID-19 differ from adults in that they are less often and less severely affected. Additional precautions required in the management of children address their increased radiosensitivity, need for accompanying ...