<i>Background</i> - Prestatin trials reported positive effects of omega-3 polyunsaturated fatty acids (n-3 PUFA) in cardiovascular disease, whereas recent studies and meta-analyses have not reproduced these results. The effect of n-3 PUFA in patients with familial hypercholesterolemia (FH), a group with particularly high risk of cardiovascular disease, is not well established.<p><p> <i>Objective</i> ...

Background/Aim: Endometrial hyperplastic polyps (EHP) may progress to endometrial carcinoma (EC) if left untreated. We aimed to prospectively investigate the efficacy of the low-dose levonorgestrel intrauterine system (LNG-IUS) as therapy for EHP with malignant potential. Patients and Methods: In total, 37 women with EHP underwent therapy with LNG-IUS containing 13.5 mg levonorgestrel for six months ...

<i>Aim</i> - Long‐term evaluations of childhood obesity treatments are needed. We examined changes in weight and cardiometabolic risk 1 year after children completed individual family or group‐based weight management interventions.<p><p> <i>Methods</i> - In 2009‐2010, 6‐ to 12‐year‐old children with overweight or obesity from Finnmark and Troms (Norway) were recruited after media coverage and ...

<i>Background</i> - Positron emission tomography (PET)/magnetic resonance (MR) imaging may become increasingly important for assessing tumor therapy response. A prerequisite for quantitative PET/MR imaging is reliable and repeatable MR-based attenuation correction (AC).<p> <p><i>Purpose</i> - To investigate the frequency and test–retest reproducibility of artifacts in MR-AC maps in a lung cancer ...

<i>Objective</i> - To assess the reliability of lumbar facet arthropathy evaluation with computed tomography (CT) or magnetic resonance imaging (MRI) in patients with and without lumbar disc prosthesis and to estimate the reliability for individual CT and MRI findings indicating facet arthropathy.<p> <p><i>Methods</i> - Metal-artifact reducing CT and MRI protocols were performed at follow-up of ...

<i>Introduction</i> - Low birthweight is associated with diseases later in life. The mechanisms for these associations are not well known. If the hypothesis concerning “maternal constraint” is correct for humans, as shown in animal experiments, we expect the maternal, not paternal, body proportions to influence antenatal growth and those of both parents to influence postnatal growth. We aimed to ...

<i>Background</i> - Cardiorespiratory fitness (CRF) is a strong predictor of future arterial cardiovascular disease and premature mortality. However, there are limited data on the association between CRF and the risk of incident venous thromboembolism (VTE).<p><p> <i>Objectives</i> - To investigate whether estimated CRF (eCRF) was associated with the risk of incident VTE in a cohort recruited ...

<i>Background</i> - Health registries may yield important data for epidemiological studies. However, in order to be a valuable source for information, the registered data have to be correct.<p><p> <i>Objectives</i> - The aim of the study was to validate data from the Norwegian Patient Registry (NPR) regarding multiple sclerosis (MS).<p><p> <i>Materials and Methods</i> - We obtained data ...

Mutations in genes encoding K_ATP channel subunits have been reported for pancreatic disorders and Cantú syndrome. Here, we report a syndrome in six patients from two families with a consistent phenotype of mild intellectual disability, similar facies, myopathy, and cerebral white matter hyperintensities, with cardiac systolic dysfunction present in the two oldest patients. Patients are ...

Paracrine and endocrine roles have increasingly been ascribed to extracellular vesicles (EVs) generated by multicellular organisms. Central to the biogenesis, content, and function of EVs are their delimiting lipid bilayer membranes. To evaluate research progress on membranes and EVs, the International Society for Extracellular Vesicles (ISEV) conducted a workshop in March 2018 in Baltimore, Maryland, ...