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dc.contributor.authorGiambelluca, Miriam Soledad
dc.contributor.authorMarkova, Elena
dc.contributor.authorLouet, Claire
dc.contributor.authorSteinkjer, Bjørg
dc.contributor.authorSundset, Rune
dc.contributor.authorSkalko Basnet, Natasa
dc.contributor.authorHak, Sjoerd
dc.date.accessioned2024-01-12T20:28:40Z
dc.date.available2024-01-12T20:28:40Z
dc.date.issued2023-10-20
dc.description.abstractNanomedicine holds immense potential for therapeutic manipulation of phagocytic immune cells. However, in vitro studies often fail to accurately translate to the complex in vivo environment. To address this gap, we employed an ex vivo human whole-blood assay to evaluate liposome interactions with immune cells. We systematically varied liposome size, PEG-surface densities and sphingomyelin and ganglioside content. We observed differential uptake patterns of the assessed liposomes by neutrophils and monocytes, emphasizing the importance of liposome design. Interestingly, our results aligned closely with published in vivo observations in mice and patients. Moreover, liposome exposure induced changes in cytokine release and cellular responses, highlighting the potential modulation of immune system. Our study highlights the utility of human whole-blood models in assessing nanoparticle-immune cell interactions and provides insights into liposome design for modulating immune responses.en_US
dc.identifier.citationGiambelluca, Markova, Louet, Steinkjer, Sundset, Skalko Basnet, Hak. Liposomes - Human phagocytes interplay in whole blood: effect of liposome design. Nanomedicine: Nanotechnology, Biology and Medicine. 2023;54en_US
dc.identifier.cristinIDFRIDAID 2189908
dc.identifier.doi10.1016/j.nano.2023.102712
dc.identifier.issn1549-9634
dc.identifier.issn1549-9642
dc.identifier.urihttps://hdl.handle.net/10037/32473
dc.language.isoengen_US
dc.publisherElsevieren_US
dc.relation.journalNanomedicine: Nanotechnology, Biology and Medicine
dc.relation.projectIDNorges forskningsråd: 223255en_US
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2023 The Author(s)en_US
dc.rights.urihttps://creativecommons.org/licenses/by/4.0en_US
dc.rightsAttribution 4.0 International (CC BY 4.0)en_US
dc.titleLiposomes - Human phagocytes interplay in whole blood: effect of liposome designen_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US


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Attribution 4.0 International (CC BY 4.0)
Except where otherwise noted, this item's license is described as Attribution 4.0 International (CC BY 4.0)