Global Effect of Modifiable Risk Factors on Cardiovascular Disease and Mortality.
dc.contributor.author | Magnussen, Christina | |
dc.contributor.author | Ojeda, Francisco M. | |
dc.contributor.author | Leong, Darryl P. | |
dc.contributor.author | Alegre-Diaz, Jesus | |
dc.contributor.author | Amouyel, Philippe | |
dc.contributor.author | Aviles-Santa, Larissa | |
dc.contributor.author | De Bacquer, Dirk | |
dc.contributor.author | Ballantyne, Christie M. | |
dc.contributor.author | Bernabé-Ortiz, Antonio | |
dc.contributor.author | Bobak, Martin | |
dc.contributor.author | Brenner, Hermann | |
dc.contributor.author | Carrillo-Larco, Rodrigo M. | |
dc.contributor.author | De Lemos, James | |
dc.contributor.author | Dobson, Annette | |
dc.contributor.author | Dörr, Marcus | |
dc.contributor.author | Donfrancesco, Chiara | |
dc.contributor.author | Drygas, Wojciech | |
dc.contributor.author | Dullaart, Robin P. | |
dc.contributor.author | Engström, Gunnar | |
dc.contributor.author | Ferrario, Marco M. | |
dc.contributor.author | Ferrières, Jean | |
dc.contributor.author | De Gaetano, Giovanni | |
dc.contributor.author | Goldbourt, Uri | |
dc.contributor.author | Gonzalez, Clicerio | |
dc.contributor.author | Grassi, Guido | |
dc.contributor.author | Hodge, Allison M. | |
dc.contributor.author | Hveem, Kristian | |
dc.contributor.author | Iacoviello, Licia | |
dc.contributor.author | Ikram, M. Kamran | |
dc.contributor.author | Irazola, Vilma | |
dc.contributor.author | Jobe, Modou | |
dc.contributor.author | Jousilahti, Pekka | |
dc.contributor.author | Kaleebu, Pontiano | |
dc.contributor.author | Kavousi, Maryam | |
dc.contributor.author | Kee, Frank | |
dc.contributor.author | Khalili, Davood | |
dc.contributor.author | Koenig, Wolfgang | |
dc.contributor.author | Kontsevaya, Anna | |
dc.contributor.author | Kuulasmaa, Kari | |
dc.contributor.author | Lackner, Karl J. | |
dc.contributor.author | Leistner, David M. | |
dc.contributor.author | Lind, Lars | |
dc.contributor.author | Linneberg, Allan | |
dc.contributor.author | Lorenz, Thiess | |
dc.contributor.author | Lyngbakken, Magnus Nakrem | |
dc.contributor.author | Malekzadeh, Reza | |
dc.contributor.author | Malyutina, Sofia | |
dc.contributor.author | Mathiesen, Ellisiv B. | |
dc.contributor.author | Melander, Olle | |
dc.contributor.author | Metspalu, Andres | |
dc.contributor.author | Miranda, J. Jaime | |
dc.contributor.author | Moitry, Marie | |
dc.contributor.author | Mugisha, Joseph | |
dc.contributor.author | Nalini, Mahdi | |
dc.contributor.author | Nambi, Vijay | |
dc.contributor.author | Ninomiya, Toshiharu | |
dc.contributor.author | Oppermann, Karen | |
dc.contributor.author | D'Orsi, Eleonora | |
dc.contributor.author | Pająk, Andrzej | |
dc.contributor.author | Palmieri, Luigi | |
dc.contributor.author | Panagiotakos, Demosthenes | |
dc.contributor.author | Perianayagam, Arokiasamy | |
dc.contributor.author | Peters, Annette | |
dc.contributor.author | Poustchi, Hossein | |
dc.contributor.author | Prentice, Andrew M. | |
dc.contributor.author | Prescott, Eva | |
dc.contributor.author | Risérus, Ulf | |
dc.contributor.author | Salomaa, Veikko | |
dc.contributor.author | Sans, Susana | |
dc.contributor.author | Sakata, Satoko | |
dc.contributor.author | Schöttker, Ben | |
dc.contributor.author | Schutte, Aletta E. | |
dc.contributor.author | Sepanlou, Sadaf G. | |
dc.contributor.author | Sharma, Sanjib Kumar | |
dc.contributor.author | Shaw, Jonathan E. | |
dc.contributor.author | Simons, Leon A. | |
dc.contributor.author | Söderberg, Stefan | |
dc.contributor.author | Tamosiunas, Abdonas | |
dc.contributor.author | Thorand, Barbara | |
dc.contributor.author | Tunstall-Pedoe, Hugh | |
dc.contributor.author | Twerenbold, Raphael | |
dc.contributor.author | Vanuzzo, Diego | |
dc.contributor.author | Veronesi, Giovanni | |
dc.contributor.author | Waibel, Julia | |
dc.contributor.author | Wannamethee, S. Goya | |
dc.contributor.author | Watanabe, Masafumi | |
dc.contributor.author | Wild, Philipp S. | |
dc.contributor.author | Yao, Yao | |
dc.contributor.author | Zeng, Yi | |
dc.contributor.author | Ziegler, Andreas | |
dc.contributor.author | Blankenberg, Stefan | |
dc.date.accessioned | 2024-01-22T10:03:10Z | |
dc.date.available | 2024-01-22T10:03:10Z | |
dc.date.issued | 2023 | |
dc.description.abstract | BACKGROUND - Five modifiable risk factors are associated with cardiovascular disease and death from any cause. Studies using individual-level data to evaluate the regional and sex-specific prevalence of the risk factors and their effect on these outcomes are lacking.<p> <p>METHODS - We pooled and harmonized individual-level data from 112 cohort studies conducted in 34 countries and 8 geographic regions participating in the Global Cardiovascular Risk Consortium. We examined associations between the risk factors (body-mass index, systolic blood pressure, non–high-density lipoprotein cholesterol, current smoking, and diabetes) and incident cardiovascular disease and death from any cause using Cox regression analyses, stratified according to geographic region, age, and sex. Population-attributable fractions were estimated for the 10-year incidence of cardiovascular disease and 10-year all-cause mortality.<p> <p>RESULTS - Among 1,518,028 participants (54.1% of whom were women) with a median age of 54.4 years, regional variations in the prevalence of the five modifiable risk factors were noted. Incident cardiovascular disease occurred in 80,596 participants during a median follow-up of 7.3 years (maximum, 47.3), and 177,369 participants died during a median follow-up of 8.7 years (maximum, 47.6). For all five risk factors combined, the aggregate global population-attributable fraction of the 10-year incidence of cardiovascular disease was 57.2% (95% confidence interval [CI], 52.4 to 62.1) among women and 52.6% (95% CI, 49.0 to 56.1) among men, and the corresponding values for 10-year all-cause mortality were 22.2% (95% CI, 16.8 to 27.5) and 19.1% (95% CI, 14.6 to 23.6).<p> <p>CONCLUSIONS - Harmonized individual-level data from a global cohort showed that 57.2% and 52.6% of cases of incident cardiovascular disease among women and men, respectively, and 22.2% and 19.1% of deaths from any cause among women and men, respectively, may be attributable to five modifiable risk factors. (Funded by the German Center for Cardiovascular Research (DZHK); ClinicalTrials.gov number, NCT05466825. opens in new tab.) | en_US |
dc.identifier.citation | Magnussen, Ojeda, Leong, Alegre-Diaz, Amouyel, Aviles-Santa, De Bacquer, Ballantyne, Bernabé-Ortiz, Bobak, Brenner, Carrillo-Larco, De Lemos, Dobson, Dörr, Donfrancesco, Drygas, Dullaart, Engström, Ferrario, Ferrières, De Gaetano, Goldbourt, Gonzalez, Grassi, Hodge, Hveem, Iacoviello, Ikram, Irazola, Jobe, Jousilahti, Kaleebu, Kavousi, Kee, Khalili, Koenig, Kontsevaya, Kuulasmaa, Lackner, Leistner, Lind, Linneberg, Lorenz, Lyngbakken, Malekzadeh, Malyutina, Mathiesen, Melander, Metspalu, Miranda, Moitry, Mugisha, Nalini, Nambi, Ninomiya, Oppermann, D'Orsi, Pająk, Palmieri, Panagiotakos, Perianayagam, Peters, Poustchi, Prentice, Prescott, Risérus, Salomaa, Sans, Sakata, Schöttker, Schutte, Sepanlou, Sharma, Shaw, Simons, Söderberg, Tamosiunas, Thorand, Tunstall-Pedoe, Twerenbold, Vanuzzo, Veronesi, Waibel, Wannamethee, Watanabe, Wild, Yao, Zeng, Ziegler, Blankenberg. Global Effect of Modifiable Risk Factors on Cardiovascular Disease and Mortality.. New England Journal of Medicine. 2023;389(14):1273-1285 | en_US |
dc.identifier.cristinID | FRIDAID 2216132 | |
dc.identifier.doi | 10.1056/NEJMoa2206916 | |
dc.identifier.issn | 0028-4793 | |
dc.identifier.issn | 1533-4406 | |
dc.identifier.uri | https://hdl.handle.net/10037/32657 | |
dc.language.iso | eng | en_US |
dc.publisher | Massachusetts Medical Society | en_US |
dc.relation.journal | New England Journal of Medicine | |
dc.rights.accessRights | openAccess | en_US |
dc.rights.holder | Copyright 2023 The Author(s) | en_US |
dc.title | Global Effect of Modifiable Risk Factors on Cardiovascular Disease and Mortality. | en_US |
dc.type.version | publishedVersion | en_US |
dc.type | Journal article | en_US |
dc.type | Tidsskriftartikkel | en_US |
dc.type | Peer reviewed | en_US |