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dc.contributor.authorGil-Lespinard, Mercedes
dc.contributor.authorAlmanza-Aguilera, Enrique
dc.contributor.authorCastañeda, Jazmín
dc.contributor.authorGuiñón-Fort, Daniel
dc.contributor.authorEriksen, Anne Kirstine
dc.contributor.authorTjønneland, Anne
dc.contributor.authorRothwell, Joseph A.
dc.contributor.authorShah, Sanam
dc.contributor.authorCadeau, Claire
dc.contributor.authorKatzke, Verena
dc.contributor.authorJohnson, Theron
dc.contributor.authorSchulze, Matthias B.
dc.contributor.authorOliverio, Andreina
dc.contributor.authorPasanisi, Fabrizio
dc.contributor.authorTumino, Rosario
dc.contributor.authorManfredi, Luca
dc.contributor.authorMasala, Giovana
dc.contributor.authorSkeie, Guri
dc.contributor.authorLundblad, Marie Wasmuth
dc.contributor.authorBrustad, Magritt
dc.contributor.authorLasheras, Cristina
dc.contributor.authorCrous-Bou, Marta
dc.contributor.authorMolina-Montes, Esther
dc.contributor.authorColorado-Yohar, Sandra
dc.contributor.authorGuevara, Marcela
dc.contributor.authorAmiano, Pilar
dc.contributor.authorJohansson, Ingegerd
dc.contributor.authorHultdin, Johan
dc.contributor.authorForouhi, Nita G.
dc.contributor.authorFreisling, Heinz
dc.contributor.authorMerdas, Mira
dc.contributor.authorDebras, Charlotte
dc.contributor.authorHeath, Alicia K.
dc.contributor.authorAglago, Elom K.
dc.contributor.authorAune, Dagfinn
dc.contributor.authorZamora-Ros, Raul
dc.date.accessioned2024-08-26T13:16:45Z
dc.date.available2024-08-26T13:16:45Z
dc.date.issued2024-01-25
dc.description.abstractIntroduction: Dietary intake of (poly)phenols has been linked to reduced adiposity and body weight (BW) in several epidemiological studies. However, epidemiological evidence on (poly)phenol biomarkers, particularly plasma concentrations, is scarce. We aimed to investigate the associations between plasma (poly)phenols and prospective BW change in participants from the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. <p> <p>Methods: This study included 761 participants with data on BW at baseline and after 5 years of follow-up. Plasma concentrations of 36 (poly)phenols were measured at baseline using liquid chromatography-tandem mass spectrometry. Associations were assessed through general linear mixed models and multinomial logistic regression models, using change in BW as a continuous or as a categorical variable (BW loss, maintenance, gain), respectively. Plasma (poly)phenols were assessed as log2-transformed continuous variables. The false discovery rate (FDR) was used to control for multiple comparisons. <p> <p>Results: Doubling plasma (poly)phenol concentrations showed a borderline trend towards a positive association with BW loss. Plasma vanillic acid showed the strongest association (−0.53 kg/5 years; 95% confidence interval [CI]: −0.99, −0.07). Similar results were observed for plasma naringenin comparing BW loss versus BW maintenance (odds ratio: 1.1; 95% CI: 1.0, 1.2). These results did not remain significant after FDR correction. <p> <p>Conclusion: Higher concentrations of plasma (poly)phenols suggested a tendency towards 5-year BW maintenance or loss. While certain associations seemed promising, they did not withstand FDR correction, indicating the need for caution in interpreting these results. Further studies using (poly)phenol biomarkers are needed to confirm these suggestive protective trends.en_US
dc.identifier.citationGil-Lespinard, Almanza-Aguilera, Castañeda, Guiñón-Fort, Eriksen, Tjønneland, Rothwell, Shah, Cadeau, Katzke, Johnson, Schulze, Oliverio, Pasanisi, Tumino, Manfredi, Masala, Skeie, Lundblad, Brustad, Lasheras, Crous-Bou, Molina-Montes, Colorado-Yohar, Guevara, Amiano, Johansson, Hultdin, Forouhi, Freisling, Merdas, Debras, Heath, Aglago, Aune, Zamora-Ros. Plasma Concentration of 36 (Poly)phenols and Prospective Body Weight Change in Participants from the EPIC Cohort. Annals of Nutrition and Metabolism. 2024;80(2):87-100
dc.identifier.cristinIDFRIDAID 2264881
dc.identifier.doi10.1159/000535803
dc.identifier.issn0250-6807
dc.identifier.issn1421-9697
dc.identifier.urihttps://hdl.handle.net/10037/34423
dc.language.isoengen_US
dc.publisherKarger Publishersen_US
dc.relation.journalAnnals of Nutrition and Metabolism
dc.rights.holderCopyright 2024 The Author(s)en_US
dc.rights.urihttps://creativecommons.org/licenses/by/4.0en_US
dc.rightsAttribution 4.0 International (CC BY 4.0)en_US
dc.titlePlasma Concentration of 36 (Poly)phenols and Prospective Body Weight Change in Participants from the EPIC Cohorten_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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Attribution 4.0 International (CC BY 4.0)
Except where otherwise noted, this item's license is described as Attribution 4.0 International (CC BY 4.0)