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dc.contributor.authorTøndel, Birgitte Gladsø
dc.contributor.authorSejrup, Joakim Knutsen
dc.contributor.authorMorelli, Vania Maris
dc.contributor.authorLøchen, Maja-Lisa
dc.contributor.authorNjølstad, Inger
dc.contributor.authorMathiesen, Ellisiv B.
dc.contributor.authorWilsgaard, Tom
dc.contributor.authorHansen, John Bjarne
dc.contributor.authorBrækkan, Sigrid Kufaas
dc.date.accessioned2024-08-29T09:51:25Z
dc.date.available2024-08-29T09:51:25Z
dc.date.issued2024-03-27
dc.description.abstractBackground: Patients with ischemic stroke have increased risk of venous thromboembolism (VTE). Obesity is prevalent in stroke patients and a well-established risk factor for VTE. Whether obesity further increases the VTE risk in patients with stroke remains unclear.<p> <p>Objectives: We investigated the joint effect of ischemic stroke and obesity on the risk of incident VTE in a population-based cohort. <p>Methods: Participants (n = 29,920) were recruited from the fourth to sixth surveys of the Tromsø Study (1994-1995, 2001, and 2007-2008) and followed through 2014. Incident events of ischemic stroke and VTE during follow-up were recorded. Hazard ratios (HRs) of VTE with 95% CIs were estimated according to combined categories of ischemic stroke and obesity (body mass index ≥ 30 kg/m<sup>2</sup> ), with exposure to neither risk factors as reference. <p>Results: During a median follow-up of 19.6 years, 1388 participants experienced ischemic stroke and 807 participants developed VTE. Among those with stroke, 51 developed VTE, yielding an incidence rate of VTE after stroke of 7.2 per 1000 personyears (95% CI, 5.5-9.5). In subjects without stroke, obesity was associated with a 1.8- fold higher VTE risk (HR, 1.76; 95% CI, 1.47-2.11). In nonobese subjects, stroke was associated with a 1.8-fold higher VTE risk (HR, 1.77; 95% CI, 1.27-2.46). Obese subjects with stroke had a 2-fold increased VTE risk (HR, 2.44; 95% CI, 1.37-4.36). <p>Conclusion: The combination of obesity and ischemic stroke did not yield an excess risk of VTE. Our findings suggest that obese subjects with ischemic stroke do not have a more than additive risk of VTE.en_US
dc.identifier.citationTøndel, Sejrup, Morelli, Løchen, Njølstad, Mathiesen, Wilsgaard, Hansen, Brækkan. Joint effect of ischemic stroke and obesity on the risk of venous thromboembolism: the Tromsø Study. Research and Practice in Thrombosis and Haemostasis (RPTH). 2024;8(3)en_US
dc.identifier.cristinIDFRIDAID 2266166
dc.identifier.doi10.1016/j.rpth.2024.102392
dc.identifier.issn2475-0379
dc.identifier.urihttps://hdl.handle.net/10037/34461
dc.language.isoengen_US
dc.publisherElsevieren_US
dc.relation.journalResearch and Practice in Thrombosis and Haemostasis (RPTH)
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2024 The Author(s)en_US
dc.rights.urihttps://creativecommons.org/licenses/by/4.0en_US
dc.rightsAttribution 4.0 International (CC BY 4.0)en_US
dc.titleJoint effect of ischemic stroke and obesity on the risk of venous thromboembolism: the Tromsø Studyen_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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Attribution 4.0 International (CC BY 4.0)
Med mindre det står noe annet, er denne innførselens lisens beskrevet som Attribution 4.0 International (CC BY 4.0)