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dc.contributor.authorWagner, Theresa Maria
dc.contributor.authorPöntinen, Anna Kaarina
dc.contributor.authorFenzel, Carolin Kornelia
dc.contributor.authorEngi, Daniel
dc.contributor.authorJanice, Jessin
dc.contributor.authorAlmeida-Santos, Ana C.
dc.contributor.authorTedim, Ana P.
dc.contributor.authorFreitas, Ana R.
dc.contributor.authorPeixe, Luísa
dc.contributor.authorvan Schaik, Willem
dc.contributor.authorJohannessen, Mona Susan
dc.contributor.authorHegstad, Kristin
dc.date.accessioned2024-09-10T07:43:10Z
dc.date.available2024-09-10T07:43:10Z
dc.date.issued2024-03-09
dc.description.abstractEnterococcus faecium (Efm) is a versatile pathogen, responsible for multidrug-resistant infections, especially in hospitalized immuno compromised patients. Its population structure has been characterized by diverse clades (A1, A2, and B (reclassified as E. lactis (Ela)), adapted to different environments, and distinguished by their resistomes and virulomes. These features only partially explain the predominance of clade A1 strains in nosocomial infections. We investigated in vitro interaction of 50 clinical isolates (clade A1 Efm) against 75 commensal faecal isolates from healthy humans (25 clade A2 Efm and 50 Ela). Only 36% of the commensal isolates inhibited clinical isolates, while 76% of the clinical isolates inhibited commensal isolates. The most apparent overall differences in inhibition patterns were presented between clades. The inhibitory activity was mainly mediated by secreted, proteinaceous, heat-stable compounds, likely indicating an involvement of bacteriocins. A custom-made database targeting 76 Bacillota bacteriocins was used to reveal bacteriocins in the genomes. Our systematic screening of the interactions between nosocomial and commensal Efm and Ela on a large scale suggests that, in a clinical setting, nosocomial strains not only have an advantage over commensal strains due to their possession of AMR genes, virulence factors, and resilience but also inhibit the growth of commensal strains.en_US
dc.identifier.citationWagner, Pöntinen, Fenzel, Engi, Janice, Almeida-Santos, Tedim, Freitas, Peixe, van Schaik, Johannessen, Hegstad. Interactions between commensal Enterococcus faecium and Enterococcus lactis and clinical isolates of Enterococcus faecium. FEMS microbes. 2024;5en_US
dc.identifier.cristinIDFRIDAID 2267001
dc.identifier.doi10.1093/femsmc/xtae009
dc.identifier.issn2633-6685
dc.identifier.urihttps://hdl.handle.net/10037/34640
dc.language.isoengen_US
dc.publisherOxford University Pressen_US
dc.relation.journalFEMS microbes
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2024 The Author(s)en_US
dc.rights.urihttps://creativecommons.org/licenses/by/4.0en_US
dc.rightsAttribution 4.0 International (CC BY 4.0)en_US
dc.titleInteractions between commensal Enterococcus faecium and Enterococcus lactis and clinical isolates of Enterococcus faeciumen_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


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Attribution 4.0 International (CC BY 4.0)
Except where otherwise noted, this item's license is described as Attribution 4.0 International (CC BY 4.0)