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dc.contributor.authorRaju, Sajan
dc.contributor.authorMolinaro, Antonio
dc.contributor.authorAwoyemi, Ayodeji Olawale
dc.contributor.authorJørgensen, Silje Fjellgård
dc.contributor.authorBraadland, Peder Rustøen
dc.contributor.authorNendl, Andraz
dc.contributor.authorSeljeflot, Ingebjørg
dc.contributor.authorUeland, Per Magne
dc.contributor.authorMcCann, Adrian
dc.contributor.authorAukrust, Pål
dc.contributor.authorVestad, Beate
dc.contributor.authorMayerhofer, Christiane Caroline
dc.contributor.authorBroch, Kaspar
dc.contributor.authorGullestad, Lars
dc.contributor.authorLappegård, Knut Tore
dc.contributor.authorHalvorsen, Bente
dc.contributor.authorKristiansen, Karstein Berge
dc.contributor.authorHov, Johannes Espolin Roksund
dc.contributor.authorTrøseid, Marius
dc.date.accessioned2024-09-10T10:32:10Z
dc.date.available2024-09-10T10:32:10Z
dc.date.issued2024-02-08
dc.description.abstract<p><i>Background</i> Interactions between the gut microbiota, diet, and host metabolism contribute to the development of cardiovascular disease, but a firm link between disease-specific gut microbiota alterations and circulating metabolites is lacking. <p><i>Methods</i> We performed shot-gun sequencing on 235 samples from 166 HF patients and 69 healthy control samples. Separate plasma samples from healthy controls (n = 53) were used for the comparison of imidazole propionate (ImP) levels. Taxonomy and functional pathways for shotgun sequencing data was assigned using MetaPhlAn3 and HUMAnN3 pipelines. <p><i>Results</i> Here, we show that heart failure (HF) is associated with a specific compositional and functional shift of the gut microbiota that is linked to circulating levels of the microbial histidine-derived metabolite ImP. Circulating ImP levels are elevated in chronic HF patients compared to controls and associated with HF-related gut microbiota alterations. Contrary to the microbiota composition, ImP levels provide insight into etiology and severity of HF and also associate with markers of intestinal permeability and systemic inflammation. <p><i>Conclusions</i> Our findings establish a connection between changes in the gut microbiota, the presence, etiology, and severity of HF, and the gut-microbially produced metabolite ImP. While ImP appears promising as a circulating biomarker reflecting gut dysbiosis related to HF, further studies are essential to demonstrate its causal or contributing role in HF pathogenesis.en_US
dc.identifier.citationRaju, Molinaro, Awoyemi, Jørgensen, Braadland, Nendl, Seljeflot, Ueland, McCann, Aukrust, Vestad, Mayerhofer, Broch, Gullestad, Lappegård, Halvorsen, Kristiansen, Hov, Trøseid. Microbial-derived imidazole propionate links the heart failure-associated microbiome alterations to disease severity. Genome Medicine. 2024;16(1):27en_US
dc.identifier.cristinIDFRIDAID 2250121
dc.identifier.doi10.1186/s13073-024-01296-6
dc.identifier.issn1756-994X
dc.identifier.urihttps://hdl.handle.net/10037/34652
dc.language.isoengen_US
dc.publisherSpringer Natureen_US
dc.relation.journalGenome Medicine
dc.relation.projectIDinfo:eu-repo/grantAgreement/EC/H2020/802544/EU/Recurrent disease in the liver transplant: window to identify and stop gut signals driving autoimmunity/StopAutoimmunity/en_US
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2024 The Author(s)en_US
dc.rights.urihttps://creativecommons.org/licenses/by/4.0en_US
dc.rightsAttribution 4.0 International (CC BY 4.0)en_US
dc.titleMicrobial-derived imidazole propionate links the heart failure-associated microbiome alterations to disease severityen_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US


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Attribution 4.0 International (CC BY 4.0)
Med mindre det står noe annet, er denne innførselens lisens beskrevet som Attribution 4.0 International (CC BY 4.0)