Show simple item record

dc.contributor.authorBjerring, Anders W.
dc.contributor.authorSmeland, Knut Bjøro
dc.contributor.authorStokke, Thomas Muri
dc.contributor.authorHaugaa, Kristina Ingrid Helena Hermann
dc.contributor.authorHolte, Espen
dc.contributor.authorRösner, Assami
dc.contributor.authorKiserud, Cecilie E.
dc.contributor.authorEdvardsen, Thor
dc.contributor.authorSarvari, Sebastian
dc.date.accessioned2024-09-11T11:45:40Z
dc.date.available2024-09-11T11:45:40Z
dc.date.issued2024-04-04
dc.description.abstractBackground Hodgkin’s lymphoma (HL) is a hematological malignancy that affects both children and young adults. Traditional treatment is associated with a life-time prevalence of cardiac disease exceeding 50%. In the late 1990s protocols were modified to reduce cancer therapy-related adverse cardiac effects. This study aimed to assess the long-term impact of advances in treatment protocols on the cardiac health of HL survivors (HLS).<p> <p>Methods HLS (n=246) treated between 1997 and 2007 with anthracycline-based chemotherapy in three centers in Norway were included. Of these, 132 (53%) had also received mediastinal radiotherapy. HLS were compared to controls (n=58) recruited from the general population and matched for sex, age, smoking status, and heredity for coronary artery disease. All subjects underwent echocardiography, clinical assessment, and blood sampling. <p>Results The HLS were 46±9 years old and had been treated 17±3 years before inclusion in the study. There was no significant difference between HLS and controls in ejection fraction (EF) (58%±5 vs. 59%±4, p=0.08) or prevalence of heart failure. HLS treated with both anthracyclines and mediastinal radiotherapy (AC+MRT) had slightly worse left ventricular global longitudinal strain than controls (-19.3±2.5% vs. -20.8±2.0%, p<0.001), but those treated with only anthracyclines did not. HLS treated with AC+MRT had a higher prevalence of valve disease than those treated only with anthracyclines (12% vs. 4%, p<0.05). <p>Conclusions HLS treated with anthracyclines after the late 1990s have similar cardiac function and morphology as age-matched controls, apart from higher rates of valvular disease in those who also underwent mediastinal radiotherapy.en_US
dc.identifier.citationBjerring, Smeland, Stokke, Haugaa, Holte, Rösner, Kiserud, Edvardsen, Sarvari. Long-term cardiac effects of modern treatment for Hodgkin’s lymphoma. Cardio-Oncology. 2024;10(1)en_US
dc.identifier.cristinIDFRIDAID 2263922
dc.identifier.doi10.1186/s40959-024-00222-4
dc.identifier.issn2057-3804
dc.identifier.urihttps://hdl.handle.net/10037/34689
dc.language.isoengen_US
dc.publisherBMCen_US
dc.relation.journalCardio-Oncology
dc.rights.accessRightsopenAccessen_US
dc.rights.holderCopyright 2024 The Author(s)en_US
dc.rights.urihttps://creativecommons.org/licenses/by/4.0en_US
dc.rightsAttribution 4.0 International (CC BY 4.0)en_US
dc.titleLong-term cardiac effects of modern treatment for Hodgkin’s lymphomaen_US
dc.type.versionpublishedVersionen_US
dc.typeJournal articleen_US
dc.typeTidsskriftartikkelen_US
dc.typePeer revieweden_US


File(s) in this item

Thumbnail

This item appears in the following collection(s)

Show simple item record

Attribution 4.0 International (CC BY 4.0)
Except where otherwise noted, this item's license is described as Attribution 4.0 International (CC BY 4.0)