A comprehensive review of monkeypox virus and mpox characteristics
Permanent lenke
https://hdl.handle.net/10037/34737Dato
2024-03-06Type
Journal articleTidsskriftartikkel
Peer reviewed
Forfatter
Alakunle, Emmanuel; Kolawole, Daniel; Diaz Cánova, Diana Karina; Alele, Faith; Adegboye, Oyelola; Moens, Ugo; Okeke, malachy ifeanyiSammendrag
Monkeypox virus (MPXV) is the etiological agent of monkeypox (mpox), a
zoonotic disease. MPXV is endemic in the forested regions of West and Central
Africa, but the virus has recently spread globally, causing outbreaks in multiple
non-endemic countries. In this paper, we review the characteristics of the virus,
including its ecology, genomics, infection biology, and evolution. We estimate by
phylogenomic molecular clock that the B.1 lineage responsible for the 2022
mpox outbreaks has been in circulation since 2016. We interrogate the host-virus
interactions that modulate the virus infection biology, signal transduction,
pathogenesis, and host immune responses. We highlight the changing
pathophysiology and epidemiology of MPXV and summarize recent advances
in the prevention and treatment of mpox. In addition, this review identifies
knowledge gaps with respect to the virus and the disease, suggests future
research directions to address the knowledge gaps, and proposes a One
Health approach as an effective strategy to prevent current and future
epidemics of mpox.
Forlag
Frontiers MediaSitering
Alakunle, Kolawole, Diaz Cánova, Alele, Adegboye, Moens, Okeke. A comprehensive review of monkeypox virus and mpox characteristics. Frontiers in Cellular and Infection Microbiology. 2024;14Metadata
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