SLE: a cognitive step forward—a synthesis of rethinking theories, causality, and ignored DNA structures
Permanent lenke
https://hdl.handle.net/10037/34790Dato
2024-06-04Type
Journal articleTidsskriftartikkel
Peer reviewed
Forfatter
Rekvig, Ole PetterSammendrag
Systemic lupus erythematosus (SLE) is classified by instinctual classification
criteria. A valid proclamation is that these formally accepted SLE classification
criteria legitimate the syndrome as being difficult to explain and therefore
enigmatic. SLE involves scientific problems linked to etiological factors and
criteria. Our insufficient understanding of the clinical condition uniformly
denoted SLE depends on the still open question of whether SLE is, according
to classification criteria, a well-defined one disease entity or represents a variety
of overlapping indistinct syndromes. Without rational hypotheses, these
problems harm clear definition(s) of the syndrome. Why SLE is not anchored in
logic, consequent, downstream interdependent and interactive inflammatory
networks may rely on ignored predictive causality principles. Authoritative
classification criteria do not reflect consequent causality criteria and do not
unify characterization principles such as diagnostic criteria. We need now to
reconcile legendary scientific achievements to concretize the delimitation of
what SLE really is. Not all classified SLE syndromes are “genuine SLE”; many are
theoretically “SLE-like non-SLE” syndromes. In this study, progressive theories
imply imperative challenges to reconsider the fundamental impact of “the
causality principle”. This may offer us logic classification and diagnostic criteria
aimed at identifying concise SLE syndromes as research objects. Can a systems
science approach solve this problem?
Forlag
Frontiers MediaSitering
Rekvig. SLE: a cognitive step forward—a synthesis of rethinking theories, causality, and ignored DNA structures. Frontiers in Immunology. 2024;15Metadata
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