dc.contributor.author | Skhvitaridze, Natia | |
dc.contributor.author | Gamkrelidze, Amiran | |
dc.contributor.author | Manjavidze, Tinatin | |
dc.contributor.author | Brenn, Tormod Ola | |
dc.contributor.author | Rylander, Karin Charlotta Maria | |
dc.date.accessioned | 2024-09-23T08:47:47Z | |
dc.date.available | 2024-09-23T08:47:47Z | |
dc.date.issued | 2024-02-22 | |
dc.description.abstract | Background Georgia experienced an increase in maternal deaths (MD) during the severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) pandemic, which warrants further investigation. This study aimed to assess
associations between timing of SARS-CoV-2 infection during pregnancy and MD, post-delivery intensive care unit
(ICU) admission, and caesarean section (CS) delivery.<p>
<p>Methods We performed a national birth registry-based cohort study of pregnant women who had completed
22 weeks of gestation and delivered between February 28, 2020, and August 31, 2022. The data were linked to
coronavirus disease 2019 (COVID-19) testing, vital, and immunization registries. Pregnant women were classified into
three groups: confirmed SARS-CoV-2 infection from conception through 31 days before delivery; confirmed infection
within 30 days before or at delivery; and women negative for SARS-CoV-2 infection or without any test results
(reference group). Multivariable logistic regression was used to calculate the adjusted odds ratios (aORs) and 95%
confidence intervals (CIs).
<p>Results Among 111,493 pregnant women, 16,751 had confirmed infection during pregnancy, and 7,332 were fully
vaccinated against COVID-19 before delivery. Compared to the reference group, those with confirmed infection
within 30 days before or at delivery experienced increased odds of MD (aOR: 43.11, 95% CI, 21.99–84.55), post-delivery
ICU admission (aOR: 5.20, 95% CI, 4.05–6.67), and CS delivery (aOR: 1.11, 95% CI, 1.03–1.20).
<p>Conclusions Pregnant women in Georgia with confirmed SARS-CoV-2 infection within 30 days before or at delivery
experienced a considerably higher risk of MD and post-delivery ICU admission and a slightly higher risk for CS delivery.
Additionally, the results highlighted that most pregnant women were not vaccinated against COVID-19. These
findings should alert stakeholders that adherence to public health preventive measures needs to be improved. | en_US |
dc.identifier.citation | Skhvitaridze, Gamkrelidze, Manjavidze, Brenn, Rylander. SARS-CoV-2 infection during pregnancy and the risk of adverse maternal outcomes in the Republic of Georgia: a national birth registry-based cohort study. BMC Pregnancy and Childbirth. 2024;24(1) | |
dc.identifier.cristinID | FRIDAID 2260275 | |
dc.identifier.doi | 10.1186/s12884-024-06329-x | |
dc.identifier.issn | 1471-2393 | |
dc.identifier.uri | https://hdl.handle.net/10037/34822 | |
dc.language.iso | eng | en_US |
dc.publisher | BMC | en_US |
dc.relation.ispartof | Skhvitaridze, N. (2024). Maternal death and maternal morbidity in Georgia. (Doctoral thesis). <a href=https://hdl.handle.net/10037/34961>https://hdl.handle.net/10037/34961</a>. | |
dc.relation.journal | BMC Pregnancy and Childbirth | |
dc.rights.holder | Copyright 2024 The Author(s) | en_US |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0 | en_US |
dc.rights | Attribution 4.0 International (CC BY 4.0) | en_US |
dc.title | SARS-CoV-2 infection during pregnancy and the risk of adverse maternal outcomes in the Republic of Georgia: a national birth registry-based cohort study | en_US |
dc.type.version | publishedVersion | en_US |
dc.type | Journal article | en_US |
dc.type | Tidsskriftartikkel | en_US |
dc.type | Peer reviewed | en_US |