Merkel Cell Polyomavirus in the Context of Oral Squamous Cell Carcinoma and Oral Potentially Malignant Disorders
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https://hdl.handle.net/10037/34919Dato
2024-03-22Type
Journal articleTidsskriftartikkel
Peer reviewed
Forfatter
Passerini, Sara; Babini, Giulia; Merenda, Elisabetta; Carletti, Raffaella; Scribano, Daniela; Rosa, Luigi; Conte, Antonietta Lucia; Moens, Ugo; Ottolenghi, Livia; Romeo, Umberto; Conte, Maria Pia; Di Gioia, Cira Rosaria Tiziana; Pietropaolo, ValeriaSammendrag
Despite recent advances in prevention, detection and treatment, oral squamous cell carcinoma (OSCC) remains a global health concern, strongly associated with environmental and lifestyle
risk factors and infection with oncogenic viruses. Merkel Cell Polyomavirus (MCPyV), well known
to be the causative agent of Merkel Cell Carcinoma (MCC) has been found in OSCC, suggesting its
potential role as a co-factor in the development of oral cavity cancers. To improve our understanding
about MCPyV in oral cavities, the detection and analysis of MCPyV DNA, transcripts and miRNA
were performed on OSCCs and oral potentially malignant disorders (OPMDs). In addition, the
cellular miR-375, known to be deregulated in tumors, was examined. MCPyV DNA was found in
3 out of 11 OSCC and 4 out of 12 OPMD samples, with a viral mean value of 1.49 × 102
copies/mL.
Viral integration was not observed and LTAg and VP1 transcripts were detected. Viral miRNAs were
not detected whereas the cellular miR-375 was found over expressed in all MCPyV positive oral
specimens. Our results reported evidence of MCPyV replication in both OSCC and OPMD suggesting
the oral cavity as a site of replicative MCPyV infection, therefore underscoring an active role of this
virus in the occurrence of oral lesions.
Forlag
MDPISitering
Passerini, Babini, Merenda, Carletti, Scribano, Rosa, Conte, Moens, Ottolenghi, Romeo, Conte, Di Gioia, Pietropaolo. Merkel Cell Polyomavirus in the Context of Oral Squamous Cell Carcinoma and Oral Potentially Malignant Disorders. Biomedicines. 2024;12(4)Metadata
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Copyright 2024 The Author(s)