Post-Conization HPV Vaccination and Its Impact on Viral Status: A Retrospective Cohort Study in Troms and Finnmark, 2022
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https://hdl.handle.net/10037/35006Dato
2024-05-02Type
Journal articleTidsskriftartikkel
Peer reviewed
Sammendrag
Human papillomavirus (HPV) is associated with cellular changes in the cervix leading to
cancer, which highlights the importance of vaccination in preventing HPV infections and subsequent
cellular changes. Women undergoing the loop electrosurgical excision procedure (LEEP), a treatment
for high-grade cervical intraepithelial neoplasia (CIN2+), remain at risk of recurrence. This study
assessed the effect of post-conization HPV vaccination on the viral status of women at six months
post-conization, aiming to evaluate the vaccine’s effectiveness in preventing recurrence of CIN2+. A
retrospective cohort study was conducted among women in Troms and Finnmark who underwent
conization in 2022. Using the SymPathy database and the national vaccination register (SYSVAK),
we analyzed the vaccination statuses and HPV test results of women born before 1991, who had not
received the HPV vaccine prior to conization. Out of 419 women undergoing conization, 243 met
the inclusion criteria. A significant association was found between post-conization HPV vaccination
and a negative HPV test at six months of follow-up (ARR = 12.1%, p = 0.039). Post-conization HPV
vaccination significantly reduced the risk of a positive HPV test at the first follow-up, suggesting its
potential in preventing the recurrence of high-grade cellular changes. However, the retrospective
design and the insufficient control of confounding variables in this study underscore the need for
further studies to confirm these findings.
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MDPISitering
Rykkelid, Wennberg, Richardsen, Sørbye. Post-Conization HPV Vaccination and Its Impact on Viral Status: A Retrospective Cohort Study in Troms and Finnmark, 2022. Pathogens. 2024;13(5)Metadata
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