Merkel cell polyomavirus (MCPyV) is the major cause of Merkel cell carcinoma (MCC), an aggressive skin cancer. MCPyV large T-antigen (LTag) and small T-antigen (sTag) are the main oncoproteins involved in MCPyV-induced MCC. A hallmark of MCPyV-positive MCC cells is the expression of a C-terminal truncated LTag. Protein kinase A (PKA) plays a fundamental role in a variety of biological processes, ...

The primary goal of large-scale electronic health record (EHR) suites is to meet the needs of a broad range of users in healthcare institutions. EHR suites are extensively configurable, which makes it possible to tailor them to diverse professional practices and users. However, while users such as physicians and nurses may have clearly defined responsibilities, clerical personnel (i.e. secretaries) ...

In this thesis, it was investigated whether mothers` EMSs would predict maternal-fetal bonding quality during pregnancy (paper 1), whether attachment style would be associated with mother-infant bonding quality after birth (paper 2), and if these relations were mediated by symptoms of depression (paper 1) and parenting stress (paper 2). EMSs and anxious and avoidant attachment styles may be thought ...

Aims: The aim of this study was to investigate the age-varying mortality risk associated with different labour market status categories.<p> <p>Methods: Data from a population-based survey carried out among adults aged 30–62 years in Finnmark in 1987/1988 were linked to the Norwegian Cause of Death Registry to identify all deaths occurring by December 2017. We used flexible parametric survival ...

The aim of this paper is to explore how practical knowledge can enhance higher education and Bildung for the human service professions. The paper sheds light on how governance reforms such as New Public Management have influenced higher education, where we argue that scientific rationality has weakened the professional’s autonomy and responsibility. The paper is based on the three authors’ experiences ...

Colorectal cancer is the third most common cancer worldwide, and rectal carcinoma represents about 25% of the cases. Surgical removal of the tumor is the standard curative treatment, and during the last decades the survival rates have improved through both better surgical methods and the introduction of radiochemotherapy. There is, however, still an ongoing debate on which treatment offers the best ...

Background Cancer survivors are a diverse group with varying needs that are patient-, disease-, and/or treatmentspecific. Cancer survivors have reported supplementing conventional anti-cancer treatment with Traditional and Complementary Medicine (T&CM). Although female cancer survivors are reported to have more severe anticancer adverse effects, little is known about the association between ...

Bacterial biofilms are highly protected surface attached communities of bacteria that typically cause chronic infections. To address their recalcitrance to antibiotics and minimise side effects of current therapies, smart drug carriers are being explored as promising platforms for antimicrobials. Herein, we briefly summarize recent efforts and considerations that have been applied in the design ...

Domestic chicks (Gallus gallus domesticus) have been widely used as a model to study the motion cues that allow visually naïve organisms to detect animate agents shortly after hatching/birth. Our previous work has shown that chicks prefer to approach agents whose main body axis and motion direction are aligned (a feature typical of creatures whose motion is constrained by a bilaterally symmetric ...

Physical activity (PA) has been associated with reduced mortality among cancer survivors, but no study has focused on testicular cancer survivors (TCSs). We aimed to investigate the association of PA measured twice during survivorship with overall mortality in TCSs. TCSs treated during 1980 to 1994 participated in a nationwide longitudinal survey between 1998 to 2002 (S1: n = 1392) and 2007 to 2009 ...