Det helsevitenskapelige fakultet: Recent submissions
Now showing items 1001-1020 of 10398
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Entangling Reciprocity With the Relational in Narrative Inquiry
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-06-05)In this article, we develop, through drawing forward fragments of our experiences, a concept of reciprocity as always situated within the relational ontology of narrative inquiry. Reciprocity is most commonly understood within a transactional sense, an exchange of goods. We show important aspects of reciprocity in narrative inquiry, including the importance of intentionally creating and responding ... -
Regulation of Transcriptional Activity of Merkel Cell Polyomavirus Large T-Antigen by PKA-Mediated Phosphorylation
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-01-03)Merkel cell polyomavirus (MCPyV) is the major cause of Merkel cell carcinoma (MCC), an aggressive skin cancer. MCPyV large T-antigen (LTag) and small T-antigen (sTag) are the main oncoproteins involved in MCPyV-induced MCC. A hallmark of MCPyV-positive MCC cells is the expression of a C-terminal truncated LTag. Protein kinase A (PKA) plays a fundamental role in a variety of biological processes, ... -
Embedding Play to Enrich Physical Therapy
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-05-24)Play is an active process by which an individual is intrinsically motivated to explore the self, the environment, and/or interactions with another person. For infants and toddlers, engaging in play is essential to support development across multiple domains. Infants and toddlers with or at risk of motor delays may demonstrate differences in play or challenges with engaging in play activities compared ... -
Configuring Secretarial Workflows in the Epic EHR Suite
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023)The primary goal of large-scale electronic health record (EHR) suites is to meet the needs of a broad range of users in healthcare institutions. EHR suites are extensively configurable, which makes it possible to tailor them to diverse professional practices and users. However, while users such as physicians and nurses may have clearly defined responsibilities, clerical personnel (i.e. secretaries) ... -
Cancer drugs as drivers of antibiotic resistance
(Doctoral thesis; Doktorgradsavhandling, 2023-09-15)Antibiotics are the cornerstone for modern medicine, and their introduction into clinical use has made common medical procedures such as surgeries and cancer chemotherapy possible. The consequences of antimicrobial resistance (AMR), if it continues to rise on a global scale at its current speed, are expected to be staggering. It is well-known that antibiotics drive the evolution and spread of AMR, ... -
The transition to motherhood: Maternal well-being and mother-child bonding until four months postpartum. The role of mothers’ early maladaptive schemas, attachment style and the Newborn Behavioral Observation
(Doctoral thesis; Doktorgradsavhandling, 2023-09-21)In this thesis, it was investigated whether mothers` EMSs would predict maternal-fetal bonding quality during pregnancy (paper 1), whether attachment style would be associated with mother-infant bonding quality after birth (paper 2), and if these relations were mediated by symptoms of depression (paper 1) and parenting stress (paper 2). EMSs and anxious and avoidant attachment styles may be thought ... -
Supportive care for cancer-related symptoms in pediatric oncology: a qualitative study among healthcare providers
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-04-03)Background The aim of this study is to gain insight into the clinical experiences and perceptions that pediatric oncology experts, conventional healthcare providers, and complementary and alternative medicine (CAM) providers in Norway, Canada, Germany, the Netherlands, and the United States have with the use of supportive care, including CAM among children and adolescents with cancer.<p> <p>Methods ... -
Labour market status and mortality risk: the Finnmark cohort study 1987–2017
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-05-19)Aims: The aim of this study was to investigate the age-varying mortality risk associated with different labour market status categories.<p> <p>Methods: Data from a population-based survey carried out among adults aged 30–62 years in Finnmark in 1987/1988 were linked to the Norwegian Cause of Death Registry to identify all deaths occurring by December 2017. We used flexible parametric survival ... -
Measuring cortisol concentration in hair month-by-month two years retrospectively
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-01-30)Previous studies of cortisol concentrations in hair have concluded that it is not possible to measure more than 6 months retrospectively. This study shows for the first time that it is possible to analyze hair cortisol concentrations month-by-month for a retrospective period of 24 months. In addition, we have determined whether cortisol concentration decreases with time. The study population was ... -
Cause for Concern? The value of practical knowledge in professional education
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-06-22)The aim of this paper is to explore how practical knowledge can enhance higher education and Bildung for the human service professions. The paper sheds light on how governance reforms such as New Public Management have influenced higher education, where we argue that scientific rationality has weakened the professional’s autonomy and responsibility. The paper is based on the three authors’ experiences ... -
Cause for concern? The value of practical knowledge in professional education
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-06-22)The aim of this paper is to explore how practical knowledge can enhance higher education and Bildung for the human service professions. The paper sheds light on how governance reforms such as New Public Management have influenced higher education, where we argue that scientific rationality has weakened the professional’s autonomy and responsibility. The paper is based on the three authors’ experiences ... -
Results after surgical treatment of rectal cancer in Norway
(Doctoral thesis; Doktorgradsavhandling, 2023-09-15)Colorectal cancer is the third most common cancer worldwide, and rectal carcinoma represents about 25% of the cases. Surgical removal of the tumor is the standard curative treatment, and during the last decades the survival rates have improved through both better surgical methods and the introduction of radiochemotherapy. There is, however, still an ongoing debate on which treatment offers the best ... -
α,α-disubstituted β-amino amides eliminate Staphylococcus aureus biofilms by membrane disruption and biomass removal
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-08-25)Bacterial biofilms account for up to 80% of all infections and complicate successful therapies due to their intrinsic tolerance to antibiotics. Biofilms also cause serious problems in the industrial sectors, for instance due to the deterioration of metals or microbial contamination of products. Efforts are put in finding novel strategies in both avoiding and fighting biofilms. Biofilm control is ... -
Clinical associations for traditional and complementary medicine use among Norwegian cancer survivors in the seventh survey of the Tromsø study: a cross-sectional study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-03-04)Background Cancer survivors are a diverse group with varying needs that are patient-, disease-, and/or treatmentspecific. Cancer survivors have reported supplementing conventional anti-cancer treatment with Traditional and Complementary Medicine (T&CM). Although female cancer survivors are reported to have more severe anticancer adverse effects, little is known about the association between ... -
Human performance and medical treatment during cold weather operations - synthesis of a symposium
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-08-18)In October 2022, the Human Factors and Medicine (HFM) panel of the NATO Science and Technology Organization convened a review of progress in military biomedical research for cold weather operations. This paper represents a summary of the research presentations and future directions. The importance of realistic training was an overarching theme. Many reported studies took advantage of cold weather ... -
Smart delivery systems for microbial biofilm therapy: Dissecting design, drug release and toxicological features
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-01-18)Bacterial biofilms are highly protected surface attached communities of bacteria that typically cause chronic infections. To address their recalcitrance to antibiotics and minimise side effects of current therapies, smart drug carriers are being explored as promising platforms for antimicrobials. Herein, we briefly summarize recent efforts and considerations that have been applied in the design ... -
Dual-Energy X-Ray Absorptiometry Derived Adiposity Measures and Pre-Frailty/Frailty among Norwegian Adults: The Tromsø Study 2007–2015
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-05-25)OBJECTIVES: Aging is associated with changes in body composition. Excess adiposity among older adults has been linked with metabolic syndromes and aggravated age-associated decline in physical functioning. Few longitudinal studies have explored the association between dual-energy X-ray absorptiometry (DXA)-derived total as well as central adiposity measures and frailty. We examined the association ... -
Naïve chicks do not prefer objects with stable body orientation, though they may prefer behavioural variability
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-03-18)Domestic chicks (Gallus gallus domesticus) have been widely used as a model to study the motion cues that allow visually naïve organisms to detect animate agents shortly after hatching/birth. Our previous work has shown that chicks prefer to approach agents whose main body axis and motion direction are aligned (a feature typical of creatures whose motion is constrained by a bilaterally symmetric ... -
Trends in prevalence, treatment and control of hypertension in 38,825 adults over 36 years in Tromsø prospective study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-05-25)Aims/Background: Serial blood pressure surveys in cohort studies can inform public health policies to control blood pressure for prevention of cardiovascular diseases.<p> <p>Methods: Mean levels of systolic blood pressure (SBP) were collected in six sequential surveys, involving 38,825 individuals aged 30–79 years (51% female), between 1979 and 2015 in the Tromsø Study in Norway. Mean levels of ... -
Association of physical activity with overall mortality among long-term testicular cancer survivors: A longitudinal study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-06-19)Physical activity (PA) has been associated with reduced mortality among cancer survivors, but no study has focused on testicular cancer survivors (TCSs). We aimed to investigate the association of PA measured twice during survivorship with overall mortality in TCSs. TCSs treated during 1980 to 1994 participated in a nationwide longitudinal survey between 1998 to 2002 (S1: n = 1392) and 2007 to 2009 ...