Det helsevitenskapelige fakultet: Recent submissions
Now showing items 1061-1080 of 10404
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Mortality after hospital admission for trauma in Norway: A retrospective observational national cohort study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-05-28)Background - National quality data for trauma care in Norway have not previously been reported. We have therefore assessed crude and risk-adjusted 30-day mortality in trauma cases after primary hospital admission on national and regional levels for 36 acute care hospitals and four regional trauma centres.<p> <p>Methods - All patients in the Norwegian Trauma Registry in 2015–2018 were included. ... -
Opioid prescriptions among Sami and non-Sami with chronic pain: The SAMINOR 2 Questionnaire Survey and the Norwegian Prescription Database
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-07-28)This study is the first to investigate the prevalence of filled opioid prescriptions among indigenous Sami people with self-reported chronic musculoskeletal pain (CMSP) and compare it with that of non-Sami living in the same area. Baseline data from the SAMINOR 2 Questionnaire Survey (2012) was linked prospectively to the Norwegian Prescription Database. Information on filled opioid prescriptions ... -
A Qualitative Study Among Healthcare Providers on Risks Associated With the Use of Supportive Care for Cancer Treatment-Related Symptoms in Children and Adolescents
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-08-18)Introduction: Although more than 300 000 children and adolescents worldwide are diagnosed with cancer yearly, little research has been conducted investigating how healthcare providers consider risk and patient safety connected with supportive care (including complementary and alternative medicine [CAM]) in this age group. This study aimed to explore how different healthcare providers perceive and ... -
A systematic synthesis of qualitative studies on parents’ experiences of participating in early intervention programs with their infant born preterm
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-07-13)Early intervention programs involving both the parent and the infant born preterm have demonstrated positive effects on developmental outcomes for the children. However, studies have also shown that parental engagement and adherence when implementing intervention programs can be challenging. The aim of this review was to provide a comprehensive description and new insights into key messages gleaned ... -
Exploring the potential of a standardized test in physiotherapy: making emotion, embodiment, and therapeutic alliance count for women with chronic pelvic pain
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-08-03)Introduction: There has been an increased use of standardized measurements in health care meant to provide objective information to enhance the quality and effectivity of care. Patient performance tests are based on standardized predefined criteria with a limited focus. When facing multifaceted health conditions, information expanding the predefined criteria in a standardized test may be required ... -
Respiratory challenges and ventilatory management in different types of acute brain-injured patients
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-06-23)Acute brain injury (ABI) covers various clinical entities that may require invasive mechanical ventilation (MV) in the intensive care unit (ICU). The goal of MV, which is to protect the lung and the brain from further injury, may be difficult to achieve in the most severe forms of lung or brain injury. This narrative review aims to address the respiratory issues and ventilator management, specific ... -
Chronic pain concepts of pediatricians: a qualitative survey
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-01)Introduction: Chronic pain is a prevalent, yet underrecognized, condition in children and adolescents. A biopsychosocial framework has been widely adopted over the past decades and resulted in a new pain classification in the International Classification of Diseases, 11th revision (ICD-11). Nevertheless, little is known about pediatricians' pain concepts.<p> <p>Objectives: We explored pain ... -
“The effect of 48-weeks azithromycin therapy on levels of soluble biomarkers associated with HIV-associated chronic lung disease”
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-01-20)Objectives - HIV-associated immune activation contributes to chronic lung disease (CLD) in children and adolescents living with HIV. Azithromycin has immunomodulatory and anti-microbial properties that may be useful for treating HIV-associated CLD (HCLD). This study describes the effect of azithromycin on expression of plasma soluble biomarkers in children and adolescents with HCLD.<p> <p>Methods ... -
High-throughput screen in vitro identifies dasatinib as a candidate for combinatorial treatment with HER2-targeting drugs in breast cancer
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-01-27)Human epidermal growth factor receptor 2-positive (HER2+) breast cancer is an aggressive subtype of this disease. Targeted treatment has improved outcome, but there is still a need for new therapeutic strategies as some patients respond poorly to treatment. Our aim was to identify compounds that substantially affect viability in HER2+ breast cancer cells in response to combinatorial treatment. We ... -
Salary and power: How occupational status affects children's occupational aspirations
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-03-17)In many countries, labor markets are still highly gender segregated, with very few men working in communal occupations such as nursing. Because occupational aspirations start to develop during early childhood, it seems crucial to foster our understanding of which factors affect occupational aspirations during this period. Earlier correlational research showed that the status of occupations seems to ... -
Time trends in body height according to educational level. A descriptive study from the Tromsø Study 1979-2016
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-01-25)Objectives<p> <p>The objective of our study was to describe time trends in body height according to attained educational level in women and men in Norway. <p>Methods <p>We used previously collected data from six repeated cross-sectional studies in the population based Tromsø Study 1979–2016. Measured body height in cm and self-reported educational level were the primary outcome measures. We ... -
The challenge of dealing with non-AIDS comorbidities for people living with HIV: Perspectives and experiences of patients and healthcare providers
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-03-13)As the cohort of People Living with HIV (PLHIV) ages, so does the spectrum and burden of non-AIDS define HIV-associated conditions (NARC). PLHIV are likely to need different and increased healthcare services. It requires health systems to adapt to this disease trend and conform to a chronic care model, which respects the distinct needs of the ageing population. In this article, we explore the ... -
Assessing the effectiveness of if-then plans to facilitate increased fruit and vegetable intake in adults
(Mastergradsoppgave; Master thesis, 2023-05-15)Non-communicable diseases (NCDs) are prevalent, causing high rates of morbidity and mortality. A diet rich in fruit and vegetables are important in the prevention and management of NCDs. If-then plans is a planning strategy that could facilitate eating behaviour change by creating a mental link between a cue and a response in an “If…, then…”-structure. The aim was to investigate the effectiveness ... -
High plasma levels of C1-inhibitor are associated with lower risk of future venous thromboembolism
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-03-31)Background - C1-inhibitor (C1INH) is a broad-acting serine protease inhibitor with anticoagulant activity. The impact of C1INH plasma levels within the normal physiological range on risk of venous thromboembolism (VTE) is unknown. We assessed the association of plasma C1INH levels and VTE risk and evaluated the impact of C1INH on thrombin and plasmin generation in ex vivo assays.<p> <p>Methods - ... -
Plasma-Metanephrines in Patients with Autoimmune Addison’s Disease with and without Residual Adrenocortical Function
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-05-22)Purpose: Residual adrenocortical function, RAF, has recently been demonstrated in one-third of patients with autoimmune Addison’s disease (AAD). Here, we set out to explore any influence of RAF on the levels of plasma metanephrines and any changes following stimulation with cosyntropin. Methods: We included 50 patients with verified RAF and 20 patients without RAF who served as controls upon cosyntropin ... -
Food processing and cancer risk in Europe: results from the prospective EPIC cohort study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-03-06)Background - Food processing has been hypothesised to play a role in cancer development; however, data from large-scale epidemiological studies are scarce. This study investigated the association between dietary intake according to amount of food processing and risk of cancer at 25 anatomical sites using data from the European Prospective Investigation into Cancer and Nutrition (EPIC) study.<p> ... -
Improvement of personality functioning among people treated within personality disorder mental health services. A longitudinal, observational study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-05-09)Objective: Evidence-based personality disorder (PD) treatments are dominated by interventions targeting Borderline PD, although clinical populations characteristically include different PD features and severity. Personality functioning is a new concept intended to capture common features across PDs. This study aimed to investigate longitudinal improvement of personality functioning in a clinical ... -
Endogenous IL-1 receptor antagonist restricts healthy and malignant myeloproliferation
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-01-03)Here we explored the role of interleukin-1β (IL-1β) repressor cytokine, IL-1 receptor antagonist (IL-1rn), in both healthy and abnormal hematopoiesis. Low IL-1RN is frequent in acute myeloid leukemia (AML) patients and represents a prognostic marker of reduced survival. Treatments with IL-1RN and the IL-1β monoclonal antibody canakinumab reduce the expansion of leukemic cells, including CD34+ ... -
The association between body fatness and mortality among breast cancer survivors: results from a prospective cohort study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-03-29)Evidence linking body fatness to breast cancer (BC) prognosis is limited. While it seems that excess adiposity is associated with poorer BC survival, there is uncertainty over whether weight changes reduce mortality. This study aimed to assess the association between body fatness and weight changes pre- and postdiagnosis and overall mortality and BC-specific mortality among BC survivors. Our study ... -
Machine learning-based immune phenotypes correlate with STK11/KEAP1 co-mutations and prognosis in resectable NSCLC: a sub-study of the TNM-I trial
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-04-24)Background - We aim to implement an immune cell score model in routine clinical practice for resected non-small-cell lung cancer (NSCLC) patients (NCT03299478). Molecular and genomic features associated with immune phenotypes in NSCLC have not been explored in detail.<p> <p>Patients and methods - We developed a machine learning (ML)-based model to classify tumors into one of three categories: ...