Det helsevitenskapelige fakultet: Recent submissions
Now showing items 1141-1160 of 10404
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Parents’ perspectives on the role of kin in child-rearing: a qualitative study on Greenland’s universal parenting programme MANU
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-06-21)Nurturing care and protection from parents and community in the early years of life are fundamental for a child’s development. The article aims to explore what relations parents see as meaningful in their child’s upbringing and how these are shaped, and how these perspectives are reflected in MANU. MANU is a universal parenting programme in Greenland. Ten of 40 interviews with parents were selected ... -
Low-dose aspirin and risk of breast cancer: a Norwegian population-based cohort study of one million women
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-03-06)Several studies evaluated the association between aspirin use and risk of breast cancer (BC), with inconsistent results. We identifed women aged≥50 years residing in Norway between 2004 and 2018, and linked data from nationwide registries; including the Cancer Registry of Norway, the Norwegian Prescription Database, and national health surveys. We used Cox regression models to estimate the ... -
Legacy perfluoroalkyl acids and their oxidizable precursors in plasma samples of Norwegian women
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-06-12)Humans are exposed to perfluoroalkyl acids (PFAA) mainly through direct pathways, such as diet and drinking water, but indirect exposure also occurs when PFAA precursors break down to form legacy PFAA. Exposure to PFAA precursors raises particular concern, as neither the exposure nor the precursors themselves have been well described. In the present study, we aimed to assess the indirect contribution ... -
Palliative Radiotherapy for Non-metastatic Non-small-cell Lung Cancer: Impact of Blood Test Results on Survival
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-03)Background/Aim: Non-small-cell lung cancer (NSCLC) not amenable to curative treatment can be managed with palliative thoracic radiation or chemoradiation, however, with variable success. This study evaluated the prognostic impact of the LabBM score [serum lactate dehydrogenase (LDH), C-reactive protein, albumin, hemoglobin, platelets] in 56 patients who were scheduled to receive at least 10 ... -
Facilitating a safe and caring atmosphere in everyday life in forensic mental health wards - a qualitative study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-05-08)Purpose: To explore healthcare professionals’ experiences with facilitating a safe and caring atmosphere in patients’ everyday lives in forensic mental health wards.<p> <p>Methods: This qualitative study employed interviews with 16 healthcare professionals working shifts in two forensic mental healthcare wards in Norway. Data were analysed using phenomenological hermeneutic analysis. <p>Results: ... -
Rapid cross-border emergence of NDM-5-producing Escherichia coli in the European Union/European Economic Area, 2012 to June 2022
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-05-11)Whole genome sequencing data of 874 Escherichia coli isolates carrying blaNDM-5 from 13 European Union/ European Economic Area countries between 2012 and June 2022 showed the predominance of sequence types ST167, ST405, ST410, ST361 and ST648, and an increasing frequency of detection. Nearly a third (30.6%) of these isolates were associated with infections and more than half (58.2%) were ... -
Developing professional competence in an unfamiliar setting: Practice learning in Zambia
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-05-29)Background: Higher education needs to provide students with competencies to meet the health and social needs of a society characterised by increased globalisation and diversity. Occupational therapy students from Norway expressed that learning experiences outside their comfort zone within Zambian placements, have had a profound impact on their professional competence.<p> <p>Aims and objectives: ... -
The level of health anxiety before and during the COVID-19 pandemic
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-05-24)Background<p> <p>Concerns about disease and an increase in health anxiety levels are expected consequences of the COVID-19 pandemic. However, there have been few longitudinal studies of health anxiety in the general population during this time period. The aim of this study was to examine health anxiety levels before and during the COVID-19 pandemic in an adult, working population in Norway. <p>Material ... -
Cancer associated fibroblasts and their regulatory functions in the context of radiotherapy
(Doctoral thesis; Doktorgradsavhandling, 2023-08-25)<p>Tumours are highly complex tissues comprised of both malignant tumour cells and non-malignant healthy cells. Cells and tissues surrounding solid tumours make out the stroma, which provide physical support to the growing tumour structures, in addition to provide nutrients and facilitate waste removal. In the last four decades, it has become increasingly evident that stromal cells play important ... -
Evolutionary and functional history of the Escherichia coli K1 capsule
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-06-15)Escherichia coli is a leading cause of invasive bacterial infections in humans. Capsule polysaccharide has an important role in bacterial pathogenesis, and the K1 capsule has been firmly established as one of the most potent capsule types in E. coli through its association with severe infections. However, little is known about its distribution, evolution and functions across the E. coli phylogeny, ... -
Associations between dietary inflammatory scores and biomarkers of inflammation in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-05-17)Background - Since the first version of the dietary inflammatory index (DII®) developed in the past decade, several other versions have been developed. However, to date no study has attempted to compare these versions with respect to their associations with biomarkers of inflammation.<p> <p>Objective - We aimed to investigate the relationship between four dietary inflammatory scores [DII, two ... -
The impact of coding germline variants on contralateral breast cancer risk and survival
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-02-23)Evidence linking coding germline variants in breast cancer (BC)-susceptibility genes other than BRCA1, BRCA2, and CHEK2 with contralateral breast cancer (CBC) risk and breast cancer-specific survival (BCSS) is scarce. The aim of this study was to assess the association of protein-truncating variants (PTVs) and rare missense variants (MSVs) in nine known (ATM, BARD1, BRCA1, BRCA2, CHEK2, PALB2, RAD51C, ... -
Prediction of underlying atrial fibrillation in patients with a cryptogenic stroke: results from the NOR-FIB Study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-05-10)Background - Atrial fibrillation (AF) detection and treatment are key elements to reduce recurrence risk in cryptogenic stroke (CS) with underlying arrhythmia. The purpose of the present study was to assess the predictors of AF in CS and the utility of existing AF-predicting scores in The Nordic Atrial Fibrillation and Stroke (NOR-FIB) Study.<p> <p>Method - The NOR-FIB study was an international ... -
Dietary fatty acids and endometrial cancer risk within the European Prospective Investigation into Cancer and Nutrition
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-02-16)Background - Diet may impact important risk factors for endometrial cancer such as obesity and inflammation. However, evidence on the role of specific dietary factors is limited. We investigated associations between dietary fatty acids and endometrial cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC).<p> <p>Methods - This analysis includes 1,886 incident ... -
Risk prediction of atrial fibrillation and its complications in the community using hs troponin I
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-01-05)Aims - Atrial fibrillation (AF) is becoming increasingly common. Traditional cardiovascular risk factors (CVRF) do not explain all AF cases. Blood-based biomarkers reflecting cardiac injury such as high-sensitivity troponin I (hsTnI) may help close this gap.<p> <p>Methods - We investigated the predictive ability of hsTnI for incident AF in 45,298 participants (median age 51.4 years, 45.0% men) ... -
Women’s experiences and views on early breastfeeding during the COVID-19 pandemic in Norway: quantitative and qualitative findings from the IMAgiNE EURO study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-03-10)Background Little is known about women’s experience of care and views on early breastfeeding during the COVID19 pandemic in Norway.<p> <p>Methods Women (n =2922) who gave birth in a facility in Norway between March 2020 and June 2021 were invited to answer an online questionnaire based on World Health Organization (WHO) Standard-based quality measures, exploring their experiences of care and views ... -
Dynamics of SARS-CoV-2 Spike-IgG throughout Three COVID-19 Vaccination Regimens: A 21-Month Longitudinal Study of 82 Norwegian Healthcare Workers
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-02-23)To facilitate interpretation of clinical SARS-CoV-2 anti-spike IgG analyses post-vaccination, 82 healthcare workers were followed through three vaccination-regimens: two regimens were comprised of two doses of BNT162b2 three or six weeks apart, followed by a dose of mRNA-vaccine, and in the other regimen, the first dose was replaced by ChAdOx1 nCov-19. After each dose, anti-spike IgG was compared ... -
Evidence synthesis of Chinese medicine for monkeypox: Suggestions from other contagious pox-like viral diseases
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-03-13)Background: Monkeypox, a zoonotic disease caused by an Orthopoxvirus, presents an etiology similar to smallpox in humans. Currently, there are no licensed treatments for human monkeypox, so clear and urgent research on its prophylaxis and treatment is needed.<p> <p>Objective: The purpose of this study was to explore the evidence of Chinese medicine for contagious pox-like viral diseases and provide ... -
Fra lokalt til nasjonalt utbrudd av Pseudomonas aeruginosa
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-05-29)Utbrudd som rammer flere sykehus, krever god koordinering. Folkehelseinstituttets rolle i dette arbeidet bør styrkes, og vi trenger bedre systemer for utbruddsovervåking, rask tilgang til genteknologiske verktøy samt metoder for mikrobiologiske undersøkelser av miljø og utstyr. -
Older patients' experiences of access to and use of e-consultations with the general practitioner in Norway: an interview study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-01-02)Objective: To explore older patients’ experiences with accessing and using e-consultations to send text-based clinical inquiries to the general practitioner (GP) online.<p> <p>Design: Qualitative study based on semi-structured interviews. Results were analysed through a six-phase thematic analysis and interpreted through Levesque’s framework of patient-centred access to health care. <p>Setting: ...