Det helsevitenskapelige fakultet: Recent submissions

Now showing items 1281-1300 of 10404

    • Molecular modeling of the monoamine transporters and their interactions with psychostimulants and other substances 

      Gashi, Ejona (Mastergradsoppgave; Master thesis, 2023-05-15)
      The monoamines (i.e., dopamine, serotonin, and norepinephrine) are vital to the ontogeny, function, and plasticity of the nervous system. These neurotransmitters affect each other and regulate, amongst others, motor function, cognitive state, motivation, and stress reactions. The neurotransmission is mainly terminated by reuptake in monoamine transporters (MATs), i.e., the dopamine-, serotonin-, and ...

    • Synthesis, bioactivity testing, and structure elucidation of antimicrobial peptide analogues derived from Synoicum Turgens 

      Kristensen, Johannes (Mastergradsoppgave; Master thesis, 2023-05-15)
      A method was developed for synthesizing and isolating two DRPs, with varying levels of success affected by difficulties in the purification process and human error. However, it has shed light on some of the difficulties that may occur and suggestions on how they could be improved. The method developed structure elucidation through sequential reduction and alkylation of the disulfide bridges proved ...

    • Mass Spectrometry Based Metabolomic and Lipidomic Analyses of Algal Biomass. 

      Antonsen, Magnus Andersland (Mastergradsoppgave; Master thesis, 2023-05-14)
      Background: In a project at UiT - the Arctic University of Norway, the lipid profile of the microalgal biomass from the specie Porosira glacialis is mapped using HRMS lipidomic analyses to evaluate the potential for the biomass to be used as fish feed. At the same time, it is desired to screen the same biomass for bioactivities using bioassays in combination with HRMS metabolomic analyses. ...

    • Isolation and characterization of secondary metabolites from Arctic, Marine Invertebrates 

      Nyborg, Amalie Rebekka (Mastergradsoppgave; Master thesis, 2022-05-11)
      The search for bioactive compounds, or genes in macro- and microorganisms from the sea, is termed marine bioprospecting. Marine bioprospecting aims to increase the utilization and value of marine biomasses and organisms with the purpose of developing commercial products. Because of the special condition of the sea, it is known that marine invertebrates have adapted chemical defense strategies to ...

    • Exploring the Relationship Between Feeling of Rightness and Recall: A Study Challenging Dual Process Theory 

      Tveit, Nora (Mastergradsoppgave; Master thesis, 2023-04-28)
      Tidlig forskning på bedømming- og beslutningstaking antyder at vi har to systemer som tas i bruk når vi tenker: et raskt, intuitivt system (system 1) og et langsommere, mer overveiende system (system 2), referert til som toprosessteorien. Gjennom resonneringsoppgaver har denne forskningen vist at system 2 produserer normativt korrekte svar, og system 1 produserer feilaktige intuitive svar, og at ...

    • Man Enough to Care: Masculinity Threat and Misfit of Men Studying Communal Occupations 

      Lund, Ingvild Marie Hansen (Mastergradsoppgave; Master thesis, 2023-04-28)
      Fra en ung alder har menn internalisert kjønnsstereotypier av hva det vil si å være en "ekte" mann. Maskulinitetstrussel er frykten en mann opplever når de internaliserte kjønnsstereotypene ikke opprettholdes, de føler at maskuliniteten deres blir truet. I denne studien tar vi sikte på å undersøke om det å fremheve viktigheten av omsorgstrekk for mannlige studenter – men ikke kvinnelige studenter – ...

    • Social Jetlag and its Relation to Procrastination: The Possible Moderating Role of Daytime Fatigue and Affect 

      Færevaag, Klaus Svartdal (Mastergradsoppgave; Master thesis, 2023-04-28)
      This study aimed to assess the relationship between Social Jetlag (SJL) and procrastination among university students. SJL may occur when our biological circadian sleep clock is delayed as compared to our social clock (e.g., getting up early for work), causing an accumulation of sleep debt during the week. This may predict several maladaptive behaviors for students, such as procrastination. ...

    • The Role of Need for Cognition in the Association Between Work Demands and Home Outcomes 

      Rødfjell, Lenita Benedicte (Master thesis; Mastergradsoppgave, 2023-04-28)
      Kjærlighetsrelasjoner er en viktig del av våres liv og forskning viser til at kontekstuelle utfordringer (f.eks., arbeidsmengde), kan negativt påvirke slike relasjoner–et eksempel på jobb–til–liv konflikt. Arbeidet man utfører blir stadig mer komplekst og ansatte må utføre oppgaver som er både ukjente og utfordrende. Selv om slik kvalitativ arbeidsmengde er utbredt blant ansatte, vet vi lite om ...

    • Enhancing Leadership effectiveness in Virtual Teams: The Moderating Role of Transformational Leadership on Exhaustion and Job Satisfaction 

      Moe, Thea Victoria (Master thesis; Mastergradsoppgave, 2023-04-28)
      Fremveksten av virtuelt arbeid og bruken av virtuelle teams i organisasjoner, ble intensivert av den nylige globale COVID-19-pandemien, og derved også behovet for å forstå hvordan en leders effektivitet kan bli påvirket i virtuelle arbeids kontekster. Denne studien undersøker den potensielt modererende rollen til transformasjonsledelse på forholdet mellom virtuelle teams og leder effektivitet, gjennom ...

    • The identification of cell type defining genes across human tissues and the functional study of the endothelial adhesion G protein-coupled receptor L4 

      Norreen-Thorsen, Marthe (Doctoral thesis; Doktorgradsavhandling, 2023-06-30)
      Cell type specific gene expression profiles underlie differences in cell morphology, behaviour, and specialized function. Single cell RNA sequencing can be used to measure gene expression in individual cells, but challenges remain including limited read-depth, artefactual changes due to dissociation from tissue, difficulties in the analysis of fragile or morphologically complex cell types, and bias ...

    • Synthesis and structure-activity relationship studies of marine-derived antimicrobial peptides and small cyclic peptidomimetics 

      Simonovic, Danijela (Doctoral thesis; Doktorgradsavhandling, 2023-06-26)
      Effective antimicrobial drugs are the very core of modern medicine enabling successful prevention and treatment of infectious diseases. However, systemic misuse and overuse of antibiotics in human medicine, as well as in animal husbandry have led to widespread antibiotic-resistance, rendering many of these drugs ineffective. Therefore, there is an urgent need for new treatment options to conventional ...

    • Within-patient and global evolutionary dynamics of Klebsiella pneumoniae ST17 

      Hetland, Marit; Hawkey, Jane; Bernhoff, Eva; Bakksjø, Ragna-Johanne; Kaspersen, Håkon; Rettedal, Siren; Sundsfjord, Arnfinn; Holt, Kathryn E.; Löhr, Iren Høyland (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-05-18)
      Klebsiella pneumoniae sequence type (ST) 17 is a global problem clone that causes multidrug-resistant (MDR) hospital infections worldwide. In 2008–2009, an outbreak of MDR ST17 occurred at a neonatal intensive care unit (NICU) in Stavanger, Norway. Fifty-seven children were colonized. We observed intestinal persistence of ST17 in all of the children for up to two years after hospital discharge. ...

    • Intended, Unintended, Unanticipated? Consequences of Social Distancing Measures for Nursing Home Residents During the Covid-19 Pandemic 

      Tingvold, Laila; Moholt, Jill-Marit; Førland, Oddvar; Jacobsen, Frode Fadnes; Tranvåg, Oscar (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-05-28)
      During the outbreak of the COVID-19 pandemic, Norwegian health authorities introduced social distancing measures in nursing homes. The aim was to protect vulnerable residents from contracting the potentially deadly infection. Drawing on individual interviews with nursing home managers and physicians, and focus groups with nursing staff, we explore and describe consequences the social distancing ...

    • Dokumentasjonspraksis og bruk av elektronisk tiltaksplan for døende pasienter i sykehjem – en mysteriefokusert studie 

      Brattgjerd, Marianne; Danielsen, Inger Jorun; Næss, Grethe Bøgh; Olsen, Rose Mari (Chapter; Bokkapittel, 2019-07-15)
      Liverpool Care Pathway (LCP) er en tiltaksplan og et dokumentasjonsverktøy som har til hensikt å kvalitetssikre omsorg ved livets slutt. I Norge er 329 sykehjem registrerte brukere av tiltaksplanen. Planen finnes i både papirbasert- og elektronisk format. Hensikten med denne studien var å utforske dokumentasjonspraksisen når elektronisk tiltaksplan brukes til døende pasienter i sykehjem. Studien ...

    • Assessing new prognostic biomarkers in resected colon cancer patients 

      Selven, Hallgeir (Doctoral thesis; Doktorgradsavhandling, 2023-06-22)
      Colon cancer is a common malignancy. We retrospectively established a biobank including 452 patients operated for colon cancer stage I-III in Northern Norway in the period 1998-2007. Tissue microarrays (TMAs) containing tumor tissue from these patients were constructed, and subsequently biomarker expression assessed by digital pathology. By using in situ hybridization, we assessed the expression of ...

    • Association between physical activity and carotid atherosclerosis 

      Hansen, Lisa Gullhav (Master thesis; Mastergradsoppgave, 2019-06-03)
      Background/aim: Physical activity reduces the risk of cardiovascular disease (CVD). Atherosclerosis is an important common underlying cause of CVD. It is not clear whether the beneficial effect of physical activity on CVD is mediated through effect on atherosclerosis, and previous studies have shown diverging results. The aim of this study was to investigate the association between level of physical ...

    • Innvirkning av syklisk-di-GMP signalisering på antimikrobiell resistens i Acinetobacter baumannii. Undersøkelser av relativ genekspresjon og fenotypiske effekter hos transposon insersjonsmutanter i putative c-di-GMP signaliseringsgener. 

      Phung, Minh Chau Nguyen (Mastergradsoppgave; Master thesis, 2020-06-03)
      Antimikrobiell resistens (AMR) utgjør en av de tre viktigste helseproblemene i verden i dag, og kan medføre alvorlige konsekvenser ifølge Verdens helseorganisasjon (WHO). Resistensutviklingen fører til terapisvikt mot infeksjonssykdommer som tidligere lot seg behandle av antimikrobielle midler og flere millioner menneskeliv kan gå tapt, hvis ikke tiltak iverksettes for å redusere forekomsten av AMR. ...

    • Ethnic identity and eating disorders in adolescence and mental health in young adulthood 

      Niia, Katarina Sofie Holmlund (Master thesis; Mastergradsoppgave, 2021-05-31)
      <p>Background: How the Sami ethnicity, ethnic factors and ethnic discrimination are related to mental health has been investigated previously. An interesting, and as far as I know until now unexplored topic of research is the relationship between adolescence eating disorders, ethnic factors, and mental health outcome in young adulthood. The aims of the study was to investigate the relationship between ...

    • Bakteriofagterapi – et bærekraftig alternativ eller supplement til antibiotika. En systematisk litteraturstudie på bruk av bakteriofagterapi mot behandlingsresistente infeksjoner forårsaket av Gram-negative bakterier 

      Sollid, Elin Helena (Master thesis; Mastergradsoppgave, 2021-05-31)
      <p>Bakgrunn: Overdreven bruk av antimikrobielle midler har ført til utbredt seleksjon og spredning av antimikrobiell resistens i klinisk viktige bakterier. Når tradisjonelle antimikrobielle midler svikter i infeksjonsbehandling, øker både morbiditet og mortalitet hos pasientene, og det finnes få behandlingsalternativ. Bakteriofagterapi har kommet i søkelyset som et mulig alternativ, eller supplement, ...

    • Kjønnsforskjeller i traumebehandling? En retrospektiv gjennomgang av data fra Nasjonalt traumeregister i Norge 

      Kröger, Mira-Maria (Master thesis; Mastergradsoppgave, 2021-05-31)
      <p>Bakgrunn: Utenlandske studier har vist at behandling av traumepasienter varierer mellom kjønn. Dette er ikke undersøkt i Norge. Vi ønsket å undersøke om menn og kvinner i Norge mottar samme prehospital behandling. <p>Metode: Data er innhentet fra Nasjonalt traumeregister fra tidsperioden 01.01.2015-31.12.2018. Vi inkluderte alle pasienter ≥ 18 år, som var i live når prehospital helsepersonell ...