SIRT1 (Sir2) is an NAD⁺-dependent deacetylase that plays critical roles in a broad range of biological events, including metabolism, the immune response and ageing^1,2,3,4,5. Although there is strong interest in stimulating SIRT1 catalytic activity, the homeostasis of SIRT1 at the protein level is poorly understood. Here we report that macroautophagy (hereafter referred to as ...

Aberrant belief updating due to misestimation of uncertainty and an increased perception of the world as volatile (i.e., unstable) has been found in autism and psychotic disorders. Pupil dilation tracks events that warrant belief updating, likely reflecting the adjustment of neural gain. However, whether subclinical autistic or psychotic symptoms affect this adjustment and how they relate to learning ...

Aberrant belief updating due to misestimation of uncertainty and an increased perception of the world as volatile (i.e., unstable) has been found in autism and psychotic disorders. Pupil dilation tracks events that warrant belief updating, likely refecting the adjustment of neural gain. However, whether subclinical autistic or psychotic symptoms afect this adjustment and how they relate to learning ...

Vi har utarbeidet en fullstendig metodevurdering av kirurgi med sutur sammenlignet med ikke-kirurgisk behandling ved degenerativ fulltykkelse rotatorcuff-ruptur. Vi inkluderte fem randomiserte og 18 ikke-randomiserte studier. Vi sammenstilte studiene i metaanalyser og vurderte tilliten til effektestimatene med GRADE-tilnærmingen. <p> <uli> <li>For pasienter med ruptur i én sene gir kirurgi liten ...

Spillbasert læring bruker prinsipper fra spill for å engasjere og motivere studenter i sin læring. I kombinasjon med innsikter om effektive læringsstrategier kan spillbaserte læringsressurser sikre både motivasjon til å lære og en effektiv læringsprosess. En forutsetning for å lykkes med introduksjon av ny teknologi generelt og spillbaserte læringsressurser spesifikt er at teknologien aksepteres av ...

Aberrant belief updating due to misestimation of uncertainty and an increased perception of the world as volatile (i.e., unstable) has been found in autism and psychotic disorders. Pupil dilation tracks events that warrant belief updating, likely refecting the adjustment of neural gain. However, whether subclinical autistic or psychotic symptoms afect this adjustment and how they relate to learning ...

In recent years, cases of vasskveite (water halibut) syndrome in halibut have been increasing. At the moment, there exists no way to screen for the syndrome immediately after capture, which is problematic for both exporters and purchasers. In this article, we compared good quality halibut and halibut exhibiting the syndrome using a variety of techniques. Hyperspectral imaging was used to quantify ...

Hensikt - Formålet med denne artikkelen er å gi en oversikt over bruk og utvikling av PETradiofarmaka i Norge.<p> <p>Kunnskapsgrunnlag/Metode - Artikkelen bygger på innrapporterte tall over antall administrasjoner av radiofarmaka fra helseforetakene til Direktoratet for strålevern og atomsikkerhet (DSA). Det ble benyttet ikke-systematisk litteratursøk i PubMed og Google Scholar frem til ...

The main objective of this study is to gain knowledge about interactional factors that support and obstruct mutual risk-assessments and shared decision-making (SDM) in clinical consultations. Through a narrative analysis of verbatim tran- scripts of 28 naturally occurring consultations performed in English National Health Service practices, we explore the ways in which patients and general practitioners ...

Abstract Rationale The number of torture survivors is on the rise, posing issues for their care in healthcare settings. Even healthcare experts with training in refugee care are unaware of the health difficulties faced by torture survivors. Any medical evaluation or treatment has the potential to re-traumatize torture survivors, thereby reactivating trauma symptoms without applicable guidelines ...