Det helsevitenskapelige fakultet: Recent submissions
Now showing items 1521-1540 of 10407
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Can Difficult Lectures be Interesting AND Pleasant? Hedonic and Eudaimonic Feelings as a Function of Perceived Difficulty
(Master thesis; Mastergradsoppgave, 2022-12-01)What is it that makes challenge and complexity so appealing to humans? Research derived from positive psychology have tried to answer this question, and in the process found evidence suggesting that people experience different feelings as the perception of difficulty rises. In this study, using Gudrun Eckblad’s scheme theory as premise, we predicted that reported feelings of pleasure would be most ... -
Visual problems are associated with long-term fatigue after stroke
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-01-30)Objective: Post-stroke fatigue may be associated with functioning even in patients with mild stroke. In order to guide rehabilitation, the aim of this study was to investigate the independent contribution of 12 function-related domains to severe long-term fatigue.<p> <p>Design: Observational follow-up study. Subjects: A total of 144 stroke survivors (mean age 67.3, standard deviation (SD) 10.9 ... -
The effect of machine learning tools for evidence synthesis on resource use and time-to-completion: protocol for a retrospective pilot study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-01-17)Background Machine learning (ML) tools exist that can reduce or replace human activities in repetitive or complex tasks. Yet, ML is underutilized within evidence synthesis, despite the steadily growing rate of primary study publication and the need to periodically update reviews to reflect new evidence. Underutilization may be partially explained by a paucity of evidence on how ML tools can reduce ... -
Changing patterns in treatment, remission status, and categories in a long-term Nordic cohort study of juvenile idiopathic arthritis
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-01-10)Objective - To explore sustainability of achieved remission off medication and defined International League of Associations for Rheumatology (ILAR) categories in juvenile idiopathic arthritis (JIA) and describe the trajectory of disease course over time by comparing treatment, disease activity, and ILAR categories from baseline, 8 years, and 18 years after disease onset.<p> <p>Methods - A total ... -
Body mass index, waist circumference and pre-frailty/frailty: the Tromsø study 1994−2016
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-01-23)Objective This study investigated the association between obesity, assessed using body mass index (BMI) and waist circumference (WC), and pre-frailty/frailty among older adults over 21 years of follow-up. <p>Design Prospective cohort study. <p>Setting Population-based study among communitydwelling adults in Tromsø municipality, Norway. <p>Participants 2340women and 2169 men aged ≥45 years ... -
Efficacy and safety of baricitinib in hospitalized adults with severe or critical COVID‑19 (Bari‑SolidAct): a randomised, double‑blind, placebo‑controlled phase 3 trial
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-01-10)Background Baricitinib has shown efcacy in hospitalized patients with COVID-19, but no placebo-controlled trials have focused specifcally on severe/critical COVID, including vaccinated participants.<p> <p>Methods Bari-SolidAct is a phase-3, multicentre, randomised, double-blind, placebo-controlled trial, enrolling participants from June 3, 2021 to March 7, 2022, stopped prematurely for external ... -
High Levels of Complement Activating Enzyme MASP-2 Are Associated With the Risk of Future Incident Venous Thromboembolism
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-07-21)Background: Experimental studies have shown that the complement activating enzyme MASP-2 (mannose-binding lectin associated serine protease 2) exhibits a thrombin-like activity and that inhibition of MASP-2 protects against thrombosis. In this study, we investigated whether plasma MASP-2 levels were associated with risk of future venous thromboembolism (VTE) and whether genetic variants linked to ... -
Feedback Effects on Mind Wandering: A Series of Online Experiments
(Mastergradsoppgave; Master thesis, 2022-05-01)Replicating in-lab experiments online can ensure scientific progress when physical contact is discouraged, like during the covid-19 pandemic. In this thesis, we replicated the results from Boayue et al. (2021) in-lab Mind Wandering (MW) experiment online. The task uses the Finger-Tapping Random Sequence Generation Task, a sustained attention task, equating MW with Task Unrelated Thoughts (TUTs). In ... -
Birthday Celebrations Social Impact. What Can We Lear From Children’s Experiences?
(Mastergradsoppgave; Master thesis, 2022-12-01)Children’s birthday celebrations are a social event including different social activities and birthday rituals. As previous research show rituals to enhance cohesion amongst its ritual participants, we assumed in-group and out-group memberships could be established at birthday celebrations between children in an already constituted group. With this study we aim to gain a better understanding of ... -
The ubiquitin E3 ligase TRIM27 emerges as a new player in mitophagy
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-01-05)Mitochondria are the center for energy production, cell fate determination and synthesis of essential biomolecules in cells. Hence, mitochondrial quality control mechanisms are essential for cellular health. Failure of these control mechanisms may lead to damaged mitochondria that represent a threat to cell survival. Mitophagy is a selective autophagy process that removes damaged mitochondria ... -
Obesity-related venous thromboembolism
(Doctoral thesis; Doktorgradsavhandling, 2023-02-22)Venous thromboembolism (VTE), a collective term for deep vein thrombosis (DVT) and pulmonary embolism (PE), is a common and multicausal disease. Obesity is a major and likely causal risk factor for VTE. However, to what extent obesity contributes to VTE risk in the general population and the mechanism of obesity-related VTE remain poorly understood. The overall aim of this thesis was (i) to ... -
Observer agreement of imaging measurements used for evaluation of dentofacial deformity in juvenile idiopathic arthritis
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-08-02)Objectives: To examine the precision of imaging measures commonly used to assess mandibular morphology in children and adolescents with juvenile idiopathic arthritis (JIA). Secondly, to compare cone-beam computed tomography (CBCT) and magnetic resonance imaging (MRI) in the measurement of condylar height.<p> <p>Methods: Those included were children diagnosed with JIA during 2015–18 who had had ... -
Inflammation and cognition in severe mental illness: patterns of covariation and subgroups
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-12-28)A potential relationship between dysregulation of immune/inflammatory pathways and cognitive impairment has been suggested in severe mental illnesses (SMI), such as schizophrenia (SZ) and bipolar (BD) spectrum disorders. However, multivariate relationships between peripheral inflammatory/immune-related markers and cognitive domains are unclear, and many studies do not account for inter-individual ... -
A Universal Mental Health–Promoting Mobile App for Adolescents: Protocol for a Cluster Randomized Controlled Trial
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-01-11)Background: In times of increasing mental health problems among young people, strengthening efforts to improve mental health through mental health promotion and prevention becomes increasingly important. Effective measures that support young people in coping with negative thoughts, feelings, and stress are essential, not just for the individual but also for society. Objective: The aim of this ... -
Bronkiolitt skal ikke behandles med glukokortikoider eller antibiotika
(Journal article; Tidsskriftartikkel; Peer reviewed, 2021-12-30)Vi er inne i en hektisk sesong med virale luftveisinfeksjoner. Respiratorisk syncytialvirus (RS-virus) er den hyppigste årsaken til bronkiolitt hos barn. Pediatriveilederen er tydelig på at perorale glukokortikoider ikke har noen plass i behandlingen av bronkiolitt og at det sjelden er behov for antibiotika. -
Predicting Commercial Pilot Training Performance: A Validation Study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-09-19)The main purpose of this study was to examine the predictive validity of the system used for ab initio selection of candidates to a bachelor program in aviation. The selection includes paper-and-pencil tests, computer-based tests, and an interview. A total of 188 candidates participated in the validation study. The total test score predicted the results of three exams in aviation theory (r = .27–.38) ... -
Cardiovascular disease: risk assessment, total risk, and primary prevention in the general population. Insights from the Tromsø Study
(Doctoral thesis; Doktorgradsavhandling, 2023-02-20)Cardiovascular disease (CVD) is a major cause of mortality and morbidity, calling for an active preventive approach. Elevated blood pressure and cholesterol, smoking, diabetes, unhealthy diet, inactivity, and obesity are key risk factors for CVD development. Several risk factors combined may put an individual at a high total CVD risk. To measure total CVD risk, we used the NORRISK 2 score that ... -
Novel approach to artefact detection and the definition of normal ranges of segmental strain and strain-rate values
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-12-13)Aims - Strain artefacts are known to hamper the correct interpretation of segmental strain and strain-rate (S/SR). Defining the normal ranges of myocardial segmental deformation is important in clinical studies and routine echocardiographic practice. In order to define artefact-free normal ranges for segmental longitudinal S/SR parameters, we investigated the extent to which different types of ... -
Gender Gap in Parental Leave Intentions: Evidence from 37 Countries
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-01-23)Despite global commitments and efforts, a gender-based division of paid and unpaid work persists. To identify how psychological factors, national policies, and the broader sociocultural context contribute to this inequality, we assessed parental-leave intentions in young adults (18–30 years old) planning to have children (N = 13,942; 8,880 identified as women; 5,062 identified as men) across 37 ... -
Samfunn og sykdom. Bokanmeldelse av "Medicinsk sociologi: sociale faktorers betydning for befolkningens helbred", redigert av Rikke Lund, Charlotte Juul Nilsson, Ulla Christensen og Lars Iversen.
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022)Denne reviderte artikkelsamlingen har som hovedtema sammenhengen mellom samfunn og sykdom, spesielt hvordan sosiale og samfunnsmessige forhold har betydning for folks helse, med utgangspunkt i «socialepidemiologiske metoder» (s. 14). Boken inneholder i alt 10 kapitler, samt innledning og stikkordsregister, og den er rikt illustrert med figurer og tabeller i fargetrykk. Forfatterne kommer fra ulike ...