Det helsevitenskapelige fakultet: Recent submissions
Now showing items 1781-1800 of 10407
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Tuning of Liver Sieve: The Interplay between Actin and Myosin Regulatory Light Chain Regulates Fenestration Size and Number in Murine Liver Sinusoidal Endothelial Cells
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-08-30)Liver sinusoidal endothelial cells (LSECs) facilitate the efficient transport of macromolecules and solutes between the blood and hepatocytes. The efficiency of this transport is realized via transcellular nanopores, called fenestrations. The mean fenestration size is 140 ± 20 nm, with the range from 50 nm to 350 nm being mostly below the limits of diffraction of visible light. The cellular ... -
Høyt nivå av tungmetaller i krabbe
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-09-01)Krabber er populær sjømat, men kan inneholde til dels store mengder miljøgifter. Innholdet er mange steder i Norge så høyt at inntak av brunmaten generelt bør frarådes. -
Laktat i fosterskalpblodprøve som markør for føtal hypoksi
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-07-11)Evidensgrunnlaget for å ta blodprøver fra fosterskalpen er svakt. Fører prøvene til færre intervensjoner eller bedre utfall for fosteret? -
Hvordan forbedre?
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-06-13)Hei, det er vanskelig ut fra innlegget å se hva som faktisk skal kunne bidra til en «bredere rekrutteringsbase» -
En mann i 40-årene med akutt forvirring
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-06-07)Rask og adekvat utredning av akutte nevropsykiatriske symptomer er avgjørende for effektiv behandling. Her beskriver vi en pasient med en karakteristisk, men relativt sjelden sykdom. -
Pre-diagnostic DNA methylation in blood leucocytes in cutaneous melanoma; a nested case–control study within the Norwegian Women and Cancer cohort
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-08-20)The prognosis of cutaneous melanoma depends on early detection, and good biomarkers for melanoma risk may provide a valuable tool to detect melanoma development at a pre-clinical stage. By studying the epigenetic profile in pre-diagnostic blood samples of melanoma cases and cancer free controls, we aimed to identify DNA methylation sites conferring melanoma risk. DNA methylation was measured at ... -
Protocol of a mixed-method randomised controlled pilot study evaluating a wilderness programme for adolescent and young adult cancer survivors: the WAYA study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-05-09)Introduction - The majority of childhood, adolescent and young adult (AYA) cancer survivors suffer from long-term and late effects such as fatigue, psychological distress or comorbid diseases. Effective health promotion strategies are needed to support the health of this vulnerable group. This protocol provides a methodological description of a study that aims to examine the feasibility and safety ... -
Public and outpatients’ awareness of calling emergency medical services immediately by acute stroke in an upper middle-income country: a cross-sectional questionnaire study in greater Gaborone, Botswana
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-09-14)Objectives - In this cross-sectional study from Botswana, we investigated awareness of calling emergency medical services (EMS) and seeking immediate medical assistance by acute stroke among stroke risk outpatients and public.<p> <p>Method - Closed-ended questionnaires on awareness of calling EMS and seeking immediate medical assistance by acute stroke, were administered by research assistants ... -
Adherence and persistence to pharmacotherapy in patients with heart failure: a nationwide cohort study, 2014–2020
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-10-20)Aims - We aimed to study initiation, adherence, and long-term persistence to beta-blockers (BB), renin–angiotensin system inhibitors (RASi), and mineralocorticoid receptor antagonists (MRA) in a nationwide cohort of patients with heart failure (HF).<p> <p>Methods - Patients aged 18–80 years in Norway with a first diagnosis of HF from 2014 until 2020 that survived ≥30 days were identified from the ... -
Transitioning patients with juvenile idiopathic arthritis to adult care: the Nordic experience
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-10-01)Background: With juvenile idiopathic arthritis (JIA), there are several protocols and practices used worldwide for the transition from paediatric to adult care. In this study, we examined the transferral rates and disease activity after transition, as well as the disease- and health-related outcomes. We also introduce the transition practices employed in the Nordic countries.<p> <p>Methods: The ... -
Early surfactant and non-invasive ventilation versus intubation and surfactant: a propensity score-matched national study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-07-27)<p><b> Objective</b> To compare outcome after less invasive surfactant administration (LISA) and primary endotracheal intubation (non-LISA) in infants born before gestational age (GA) 28 weeks. <p><b> Setting</b> All neonatal intensive care units (NICUs) in Norway during 2012–2018. <p><b> Methods</b> Defined population-based data were prospectively entered into a national registry. We ... -
Active commuting and work ability: A cross-sectional study of chicken meat industry workers in Thailand
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-08-11)There is ample evidence regarding positive health effects of cycling or walking to work (active commuting [AC]). However, little is known about the effects of AC on work ability. Therefore, we examined 422 Thai chicken meat industry workers who assessed their current work ability (CWA) compared to their lifetime best by assigning scores ranging from 0 to 10. The CWA was compared between active ... -
Using storytelling in undergraduate dental education: Students' experiences of emotional competence training
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-11-03)Aim: The aim of the study was to explore the use of storytelling as a teaching method for emotional competence interventions within undergraduate dental curriculum (dental and dental hygiene students).<p> <p>Materials and Methods: Students participated in five sessions related to emotional competence: one theoretical and four practical. During the latter, divided in small groups, students told ... -
Lokalbehandling av utbrudd ved Hidrosadenitt
(Master thesis; Mastergradsoppgave, 2020-11-13)<p>Bakgrunn: Hidrosadenitt (HS) er en kronisk inflammatorisk hudsykdom som kjennetegnes av et svingende forløp med hyppige residiv av smertefulle lesjoner. Tilstanden er en klinisk utfordring, spesielt da informasjon om best tilgjengelig behandling av disse utbruddene er vanskelig tilgjengelig for klinikere. Formålet med oppgaven er å undersøke dokumentasjonen bak disse behandlingsformene, også med ... -
Crosstalk between AML and stromal cells triggers acetate secretion through the metabolic rewiring of stromal cells
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-09-02)Acute myeloid leukaemia (AML) cells interact and modulate components of their surrounding microenvironment into their own benefit. Stromal cells have been shown to support AML survival and progression through various mechanisms. Nonetheless, whether AML cells could establish beneficial metabolic interactions with stromal cells is underexplored. By using a combination of human AML cell lines and AML ... -
ALYREF, a novel factor involved in breast carcinogenesis, acts through transcriptional and post-transcriptional mechanisms selectively regulating the short NEAT1 isoform
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-07-01)The RNA-binding protein ALYREF (THOC4) is involved in transcriptional regulation and nuclear mRNA export, though its role and molecular mode of action in breast carcinogenesis are completely unknown. Here, we identifed high ALYREF expression as a factor for poor survival in breast cancer patients. ALYREF signifcantly infuenced cellular growth, apoptosis and mitochondrial energy metabolism in ... -
Total Oxidizable Precursors Assay for PFAS in Human Serum
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-11-23)Per- and polyfluoroalkyl substances (PFAS) are a class of chemicals including over 4700 substances. As a limited number of PFAS is routinely analyzed in human serum, complementary analytical methods are required to characterize the overlooked fraction. A promising tool is the total oxidizable precursors (TOP) assay to look for precursors by oxidation to perfluoroalkyl acids (PFAA). The TOP assay was ... -
Physical activity attenuates but does not eliminate coronary heart disease risk amongst adults with risk factors: EPIC-CVD case-cohort study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-04-11) -
Two-year motor outcomes associated with the dose of NICU based physical therapy: The Noppi RCT
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-09-25)Background - Interventions involving both the parent and the preterm infant have demonstrated lasting effects on cognitive outcomes, but motor effects are less salient. It remains unclear when to commence early intervention and if dosages have impact on motor outcomes.<p> <p>Aims - To examine the effect on motor performance at 24-months corrected age following a parent-administered intervention ... -
A four-month home-based tDCS study on patients with Alzheimer’s disease
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-07-19)In the present open-label study, our first aim was to study the tolerability and feasibility of long-term treatment with transcranial direct current stimulation (tDCS) and the second aim was to measure whether the treatment led to cognitive improvement. Participants with AD used a tDCS home-treatment kit inducing a low current (2 mA) via two scalp electrodes 30 minutes daily for 4 months. A total ...