Purpose To examine whether the detrimental smoking-related association with pancreatic cancer (PC) is the same for women as for men.<p> <p>Methods We analyzed data from 192,035 participants aged 45–75 years, enrolled in the Multiethnic Cohort study (MEC) in 1993–1996. We identifed PC cases via linkage to the Hawaii and California Surveillance, Epidemiology, and End Results Program cancer registries ...

Epithelial alarmins are gaining interest as therapeutic targets for chronic infammation. The nuclear alarmin interleukin-33 (IL-33) is upregulated in the colonic mucosa of acute ulcerative colitis (UC) and may represent an early instigator of the infammatory cascade. However, it is not clear what signals drive the expression of IL-33 in the colonic mucosa, nor is the exact role of IL-33 elucidated. We ...

Barns rett til å høres blir stadig formelt styrket. Meklere i familievernet som skal iverksette denne retten i forbindelse med foreldres samlivsbrudd, har et betydelig rom for skjønnsutøvelse. Det foreligger begrenset kunnskap om hvordan og hvorfor praksis varierer. I denne artikkelen analyserer vi 20 mekleres diskusjoner rundt barns rett til å høres i forbindelse med foreldremekling. Vi anlegger ...

<p><i>Background:</i> Critical illness not only disrupts the patient’s life, but also the lives of close family members. The care provided by ICU nurses and physicians can reduce the family members’ burden and improve the patient's outcome. Previous research shows that although ICU families generally report high satisfaction, there are several barriers to family care and areas for improvement. Family ...

This work is focused on understanding the treatment efficacy of patients with ulcerative colitis (UC) using a network-based approach. UC is one of two forms of inflammatory bowel disease (IBD) along with Crohn’s disease. UC is a debilitating condition characterized by chronic inflammation and ulceration of the colon and rectum. UC symptoms occur gradually rather than abruptly, and the degree of ...

Han fikk avslag fra Teaterhøgskolen begge gangene han søkte. I dag bruker fastlege Morten Munkvik sine formidlingsevner til å lage bøker, tegneserier, sanger og radio om allmennmedisin til tusenvis av lyttere hver uke.

Identification of individuals with ischemic stroke at particularly high risk of venous thromboembolism (VTE) is crucial for targeted thromboprophylaxis. To guide clinical decision-making and development of risk prediction models, increased knowledge on risk factors and biomarkers is needed. Therefore, we set out to identify risk factors and predictors for VTE in people with ischemic stroke by ...

We have a desire to discover and create order, and our constitution, including our rational faculties, indicates that we are predisposed for such productivity. This affinity for order and the establishment of order is fundamental to humans and naturally also leaves its mark on the medical discipline. When this profession is made subject to criticism, frequently in terms of well-used reproofs such ...

Small heat shock proteins (sHSPs) have been demonstrated to interact with lipids and modulate the physical state of membranes across species. Through these interactions, sHSPs contribute to the maintenance of membrane integrity. HSPB1 is a major sHSP in mammals, but its lipid interaction profile has so far been unexplored. In this study, we characterized the interaction between HSPB1 and phospholipids. ...

Men often experience depressive symptoms during the transition to parenthood, but there is a lack of synthesized knowledge of instruments used to identify such symptoms. The aim of this scoping review was to identify instruments used to measure symptoms of depressive symptoms among fathers in pregnancy and the postpartum period, and to describe the instruments’ characteristics and measurement ...