Det helsevitenskapelige fakultet: Recent submissions
Now showing items 1981-2000 of 10407
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Sex-specific factors associated with lifetime suicide attempt among patients with alcohol use disorders
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-07-18)Background<p> <p>Patients with alcohol use disorder (AUD) are at high risk for suicide attempts. Mental health problems along with AUD-related factors may contribute to this increased risk. Studies have shown sex differences in rates and correlates of suicide attempts. <p>Aims <p>The purpose of the study was to examine mental-health-related and AUD-related factors associated with suicide ... -
p62 and NDP52 Proteins Target Intracytosolic Shigella and Listeria to Different Autophagy Pathways
(Journal article; Tidsskriftartikkel; Peer reviewed, 2011-06-06)Autophagy is an important mechanism of innate immune defense. We have recently shown that autophagy components are recruited with septins, a new and increasingly characterized cytoskeleton component, to intracytosolic Shigella that have started to polymerize actin. On the other hand, intracytosolic Listeria avoids autophagy recognition by expressing ActA, a bacterial effector required for actin ... -
The Regulation of Steroid Receptor Co-activator-3 Activity by p38MAPK-MK2 Signaling Pathway
(Doctoral thesis; Doktorgradsavhandling, 2022-10-14)Steroid receptor co-activator-3 (SRC-3) is a co-activator that plays important roles in normal physiology and different diseases including cancer. Its activity is regulated by phosphorylation. Serine 857 (S857) is the most frequently reported phosphorylation site of SRC-3. In this work, we examined several kinases that could phosphorylate SRC-3 at S857 and explored the functional outcome incurred ... -
Factors shaping initial decision-making to self-test amongst cohabiting couples in urban Blantyre, Malawi
(Journal article; Tidsskriftartikkel; Peer reviewed, 2014-06-15)In sub-Saharan Africa, most new HIV infections occur in stable relationships, making couples testing an important intervention for HIV prevention. We explored factors shaping the decision-making of cohabiting couples who opted to self-test in Blantyre, Malawi. Thirty-four self-tested participants (17 couples) were interviewed. Motivators for HIV self-testing (HIVST) emerged at three main levels. ... -
Seroprevalence of SARS-Cov-2 Antibodies in Adults, Arkhangelsk, Russia
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-02)Population-based data on coronavirus disease in Russia and on the immunogenicity of the Sputnik V vaccine are sparse. In a survey of 1,080 residents of Arkhangelsk 40–75 years of age, 65% were seropositive for IgG. Fifteen percent of participants had been vaccinated; of those, 97% were seropositive. -
Leder - Ramazzini 2/2022
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022)I dette nummeret tar vi for oss prosjektarbeid i arbeids medisin som tema, med spesiell vekt på prosjekter I BHT. Men hva er egentlig prosjektarbeid? -
Forskning i BHT
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022)Arbeidsmedisinsk forskning må være relevant og svare på aktuelle utfordringer i samfunnet. Slik kommer faget fremover. Gjennom forankring i praksis kan nye problemstillinger fanges opp, hypoteser genereres og bedre løsninger skapes. Det inngår i et større bilde der økt samhandling mellom akademia og praksis etterspørres av myndighetene og aktørene selv. Det gjelder forøvrig også mange andre ... -
Nucleic acid peptide nanogels for the treatment of bacterial keratitis
(Journal article; Tidsskriftartikkel; Peer reviewed, 2020-08-14)Cage-shaped nucleic acid nanocarriers are promising molecular scaffolds for the organization of polypeptides. However, there is an unmet need for facile loading strategies that truly emulate nature's host–guest systems to drive encapsulation of antimicrobial peptides (AMPs) without loss of biological activity. Herein, we develop DNA nanogels with rapid in situ loading of L12 peptide during the thermal ... -
Comparability of plasma iohexol clearance across population-based cohorts
(Journal article; Tidsskriftartikkel; Peer reviewed, 2019-12-23)Rationale & Objective: Glomerular filtration rate (GFR) estimation based on creatinine or cystatin C level is currently the standard method for assessing GFR in epidemiologic research and clinical trials despite several important and well-known limitations. Plasma iohexol clearance has been proposed as an inexpensive method for measuring GFR that could replace estimated GFR in many research ... -
Risk factors associated with brain aging in the 7th Tromsø study
(Master thesis; Mastergradsoppgave, 2022-08-19)Introduction: Aging is a natural biological process characterized by a deterioration of functions on multiple levels: molecular, cellular, organ-specific, and systemic. There is considerable variation between individuals in aging based on biological and functional markers. This variation forms the basis for the idea of "biological age," which measures a more representative age than chronological ... -
«Hvilke erfaringer har behandlere på Voksenpsykiatrisk poliklinikk (VPP) med å vurdere henvisninger, særlig av ikke-vestlige innvandrere»
(Master thesis; Mastergradsoppgave, 2022-08-18)<p>Bakgrunn: Innvandrerbefolkning er en heterogen gruppe, og forekomsten av psykiske plager kan variere med hvor de kom fra, botid i Norge og innvandringsgrunn. De ikke-vestlige innvandrerne innbefatter flyktninger, asylsøkere, familiengjenforente og kvoteflyktninger. Opplevelse av krig og forfølgelse, traume og overgrep før og under flukt kan gjøre ikke-vestlige innvandrere mer sårbare for schizofreni ... -
Impact of spiritual healing on moderate depression in adults:a study protocol of a randomised controlled trial (RCT)
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-09-15)Introduction - Depression is a common mental disorder and the (global) leading cause of all non-fatal burden of disease worldwide. Currently, supported treatment for depression is antidepressant medication and different psychotherapeutic interventions. Many patients experience, however, adverse effects of antidepressant medication, while at the same time the access to psychotherapeutic interventions ... -
Fysisk aktivitet hos personer med alvorlig til dyp grad av utviklingshemming – tjenesteyternes erfaringer
(Master thesis; Mastergradsoppgave, 2021-12-10)Denne oppgaven handler om tjenesteyteres erfaringer med fysisk aktivitet for personer med alvorlig til dyp grad av utviklingshemming. Forskning viser at funksjonshemmede generelt opplever ulike barrierer når de deltar i samfunnet, men enda viktigere er det at personer med alvorlig til dyp grad av utviklingshemming opplever større utfordringer sammenlignet med den øvrige befolkningen. Litteraturgjennomgangen ... -
Å inkludere flyktninger i ordinært arbeidsliv - En studie av flyktningers erfaringer fra deltakelse i Introduksjonsprogrammet
(Master thesis; Mastergradsoppgave, 2021-05-18)Denne masteroppgaven er en kvalitativ studie som baserer seg på intervju av fem personer som har erfaring med å være deltakere Introduksjonsprogrammet. Et kvalifiseringsprogram for å inkludere flyktninger til arbeidsdeltakelse. Studien har en fenomenologisk tilnærming, og følgende problemstilling belyses: Hvilken kjennskap har flyktninger med høyere utdanning til hurtigsporsordningen? - En studie ... -
Establishment of an advanced flow cytometry protocol for analyzing immune cell subsets from lung cancer patients
(Mastergradsoppgave; Master thesis, 2022-08-22)Lymphocytes are known for their role in tumor promotion and tumor suppression. T cell infiltration of the tumor microenvironment has been linked to a better prognosis and outcome in various malignancies. CD8+ T cells can eliminate cancer cells by causing them to lyse, while CD4+ T cells can be both tumor promoting and tumor suppressing. However, the prognostic impact of functional lymphocyte subtypes ... -
Arbeid og utviklingshemming - "If there is a will, there is a way"! Arbeidsgivernes erfaringer med inkludering av mennesker med utviklingshemming i ordinære bedrifter.
(Master thesis; Mastergradsoppgave, 2021-05-15)Etter avviklingen av HVPU-omsorgen i Norge på 1990-tallet, har det vært store visjoner om at målet om høy arbeidsdeltakelse også skal gjelde for mennesker med utviklingshemming. Til tross for innsats og politiske mål, viser forskning at arbeidsdeltakelse for denne gruppen er synkende. Bare 25 prosent av voksne med utviklingshemming er i dag i arbeid, men de arbeider hovedsakelig i skjermede virksomheter ... -
Evaluering av implementeringen av RETHOS for studieprogrammene i tannpleie
(Research report; Forskningsrapport, 2022-02-22)Denne rapporten omhandler implementeringen av retningslinjene for helse- og sosialfagutdanningene, RETHOS.<p> <p>NOKUT har på oppdrag fra Kunnskapsdepartementet evaluert implementeringen av RETHOS gjennom tre ulike deler:<uli> <li>Kartlegging av etterlevelse av de nasjonale retningslinjene. Her presenteres det vurderinger fra sakkyndige om studieplanene ved institusjonene er i tråd med ... -
Improving public cancer care by implementing precision medicine in Norway: IMPRESS-Norway
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-05-14)Background: Matching treatment based on tumour molecular characteristics has revolutionized the treatment of some cancers and has given hope to many patients. Although personalized cancer care is an old concept, renewed attention has arisen due to recent advancements in cancer diagnostics including access to high-throughput sequencing of tumour tissue. Targeted therapies interfering with cancer ... -
A sustainability assessment framework for genome-edited salmon
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023)In this paper we present a suggestion for a sustainability assessment framework using genome editing of salmon as a case study. The salmon farming industry is facing several challenges hindering sustainable production. Genome editing has entered as a tool that can improve selective breeding and feed ingredients in aquaculture, hence providing solutions such as resistance to salmon lice and other ... -
Systemic family therapy for severe functional disorders in youths. A qualitative study in a psychiatric setting
(Journal article; Tidsskriftartikkel; Peer reviewed, 2021-01-15)This study aimed to explore participant experiences of systemic family therapy for youths with functional disorders. After completing family therapy, eight youths and thirteen parents participated in qualitative interviews. The analysis was based on interpretative phenomenological analysis and identified two main themes. The first theme was: ‘Challenges of creating meaning and understanding of child ...