Det helsevitenskapelige fakultet: Recent submissions
Now showing items 2661-2680 of 10429
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Senter for samisk helseforskning – en moden 20-åring
(Chapter; Bokkapittel, 2022-03-16)Senter for samisk helseforskning (SSHF) ble opprettet i 2001 av Sosial- og helsedepartementet med oppdrag om å framskaffe forskningsbasert kunnskap om helse og levekår i den samiske befolkninga i Norge. Gjennom 20 år har senterets ansatte publisert rundt 160 vitenskapelige artikler, og det er avlagt 17 doktorgrader. Det legges stor vekt på å gjøre kunnskapen tilgjengelig for befolkninga, noe denne ... -
Partnervold og psykiske plager – tidligere voldsutsatthet har betydning
(Chapter; Bokkapittel, 2022-03-16)Det finnes ingen tidligere studier som har hatt fokus på partnervold i den samisk befolkningen. Vi vet at vold generelt og partnervold spesielt påvirker den psykiske helsen negativt, og det er liten grunn til å tro at det er annerledes i samiske samfunn. Basert på data fra SAMINOR 2 – spørreskjemaundersøkelsen (2012), har vi studert forekomsten av emosjonell, fysisk og seksuell partnervold og ... -
Guktie mijjine? Gåktu viedjep? Movt mii veadjit? Hvordan har vi det?
(Book; Bok, 2022-03-16)Senter for samisk helseforskning ved UiT Norges arktiske universitet feirer 20 år og utgir i den forbindelse denne jubileumsboka. Boka inneholder 12 populærvitenskapelige kapitler som belyser helse og levekår i vårt flerkulturelle samfunn i Sápmi. Boka inneholder både norsk og samisk tekst. -
A novel dual-task paradigm for evaluating the interplay between gait, cognition, and hearing loss in normal aging and MCI: Effects of Dichotic Listening during overground walking
(Doctoral thesis; Doktorgradsavhandling, 2022-05-12)The association between gait and cognition in aging has been widely studied with the help of dual-task paradigms consisting of walking while simultaneously performing a cognitive task. However, previous dual-task research has lacked consistency in methods. In this doctoral work, we introduced a novel dual-task paradigm including Dichotic Listening (DL) performed concomitantly with walking overground. ... -
Cyclooxygenase-2 blockade can improve efficacy of VEGF-targeting drugs
(Journal article; Tidsskriftartikkel; Peer reviewed, 2015-01-31)Anti-angiogenic therapies were approved for different cancers. However, significant primary and secondary resistance hampers efficacy in several tumor types including breast cancer. Thus, we need to develop clinically applicable strategies to enhance efficacy of anti-angiogenic drugs. We report that anti-angiogenic therapies can induce upregulation of cyclooxygenase-2 (Cox-2) and of its product ... -
Yoik in Sami elderly and dementia care – A potential for a culture sensitive music therapy?
(Journal article; Tidsskriftartikkel; Peer reviewed, 2021-02-17)<p><i>Introduction:</i> The positive impact of familiar, individualized and patient-preferred music in dementia care is acknowledged in the literature. However, traditional indigenous music practices in care contexts are less studied. This study focuses on yoik, a traditional vocal music of the indigenous Sami people of Fennoscandia. The aims of this exploratory study were to investigate key ... -
Dna methylation-based subtype prediction for pediatric acute lymphoblastic leukemia
(Journal article; Tidsskriftartikkel; Peer reviewed, 2015-02-17)Background: We present a method that utilizes DNA methylation profiling for prediction of the cytogenetic subtypes of acute lymphoblastic leukemia (ALL) cells from pediatric ALL patients. The primary aim of our study was to improve risk stratification of ALL patients into treatment groups using DNA methylation as a complement to current diagnostic methods. A secondary aim was to gain insight into ... -
Epigenome-wide association study reveals decreased average methylation levels years before breast cancer diagnosis
(Journal article; Tidsskriftartikkel; Peer reviewed, 2015-08-04)Background: Interest in the potential of DNA methylation in peripheral blood as a biomarker of cancer risk is increasing. We aimed to assess whether epigenome-wide DNA methylation measured in peripheral blood samples obtained before onset of the disease is associated with increased risk of breast cancer. We report on three independent prospective nested case-control studies from the European ... -
Impact of smoking and smoking cessation on cardiovascular events and mortality among older adults: Meta-analysis of Individual participant data from prospective cohort studies of the CHANCES consortium
(Journal article; Tidsskriftartikkel; Peer reviewed, 2015-04-20)Objective To investigate the impact of smoking and smoking cessation on cardiovascular mortality, acute coronary events, and stroke events in people aged 60 and older, and to calculate and report risk advancement periods for cardiovascular mortality in addition to traditional epidemiological relative risk measures.<p> <p>Design Individual participant meta-analysis using data from 25 cohorts ... -
Cancer Research
(Journal article; Tidsskriftartikkel, 2017)American Association for Cancer Research was founded in 1907 by a group of 11 physicians and scientists interested in cancer research in the Washington, DC. Today, the AACR is the largest professional organization in the world with a membership of 37 000 researchers from 108 countries. This year, AAR Annual Meeting was organized from the 1th to 5th of April in the birthplace of the organization. I ... -
Musculoskeletal injury symptoms among hired Latinx child farmworkers in North Carolina
(Journal article; Tidsskriftartikkel; Peer reviewed, 2021-05-18)Background - Although children 10–17 years can be hired to work in agriculture, little research has addressed possible musculoskeletal injuries. Children may be at particular risk for these injuries because of the repetitive and load bearing nature of work tasks. Existing research relies on child workers to self-report musculoskeletal injuries.<p> <p>Methods - In 2017, 202 Latinx child farmworkers ... -
Detection of DHCMT long-term metabolite glucuronides with LC-MSMS as an alternative approach to conventional GC-MSMS analysis
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-02-17)Dehydrochloromethyltestosterone (DHCMT) is one of the most detected illicit used anabolic–androgenic steroids in professional sports. Therefore, a fast and accurate analysis of this substance is of great importance for a constructive fight against doping abuse. The conventional method for the analysis of this drug, GC-MSMS, is very sensitive and selective but also very time- and resource-consuming. ... -
Innlandsadopsjon blir automatisk problematisk når biologien gis forrang. (Debattinnlegg)
(Chronicle; Kronikk, 2022-02-20)Silje Førsund vil at vi får øynene opp for innenlandsadopsjon (Morgenbladet 10.02.22). Vi kan være enige i at det sannsynligvis er liten allmen bevissthet om innenlandsadopsjon i Norge sammenlignet med utenlandsadopsjon. Noen vil nok også si seg enige med Førsund i at «det er på høy tid at også stemmene til innenlandsadopterte i Norge blir hørt». Det er imidlertid flere forhold ved hennes innlegg ... -
Discovery and detection of phase-II metabolites of exogenous steroids in anti-doping analysis
(Doctoral thesis; Doktorgradsavhandling, 2022-04-29)Anti-doping measures are an essential part of professional sports around the world. Anabolic androgenic steroids have been among the most widely used illicit substance classes since the early days of the fight against doping. The conventional method for analysing these substances is gas chromatography combined with mass spectrometry (GC-MS). This approach is sensitive and selective but also very ... -
P62/sequestosome-1, autophagy-related gene 8, and autophagy in Drosophila are regulated by nuclear factor erythroid 2-related factor 2(NRF2), independent of transcription factor TFEB
(Journal article; Tidsskriftartikkel; Peer reviewed, 2015-04-30)The selective autophagy receptor p62/sequestosome 1 (SQSTM1) interacts directly with LC3 and is involved in oxidative stress signaling in two ways in mammals. First, p62 is transcriptionally induced upon oxidative stress by the NF-E2-related factor 2 (NRF2) by direct binding to an antioxidant response element in the p62 promoter. Second, p62 accumulation, occurring when autophagy is impaired, leads ... -
β-lactam and fluoroquinolone resistance in Enterobacteriaceae from imported and locally-produced chicken in Mozambique
(Journal article; Tidsskriftartikkel; Peer reviewed, 2020-05-31)Introduction: Plasmid-mediated resistance to β-lactam and fluoroquinolone antibiotics was investigated in Enterobacteriaceae isolated from retailed frozen chickens from Brazil, South Africa and Mozambique.<p> <p>Methodology: Carcass swabs and the liquid thaw of 33 chickens from each of the three countries constituted the total sample size of 198. Isolates were identified by biochemical tests, ... -
Creating Conditions for Professional Development Through a Trauma-Informed and Restorative Practice
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-02-02)Professionals in social work and nursing meet people who, due to trauma, struggle with the self-regulation of emotions and social behavior. Caring for trauma survivors requires connection and compassion. Previous research has indicated that many professionals, some with their own trauma histories, do not feel sufficiently equipped to practice self-care or cope with challenging communication. To ... -
The prognostic role of combining Krüppel-like factor 4 score and grade of inflammation in a Norwegian cohort of oral tongue squamous cell carcinomas
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-04-01)Krüppel-like factor 4 (KLF4) is a zinc-finger transcription factor involved in inflammation, cancer development, and progression. However, the relationship between KLF4, inflammation, and prognosis in oral cancer is not fully understood. KLF4 expression levels were examined in a multicenter cohort of 128 oral squamous cell carcinoma (OSCC) specimens from the tongue (OTSCC) using immunohistochemistry. ... -
Am I fine? Exploring everyday life ambiguities and potentialities of embodied sensations in a Danish middle-class community
(Journal article; Tidsskriftartikkel; Peer reviewed, 2016-04-21)Woven into the fabric of human existence is the possibility of death and suffering from disease. This essential vulnerability calls forth processes of meaning making, of grappling with uncertainty and morality. In this article we explore the uncertainty and ambiguity that exists in the space between bodily sensations and symptoms of illness. Bodily sensations have the potential to become symptoms ... -
Structural and functional analysis of a novel interaction motif within UFM1-activating enzyme 5 (UBA5) required for binding to ubiquitin-like proteins and ufmylation
(Journal article; Tidsskriftartikkel; Peer reviewed, 2016-02-29)The covalent conjugation of ubiquitin-fold modifier 1 (UFM1) to proteins generates a signal that regulates transcription, response to cell stress, and differentiation. Ufmylation is initiated by ubiquitin-like modifier activating enzyme 5 (UBA5), which activates and transfers UFM1 to ubiquitin-fold modifier-conjugating enzyme 1 (UFC1). The details of the interaction between UFM1 and UBA5 required ...