Focal adhesion kinase (FAK) is a central component of focal adhesions that regulate cancer cell proliferation and migration. Here, we studied the effects of FAK inhibition in glioblastoma (GBM), a fast growing brain tumor that has a poor prognosis. Treating GBM cells with the FAK inhibitor PF-573228 induced a proliferative arrest and increased cell size. PF-573228 also reduced the growth of GBM ...

<p><i>Background:</i> Multiple sclerosis (MS) is a severe chronic inflammatory disease in the central nervous system, mainly affecting young adults. The prevalence varies between different parts of the world, but the general rule is that it increases with increasing latitude. Studies on comorbid conditions in MS are limited, but this topic have gained increasing interest. <p><i>Aims:</i> To describe ...

<p><i>Background:</i> Knowledge of comorbid disorders is important to optimize therapy for multiple sclerosis (MS), but data are limited. The aim of this study was to assess comorbidity in persons with MS living in Nordland County on January 1, 2017. <p><i>Methods:</i> Data were retrieved from the Norwegian Patient Registry (2008-2017) and validated through review of electronic hospital charts ...

<p><i>Background/Aims:</i> Molar-Incisor Hypomineralization (MIH) is one of the most common dental developmental disorders with a global prevalence of 13%. The etiology of MIH is still elusive. The aims of this thesis were to report the prevalence of MIH in northern Norway, to investigate a possible association between birth asphyxia and MIH, and to document the effect of antibiotics on the developing ...

Background: The Coronary Revascularisation Outcome Questionnaire (CROQ) measures health-related quality of life and outcome of invasive revascularization procedures such as percutaneous coronary intervention (PCI) or coronary artery bypass grafting (CABG). The CROQ has not been properly validated in Norwegian patient populations. The aim of this study was to examine the psychometric properties ...

Enduring low energy availability (LEA) is associated with several potentially serious physiological and mental conditions. LEA has been found highly prevalent among female elite athletes within endurance sports, thus hampering athletes’ health and performance. The prevalence and the underpinning risk factors of LEA among female elite football players are less studied. One reason is that the existing ...

De fleste voksne i Norge (75 % av menn og 60 % av kvinner) er nå overvektige eller har fedme; de har kroppsmasseindeks (KMI) ≥ 25 kg/m2. Artikkelen gjør rede for gjennomsnittlig KMI og midjeomkrets og forekomsten av fedme – både generell fedme (KMI ≥ 30 kg/m2) og magefedme (midjeomkrets > 88 cm for kvinner og 102 cm for menn) – i SAMINOR-undersøkelsene som ble gjennomført i 2003–2004 og 2012–2014. ...

Introduction - The relevance of ecosystems to physiotherapy has traditionally been overlooked, despite its potential for health impacts relevant to conditions often managed by physiotherapists.<p> <p>Purpose - The purpose of this article is to introduce the concept of ecosystem services to physiotherapists, and to discuss how understanding ecosystem services may improve patient care, and population ...

NEAT1 is a highly abundant nuclear architectural long non-coding RNA. There are two overlapping NEAT1 isoforms, NEAT1_1 and NEAT1_2, of which the latter is an essential scaffold for the assembly of a class of nuclear ribonucleoprotein bodies called paraspeckles. Paraspeckle formation is elevated by a wide variety of cellular stressors and in certain developmental processes, either through transcriptional ...

Introduction<p> Antiphospholipid syndrome (APS) is a systemic autoimmune disease characterised by recurrent thrombotic events, pregnancy loss and thrombocytopenia and the presence of antiphospholipid antibodies (APL). The exact pathomechanism of APS is still unknown, thus we investigated the effect of anti-β2-glycoprotein I (anti-β2GPI) on thrombin generation in different plasma samples.<p> <p>Methods ...