Now showing items 2861-2880 of 10433

    • SAMM50 acts with p62 in piecemeal basal- and OXPHOS-induced mitophagy of SAM and MICOS components 

      Abudu, Yakubu Princely; Shrestha, Birendra Kumar; Zhang, Wenxin; Palara, Anthimi; Brenne, Hanne Britt; Larsen, Kenneth Bowitz; Wolfson, Deanna; Dumitriu, Gianina; Øie, Cristina Ionica; Ahluwalia, Balpreet Singh; Levy, Gahl; Behrends, Christian; Tooze, Sharon A; Mouilleron, Stephane; Lamark, Trond; Johansen, Terje (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-05-26)
      Mitophagy is the degradation of surplus or damaged mitochondria by autophagy. In addition to programmed and stress-induced mitophagy, basal mitophagy processes exert organelle quality control. Here, we show that the sorting and assembly machinery (SAM) complex protein SAMM50 interacts directly with ATG8 family proteins and p62/SQSTM1 to act as a receptor for a basal mitophagy of components of the ...
    • The association between meat and fish consumption and bladder cancer risk: a pooled analysis of 11 cohort studies 

      Dianatinasab, Mostafa; Wesselius, Anke; de Loeij, Tessa; Salehi-Abargouei, Amin; Yu, Evan Y. W.; Fararouei, Mohammad; Brinkman, Maree; van den Brandt, Piet; White, Emily; Weiderpass, Elisabete; Le Calvez-Kelm, Florence; Gunter, Marc J.; Huybrechts, Inge; Liedberg, Fredrik; Skeie, Guri; Tjonneland, Anne; Riboli, Elio; Zeegers, Maurice P. (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-05-25)
      Evidence on the effects of meat consumption from different sources on the risk of bladder cancer (BC) is limited and controversial. Therefore, this study aimed to evaluate the associations between meat consumption and BC risk using a pooled data approach. Individual data from 11 prospective cohorts comprising 2848 BC cases and 515,697 non-cases with a total of 5,498,025 person-years of follow-up was ...
    • Quantitative analysis methods for studying fenestrations in liver sinusoidal endothelial cells. A comparative study 

      Szafranska, Karolina; Holte, Christopher Florian; Kruse, Larissa Dorothea; Mao, Hong; Øie, Cristina Ionica; Symonski, Marek; Zapotoczny, Bartlomiej; McCourt, Peter Anthony (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-07-28)
      Liver Sinusoidal Endothelial Cells (LSEC) line the hepatic vasculature providing blood filtration via transmembrane nanopores called fenestrations. These structures are 50−300 nm in diameter, which is below the resolution limit of a conventional light microscopy. To date, there is no standardized method of fenestration image analysis. With this study, we provide and compare three different approaches: ...
    • The survival time of restorations is shortened in patients with dry mouth 

      Leinonen, Jukka; Vähänikkilä, Hannu; Raninen, Ellinoora; Järvelin, Laura; Näpänkangas, Ritva; Anttonen, Vuokko (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-09-03)
      Objectives - The aim of this retrospective data collection study was to determine the effect size of dry mouth on the survival of restorations and teeth.<p> <p>Methods - The data were collected from the electronic patient files of City of Oulu Public Dental Services (Finland). Study population consisted of 71 dry mouth patients and 142 control patients. The survival of 3208 restorations were ...
    • Cardiopulmonary Resuscitation and Rewarming from Accidental Hypothermia 

      Nilsen, Jan Harald (Doctoral thesis; Doktorgradsavhandling, 2022-03-11)
      This thesis springs from 3 different papers: Paper 1 A randomised controlled study in rats to investigate whether an infusion of crystalloids or colloids during rewarming from hypothermia could alleviate the alterations in cardiovascular function seen in untreated control animals. Paper 2 A randomised controlled study in pigs, examining normothermic vs hypothermic cardiopulmonary resuscitation (CPR). ...
    • Interplay of immune and kidney resident cells in the formation of tertiary lymphoid structures in lupus nephritis 

      Jamaly, Simin; Rakaee, Mehrdad; Abdi, Reza; tsokos, George; Fenton, Kristin Andreassen (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-10-27)
      Kidney involvement confers significant morbidity and mortality in patients with systemic lupus erythematosus (SLE). The pathogenesis of lupus nephritis (LN) involves diverse mechanisms instigated by elements of the autoimmune response which alter the biology of kidney resident cells. Processes in the glomeruli and in the interstitium may proceed independently albeit crosstalk between the two is ...
    • Drug-Drug-Gene Interactions: A Call for Clinical Consideration 

      Bruckmüller, Henrike; Cascorbi, Ingolf (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-07-18)
      It is widely accepted that both comedications and genetic factors may contribute to variation of drug response. Clinical decision support systems increasingly consider recommendations on drug– drug interactions (DDIs) during electronic prescribing, and some guidelines on drug–gene-interactions (DGI) have been implemented in drug labels. Potentially synergistically or antagonistically ...
    • Higher cognitive reserve is associated with better working memory performance and working-memory-related p300 modulation 

      Gutiérrez-Zamora Velasco, Gabriela; Fernández, Thalía; Silva-Pereyra, Juan; Reynoso-Alcántara, Vicenta; Castro Chavira, Susana Angelica (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-03-01)
      This study aims to examine how two levels of cognitive reserve, as evidenced by reading syntactic skill, modify performance and neural activity in a two-load-level (high vs. low) working memory (WM) task. Two groups of participants with different reading skills, high and low, were obtained from clustering analysis. We collected the P300 event-related potential component during the performance ...
    • Persuasion Tactics in the Implementation of f Large-Scale EHR Suites in Public Healthcare 

      Ellingsen, Gunnar; Christensen, Bente; Hertzum, Morten (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-11-08)
      Large-scale electronic health record (EHR) suites have the potential to cover a broad range of use needs across various healthcare domains. However, a challenge that must be solved is the distributed governance structure of public healthcare: Regional health authorities regulate hospitals, municipalities are responsible for first-line healthcare services, and general practitioners (GPs) have an ...
    • Novel human melanoma brain metastasis models in athymic nude fox1nu mice: Site-specific metastasis patterns reflecting their clinical origin 

      Svendsen, Henrik Aasrum; Meling, Torstein Ragnar; Nygaard, Vigdis; Waagene, Stein; Russnes, Hege Elisabeth Giercksky; Juell, Siri; Rogne, Siril Gudmundson; Pahnke, Jens; Helseth, Eirik; Fodstad, Øystein; Mælandsmo, Gunhild Mari (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-10-06)
      Background: Malignant melanomas frequently metastasize to the brain, but metastases in the cerebellum are underrepresented compared with metastases in the cerebrum.<p> <p>Methods: We established animal models by injecting intracardially in athymic nude fox1<sup>nu</sup> mice two human melanoma cell lines, originating from a cerebral metastasis (HM19) and a cerebellar metastasis (HM86).<p> <p>Results: ...
    • Alcohol consumption, cardiac biomarkers, and risk of atrial fibrillation and adverse outcomes 

      Csengeri, Dora; Sprünker, Ngoc-Anh; Di Castelnuovo, Augusto F; Niiranen, Teemu; Vishram-Nielsen, Julie K.K.; Costanzo, Simona; Soderberg, Stefan; Jensen, Steen M; Vartiainen, Erkki; Donati, Maria Benedetta; Magnussen, Christina; Camen, Stephan; Gianfagna, Francesco; Løchen, Maja-Lisa; Kee, Frank; Kontto, Jukka; Mathiesen, Ellisiv B.; Koenig, Wolfgang; Blankenberg, Stefan; de Gaetano, Giovanni; Jørgensen, Torben; Kuulasmaa, Kari; Zeller, Tanja; Salomaa, Veikko; Iacoviello, Licia; Schnabel, Renate B. (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-01-13)
      Aims<p> <p>There is inconsistent evidence on the relation of alcohol intake with incident atrial fibrillation (AF), in particular at lower doses. We assessed the association between alcohol consumption, biomarkers, and incident AF across the spectrum of alcohol intake in European cohorts.<p> <p>Methods and results <p> In a community-based pooled cohort, we followed 107 845 individuals for the ...
    • Remote Monitoring of CIEDs—For Both Safety, Economy and Convenience? 

      Lappegård, Knut Tore; Moe, Frode (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-12-28)
      Cardiac implantable electronic devices such as pacemakers and defibrillators are increasingly monitored by systems transmitting information directly from the patient to the hospital. This may increase safety and patient satisfaction and also under certain circumstances represent an economic advantage. The review summarizes some of the recent research in the field of remote monitoring of cardiac devices.
    • Sperm mitochondrial DNA copy numbers in normal and abnormal semen analysis: A systematic review and meta-analysis 

      Popova, Daria; Bhide, Priya; D’Antonio, Francesco; Basnet, Purusotam; Acharya, Ganesh (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-12-25)
      Background: Normal mature sperm have a considerably reduced number of mitochondria, which provide the energy required for progressive sperm motility. Literature suggests that disorders of sperm motility may be linked to abnormal sperm mitochondrial number and function.<p> <p>Objectives: To summarise the evidence from literature regarding the association of mitochondrial DNA copy numbers and semen ...
    • Clinical Decision Support Systems for Child Neuropsychiatric Disorders: The Time Has Come? 

      Koposov, Roman A; Frodl, Thomas; Nytrø, Øystein; Leventhal, Bennett; Sourander, Andre; Quaglini, Silvana; Molteni, Massimo; de la Iglesia Vayá, María; Ulrich Prokosch, Hans; Barbarini, Nicola; Milham, Michael Peter; Skokauskas, Norbert; Castellanos, Francisco Xavier (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-04-10)
      Great advances in molecular biology, genetics and imaging serve to enhance the desire to develop multi-level and multi-scale models for "personalized medicine" but they remain very challenging for high prevalence, high impact childhood onset neuropsychiatric disorders. We currently have the capacity to develop innovative, effective and efficient clinical decision support models, while also creating ...
    • Association between Diet and Xerostomia: Is Xerostomia a Barrier to a Healthy Eating Pattern? 

      Stankeviciene, Indre; Aleksejuniene, Jolanta; Puriene, Alina; Stangvaltaite-Mouhat, Lina (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-11-25)
      Objective. Xerostomia is a subjective feeling of dry mouth and is commonly observed in patients with autoimmune diseases. Our study examines the association between xerostomia and diet. Materials and Methods. The cross-sectional study includes 1405 adults from 15 Lithuanian geographical areas (52% response rate). A self-reported questionnaire inquired about xerostomia, sex, age, education, ...
    • Prior Prognostic Expectations as a Potential Predictor in Neurofeedback Training. 

      Damanskyy, Yevhen; Olsen, Alexander; Hollup, Stig Arvid (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-11-29)
      The present study evaluated whether subjects’ expectations and neurofeedback training performance predict neurofeedback efficacy in cognitive training by controlling both factors as statistical variables. Twenty-two psychology students underwent neurofeedback training, employing beta/theta protocol to enhance beta1 power (13–21 Hz) and suppress theta (4–7 Hz) power. Neurofeedback efficacy was evaluated ...
    • Autofluorescence in freshly isolated adult human liver sinusoidal cells 

      Larsen, Anett Kristin; Simon-Santamaria, Jaione; Elvevold, Kjetil; Ericzon, Bo Gøran; Mortensen, Kim Erlend; McCourt, Peter Anthony; Smedsrød, Bård; Sørensen, Karen Kristine (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-12-13)
      Autofluorescent granules of various sizes were observed in primary human liver endothelial cells (LSECs) upon laser irradiation using a wide range of wavelengths. Autofluorescence was detected in LAMP-1 positive vesicles, suggesting lysosomal location. Confocal imaging of freshly prepared cultures and imaging flow cytometry of non-cultured cells revealed fluorescence in all channels used. Treatment ...
    • Serological evidence of hepatitis e virus infection in semi-domesticated eurasian tundra reindeer (Rangifer tarandus tarandus) in norway 

      Rinaldo, Christine Hanssen; Nymo, Ingebjørg Helena; Sanchez Romano, Javier; Breines, Eva Marie; Murguzur, Francisco Javier Ancin; Tryland, Morten (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-11-25)
      Hepatitis E virus (HEV) is a common cause of viral hepatitis in humans. In developing countries, HEV-infections seem to be mainly associated with pigs, but other animal species may be involved in viral transmission. Recently, anti-HEV antibodies were detected in Norwegian wild reindeer. Here, we investigated anti-HEV seroprevalence in Norwegian semi-domesticated reindeer, animals in closer contact ...
    • No significant histological or ultrastructural tendinosis changes in the hamsting tendon in patients with mild to moderate osteoarthritis of the knee? 

      Ibrahim, Mustafa; Meknas, Khaled; Steigen, Sonja Eriksson; Olsen, Randi; Sernert, Ninni; Ejerhed, Lars; Kartus, Juri-Toomas (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-06-20)
      Purpose To investigate the periarticular degenerative changes of the knee joint in association with osteoarthritis (OA). More tendinosis was expected to be found in the semitendinosus tendon in patients with knee OA than in patients without knee OA.<p> Methods Samples from 41 patients were included between January 2016 and October 2017. Twenty-one patients median age 53 (33–63) years with mild ...
    • Polyphenol Intake and Epithelial Ovarian Cancer Risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) Study 

      Londono, Catalina; Cayssials, Valerie; de Villasante, Izar; Crous-Bou, Marta; Scalbert, Augustin; Weiderpass, Elisabete; Agudo, Antonio; Tjønneland, Anne; Olsen, Anja; Overvad, Kim; Katzke, Verena; Schulze, Matthias; Palli, Domenico; Krogh, Vittorio; De Magistris, Maria Santucci; Tumino, Rosario; Ricceri, Fulvio; Gram, Inger Torhild; Rylander, Charlotta; Skeie, Guri; Sanchez, Maria-Jose; Amiano, Pilar; Huerta, José María; Barricarte, Aurelio; Sartor, Hanna; Sonestedt, Emily; Esberg, Anders; Idahl, Annika; Mahamat-Saleh, Yahya; Laouali, Nasser; Kvaskoff, Marina; Turzanski-Fortner, Renée; Zamora-Ros, Raul (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-08-04)
      Despite some epidemiological evidence on the protective effects of polyphenol intake on epithelial ovarian cancer (EOC) risk from case-control studies, the evidence is scarce from prospective studies and non-existent for several polyphenol classes. Therefore, we aimed to investigate the associations between the intake of total, classes and subclasses of polyphenols and EOC risk in a large ...