Det helsevitenskapelige fakultet: Recent submissions

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    • The Incidence of Stroke in Indigenous Populations of Countries With a Very High Human Development Index: A Systematic Review Protocol 

      Balabanski, Anna H.; Dos Santos, Angela; Woods, John A.; Thrift, Amanda G.; Kleinig, Timothy J.; Suchy-Dicey, Astrid; Siri, Susanna Ragnhild; Boden-Albala, Bernadette; Krishnamurthi, Rita V.; Feigin, Valery L.; Buchwald, Dedra; Ranta, Anna; Mienna, Christina S.; Zavaleta, Carol; Churilov, Leonid; Burchill, Luke; Zion, Deborah; Longstreth, W.T.; Tirschwell, David L.; Anand, Sonia; Parsons, Mark W.; Brown, Alex; Warne, Donald K.; Harwood, Matire; Katzenellenbogen, Judith M. (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-04-22)
      Background and Aims: Despite known Indigenous health and socioeconomic disadvantage in countries with a Very High Human Development Index, data on the incidence of stroke in these populations are sparse. With oversight from an Indigenous Advisory Board, we will undertake a systematic review of the incidence of stroke in Indigenous populations of developed countries or regions, with comparisons between ...

    • Air Bubbles Activate Complement and Trigger Hemostasis and C3-Dependent Cytokine Release Ex Vivo in Human Whole Blood 

      Storm, Benjamin; Christiansen, Dorte; Fure, Hilde; Ludviksen, Judith K; Lau, Corinna; Lambris, John D.; Woodruff, Trent M.; Brekke, Ole-Lars; Braaten, Tonje Bjørndal; Nielsen, Erik Waage; Mollnes, Tom Eirik (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-11-03)
      Venous air embolism, which may complicate medical and surgical procedures, activates complement and triggers thromboinflammation. In lepirudin-anticoagulated human whole blood, we examined the effect of air bubbles on complement and its role in thromboinflammation. Whole blood from 16 donors was incubated with air bubbles without or with inhibitors of C3, C5, C5aR1, or CD14. Complement activation, ...

    • Covid-19 pandemic lessons: uncritical communication of test results can induce more harm than benefit and raises questions on standardized quality criteria for communication and liability 

      Porzsolt, Franz; Pfuhl, Gerit; Kaplan, Robert M; Eisemann, Martin (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-09-21)
      Background - The COVID-19 pandemic is characterized by both health and economic risks. A ‘safety loop’ model postulates risk-related decisions are not based on objective and measurable risks but on the subjective perception of those risks. We here illustrate a quantification of the difference between objective and subjective risks.<p> <p>Method - The objective risks (or chances) can be obtained ...

    • Positron emission tomography and single photon emission computed tomography imaging of tertiary lymphoid structures during the development of lupus nephritis 

      Dorraji, Seyed Esmaeil; Oteiza, Ana; Kuttner, Samuel; Martin, Armas Maria Montserrat; Kanapathippillai, Premasany; Garbarino, Sara; Kalda, Gustav; Scussolini, Mara; Piana, Michele; Fenton, Kristin Andreassen (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-08-03)
      Lymphoid neogenesis occurs in tissues targeted by chronic inflammatory processes, such as infection and autoimmunity. In systemic lupus erythematosus (SLE), such structures develop within the kidneys of lupus-prone mice ((NZBXNZW)F1) and are observed in kidney biopsies taken from SLE patients with lupus nephritis (LN). The purpose of this prospective longitudinal animal study was to detect early ...

    • Plasma levels of leptin and risk of future incident venous thromboembolism 

      Frischmuth, Tobias; Hindberg, Kristian; Aukrust, Pål; Ueland, Thor; Brækkan, Sigrid K.; Hansen, John-Bjarne; Morelli, Vania Maris (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-07-11)
      Background - Circulating levels of leptin, an adipocyte-derived hormone, are frequently elevated in obesity. Leptin has been reported to upregulate prothrombotic hemostatic factors in vitro and could potentially mediate venous thromboembolism (VTE) risk in obesity. However, whether leptin is associated with VTE remains uncertain.<p> <p>Objective - This article investigates the association between ...

    • Associations Between Intake of Fermented Dairy Products and Blood Lipid Concentrations Are Affected by Fat Content and Dairy Matrix - The Tromsø Study: Tromsø7 

      Machlik, Monika Lund; Hopstock, Laila Arnesdatter; Wilsgaard, Tom; Hansson, Patrik (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-11-22)
      Introduction: Dairy fat is rich in saturated fatty acids known to increase serum low-density lipoprotein cholesterol (LDL-C) concentration, an important risk factor for cardiovascular disease (CVD). However, intake of fermented dairy products has been associated with reduced CVD risk in observational studies. How intakes of different fermented dairy products are associated with blood lipid concentrations ...

    • Aberrant salience predicts fluctuations of paranoia two weeks in advance during a 1-year experience sampling method study in people with psychosis 

      Luedtke, Thies; Moritz, Steffen; Westermann, Stefan; Pfuhl, Gerit (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-12-03)
      The Experience Sampling Method (ESM) has improved our understanding of psychosis considerably (Myin-Germeys et al., 2018). Not only has ESM shed light on the moment-to-moment variability of psychotic symptoms, it has equally helped to identify micro-level precursor variables that forecast symptom exacerbations a couple of hours in advance. Among others, established ESM-derived precursors are negative ...

    • Evidence basis for injury prevention in Northwestern Russia: a study from the Population-based Shenkursk Injury Registry 

      Unguryanu, Tatiana Nikolaevna (Doctoral thesis; Doktorgradsavhandling, 2022-02-25)
      Injuries are the important public health problem worldwide. Good-quality injury data are necessary for the development of effective prevention. The Shenkursk Injury Registry (SHIR) was established in the Shenkursk District, Northwestern Russia in 2015. The SHIR covers all injuries for which medical aid is given at the Shenkursk central district hospital (CDH). Overall aim was to provide an evidence ...

    • Low pain tolerance is associated with coronary angiography, coronary artery disease, and mortality: The TROMSO study 

      Fladseth, Kristina; Lindekleiv, Haakon; Nielsen, Christopher Sivert; Øhrn, Andrea; Kristensen, Andreas; Mannsverk, Jan Torbjørn; Løchen, Maja-Lisa; Njølstad, Inger; Wilsgaard, Tom; Mathiesen, Ellisiv B.; Stubhaug, Audun; Trovik, Thor; Rotevatn, Svein; Forsdahl, Signe Helene; Schirmer, Henrik (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-11-03)
      BACKGROUND: The initial presentation to coronary angiography and extent of coronary artery disease (CAD) vary greatly among patients, from ischemia with no obstructive CAD to myocardial infarction with 3-vessel disease. Pain tolerance has been suggested as a potential mechanism for the variation in presentation of CAD. We aimed to investigate the association between pain tolerance, coronary ...

    • Does the Stereotypicality of Mothers’ Occupation Influence Children’s Communal Occupational Aspirations and Communal Orientation? 

      Kvalø, Marie; Marte, Olsen; Thorsteinsen, Kjærsti; Olsson, Maria; Martiny, Sarah E. (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-12-16)
      Career development is a lifelong process that starts in infancy and is shaped by a number of different factors during childhood, adolescence, and adulthood. Even though career development is shaped through life, relatively little is known about the predictors of occupational aspirations in childhood. Therefore, in the present work we investigate how the stereotypicality of a mother’s occupation ...

    • Reindriftssamer har pleie- og omsorgsbehov i to kommuner 

      Eira, June Brita; Mehus, Grete (Journal article; Tidsskriftartikkel, 2022-01-23)
      Hensikten med artikkelen er å belyse en kommunes erfaringer med å samhandle og vurdere behov for pleie- og omsorgstjenester for samiske pasienter som tilhører reindriften og kommer til sommerhjemmet. Dette er en viktig problemstilling med tanke på reindriftssamenes rett til likeverdige helsetjenester uavhengig av hvor de oppholder seg.

    • Risk scores for prediction of 30-day mortality after transcatheter aortic valve implantation: Results from a two-center study in Norway 

      Kjønås, Didrik; Schirmer, Henrik; Malm, Siri; Eidet, Jo; Aaberge, Lars; Steigen, Terje; Aakhus, Svend; Busund, Rolf; Røsner, Assami; Dahle, Gry (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-05-06)
      Objectives: Transcatheter aortic valve implantation (TAVI)-specific risk scores have been developed based on large registry studies. Our aim was to evaluate how both surgical and novel TAVI risk scores performed in predicting all cause 30-day mortality. In addition, we wanted to explore the validity of our own previously developed model in a separate and more recent cohort.<p> <p>Methods: The ...

    • Distress, problems and unmet rehabilitation needs after treatment for gynecological cancer 

      Selland, Mette; Skrede, Katrine; Lindemann, Kristina Yvonne Kathe; Skaali, Tone Margrethe Olsbu; Blomhoff, Rune; Bruheim, Kjersti; Wisløff, Torbjørn; Thorsen, Lene (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-12-29)
      Introduction - The prevalence of distress, problems and need for rehabilitation among women treated for gynecological cancer is largely unknown. The aims of this study were to examine the prevalence of distress, problems and unmet rehabilitation needs in the first years after treatment for gynecological cancer.<p> <p>Material and methods - Women treated for gynecological cancer within the last 2 ...

    • RESTAMP – Rate estimates by sequence-tag analysis of microbial populations 

      Mahmutovic, Anel; Gillman, Aaron Nicholas; Lauksund, Silje; Robson Moe, Natasha-Anne; Manzi, Aimé; Storflor, Merete; Abel-Zur Wiesch Genannt Hülsho, Pia Karoline; Abel, Sören (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-01-19)
      Microbial division rates determine the speed of mutation accumulation and thus the emergence of antimicrobial resistance. Microbial death rates are affected by antibiotic action and the immune system. Therefore, measuring these rates has advanced our understanding of host-pathogen interactions and antibiotic action. Several methods based on marker-loss or few inheritable neutral markers exist that ...

    • Serum Matrix Metalloproteinase 7 and accelerated glomerular filtration rate decline in a general non-diabetic population 

      Enoksen, Inger Therese T.; Svistounov, Dmitri; Norvik, Jon Viljar; Stefansson, Vidar Tor Nyborg; Solbu, Marit Dahl; Eriksen, Bjørn Odvar; Melsom, Toralf (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-08-26)
      Background. Age-related reduction of glomerular filtration rate (GFR) is a major contributor to the global chronic kidney disease (CKD) epidemic. We investigated whether baseline serum levels of the pro-fibrotic matrix metalloproteinase 2 (MMP2), MMP7 and their inhibitor, tissue inhibitor of metalloproteinase 1 (TIMP1), which mediates fibrosis development in aging animals, were associated with ...

    • Associations between cervical dilatation on admission and mode of delivery, a cohort study of Norwegian nulliparous women 

      Gjærum, Ragnhild; Johansen, Ingvild; Øian, Pål; Bernitz, Stine; Dalbye, Rebecka (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-12-16)
      Objective - To investigate associations between cervical dilatation at hospital admission and mode of delivery.<p> <p>Methods - A cohort study with data from a cluster-randomised controlled trial, the Labour Progression Study. The study population of 6511 nulliparous women with a singleton fetus in cephalic presentation with spontaneous onset of labour at term, was divided into two groups: <4 cm ...

    • A Nationwide Study of GATA2 Deficiency in Norway-the Majority of Patients Have Undergone Allo-HSCT 

      Jørgensen, Silje Fjellgård; Buechner, Jochen; Myhre, Anders E.; Galteland, Eivind; Spetalen, Signe; Kulseth, Mari Ann; Sorte, Hanne Sørmo; Holla, Øystein Lunde; Lundman, Emma; Alme, Charlotte; Heier, Ingvild; Flægstad, Trond; Fløisand, Yngvar; Benneche, Andreas; Fevang, Børre; Aukrust, Pål; Stray-Pedersen, Asbjørn; Gedde-Dahl, Tobias; Nordøy, Ingvild (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-12-10)
      Purpose: GATA2 deficiency is a rare primary immunodeficiency that has become increasingly recognized due to improved molecular diagnostics and clinical awareness. The only cure for GATA2 deficiency is allogeneic hematopoietic stem cell transplantation (allo-HSCT). The inconsistency of genotype-phenotype correlations makes the decision regarding "who and when" to transplant challenging. Despite ...

    • Impact of maturation on myocardial response to ischemia and the effectiveness of remote preconditioning in male rats 

      Kindernay, Lucia; Farkasova, Veronika; Neckar, Jan; Hrdlicka, Jaroslav; Ytrehus, Kirsti; Ravingerova, Tanya (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-10-12)
      Aging attenuates cardiac tolerance to ischemia/reperfusion (I/R) associated with defects in protective cell signaling, however, the onset of this phenotype has not been completely investigated. This study aimed to compare changes in response to I/R and the effects of remote ischemic preconditioning (RIPC) in the hearts of younger adult (3 months) and mature adult (6 months) male Wistar rats, with ...

    • Aspirin as secondary prevention in colorectal cancer liver metastasis (ASAC trial): study protocol for a multicentre randomized placebo-controlled trial 

      Yaqub, Sheraz; Bjørnbeth, Bjørn Atle; Angelsen, Jon-Helge; Fristrup, Claus W.; Grønbech, Jon Erik; Hemmingsson, Oskar; Isaksson, Bengt; Juel, Ingebjørg Soterud; Larsen, Peter Nørgaard; Lindell, Gert; Mortensen, Frank V.; Mortensen, Kim Erlend; Rizell, Magnus; Sandström, Per; Sandvik, Oddvar Mathias; Sparrelid, Ernesto; Taflin, Helena; Taskén, Kjetil; Brudvik, Kristoffer Watten; Fretland, Åsmund Avdem; Horn, Arild; Kleive, Dyre; Labori, Knut Jørgen; Lassen, Kristoffer; Røsok, Bård Ingvald; Søreide, Jon Arne; Tholfsen, Tore; Villanger, Olaug; Waage, Anne (Journal article; Tidsskriftartikkel, 2021-09-20)
      Background: Colorectal cancer is one the most common cancers in the western world with increasing incidence. Approximately 50% of the patients develop liver metastases. Resection of liver metastases is the treatment of choice although almost half of the resected patients get recurrence in the liver. Methods: The ASAC trial is a Scandinavian, multicentre, double-blinded, randomized, placebo-controlled ...

    • Dental anxiety and potentially traumatic events: a cross-sectional study based on the Tromsø Study—Tromsø 7 

      Nermo, Hege; Willumsen, Tiril; Rognmo, Kamilla; Thimm, Jens; Wang, Catharina Elisabeth Arfwedson; Johnsen, Jan-Are Kolset (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-11-23)
      Objective: The objectives of the study were to describe the prevalence of dental anxiety and the possible associa‑ tions between dental anxiety and potentially traumatic events in an adult population.<p> <p>Method: The study is based on cross-sectional questionnaire data from the 7th wave of the Tromsø Study, a study of the adult general population in the municipality of Tromsø carried out in ...