Det helsevitenskapelige fakultet: Recent submissions

Now showing items 3021-3040 of 10438

    • Chronic kidney disease in patients with diabetes mellitus 

      Nordheim, Espen; Jenssen, Trond Geir (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-04-29)
      Chronic kidney disease is a common complication and concomitant condition of diabetes mellitus. The treatment of patients with diabetes and chronic kidney disease, including intensive control of blood sugar and blood pressure, has been very similar for type 1 and type 2 diabetes patients. New therapeutic targets have shown promising results and may lead to more specific treatment options for patients ...

    • Prioritized brain circulation during ergometer cycling with apnea and face immersion in ice-cold water: A case report 

      Bjertnaes, Lars J.; Hauge, Anton; Thoresen, Marianne; Walløe, Lars (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-09-24)
      Background: Successful cardiopulmonary resuscitation after drowning or avalanche is often attributed to hypothermia-induced decrease in metabolism, which adapts the oxygen demand to the amount supplied under cardiac compression. Four decades ago, we speculated if oxygen-sparing mechanisms like those found in marine mammals, may improve cerebral oxygenation during acute airway blockade in humans. We ...

    • Rehabilitering og sekundærforebygging etter hjerteinfarkt ved sykehus 

      Peersen, Kari; Munkhaugen, John; Olsen, Siv Jorunn Storli; Otterstad, Jan Erik; Sverre, Elise Christine Bjørkholen (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-10-25)
      BAKGRUNN I norske studier er det dokumentert dårlig kardiovaskulær risikofaktorkontroll og høy forekomst av nye hjerte- og karhendelser hos hjerteinfarktpasienter. Det foreligger lite kunnskap om omfang av sekundærforebyggende behandling og hjerterehabilitering ved norske sykehus. Vi ønsket derfor å gjennomføre en kartlegging av rutiner ved utskrivning og poliklinisk oppfølging etter hjerteinfark ...

    • Kjerneområder i Leve hele livet-reformen. En oppsummering av kunnskap om frivillighet, pårørende, medvirkning og digital kompetanse 

      Ambugo, Eliva Atieno; Andfossen, Nina Beate; Cappelen, Kathrine; Dale, Bjørg; Devik, Siri Andreassen; Fredwall, Terje Emil; Hartviksen, Trude Anita; Jacobsen, Frode F.; Kvaal, Bjørn; Løkken, Bente Irene; Melby, Line; Moe, Aud; Nilsen, Elin Rogn; Solstad, Liv Jorunn; Solvoll, Betty Ann Ragnhild; Strøm, Benedicte Sørensen; Sundsbø, Astrid (Research report; Forskningsrapport, 2021-11)
      Leve hele livet er en kvalitetsreform for eldre. Målet med den er at alle eldre skal få bedre hjelp og støtte til å mestre livet. Reformen handler om de grunnleggende tingene som oftest svikter i tilbudet til eldre: mat, aktivitet og fellesskap, helsehjelp og sammenheng i tjenestene.<p> <p>Senter for omsorgsforskning har utarbeidet denne og flere kunnskapsnotater på oppdrag fra Helsedirektoratet. ...

    • COVID-19 preparedness—a survey among neonatal care providers in low- and middle-income countries 

      Klingenberg, Claus; Tembulkar, Sahil K.; Lavizzari, Anna; Roehr, Charles Christoph; Ehret, Danielle E.Y.; Vain, Nestor Eduardo; Mariani, Gonzalo Luis; Erdeve, Ömer; Lara-Diaz, Victor Javier; Velaphi, Sithembiso; Cheong, Hon Kin; Bisht, Surender Singh; Waheed, Khawaja Ahmad Irfan; Stevenson, Alexander G.; Al-Kafi, Nisreen; Roue, Jean-Michel; Barrero-Castillero, Alejandra; Molloy, Eleanor J.; Zupancic, John A.F.; Profit, Jochen (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-04-13)
      Objective - To evaluate COVID-19 pandemic preparedness, available resources, and guidelines for neonatal care delivery among neonatal health care providers in low- and middle-income countries (LMICs) across all continents.<p> <p>Study design - Cross-sectional, web-based survey administered between May and June, 2020.<p> <p>Results - Of 189 invited participants in 69 LMICs, we received 145 (77%) ...

    • Study Habits and Procrastination: The Role of Academic Self-Efficacy 

      Svartdal, Frode; Sæle, Rannveig Grøm; Dahl, Tove I.; Nemtcan, Efim; Gamst-Klaussen, Thor (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-08-03)
      Inefficient study skills increase the probability that study work is perceived as difficult and aversive, with procrastination as a likely result. As a remedy, more effective study skills and habits may be encouraged. However, research indicates that good study skills and habits may not by themselves be sufficient to remedy problems, as this relationship may be mediated by efficacy beliefs related ...

    • Environmental physiotherapy and the case for multispecies justice in planetary health 

      Maric, Filip; Nicholls, David A. (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-08-07)
      Background:Global environmental change is fundamentally altering the composition and functioning of our planetary ecosystem. Effectively presenting the largest threat to the health of present and future generations, these changes and their health impacts are forcing us to think and practice healthcare in much broader terms than ever before. Objective:In this article, we provide an early outline for ...

    • A combination of infraclavicular and suprascapular nerve blocks for total shoulder arthroplasty: A case series 

      Musso, Dario Davide; Klaastad, Øivind; Ytrebø, Lars Marius (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-01-27)
      Background - Shoulder arthroplasty is associated with significant post-operative pain. Interscalene plexus block is the gold standard for pain management in patients undergoing this surgery, however, alternatives are currently being developed. We hypothesized that a combination of anterior suprascapular nerve block and lateral sagittal infraclavicular block would provide effective post-operative ...

    • Increased sensitivity to SMAC mimetic LCL161 identified by longitudinal ex vivo pharmacogenomics of recurrent, KRAS mutated rectal cancer liver metastases 

      Kryeziu, Kushtrim; Moosavi, Seyed Hossein; Bergsland, Christian Holst; Guren, Marianne; Eide, Peter Andreas Wold; Totland, Max; Lassen, Kristoffer; Abildgaard, Andreas; Nesbakken, Arild; Sveen, Anita; Lothe, Ragnhild Adelheid (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-09-08)
      Tumor heterogeneity is a primary cause of treatment failure. However, changes in drug sensitivity over time are not well mapped in cancer. Patient-derived organoids (PDOs) may predict clinical drug responses ex vivo and ofer an opportunity to evaluate novel treatment strategies in a personalized fashion. Here we have evaluated spatio-temporal functional and molecular dynamics of fve PDO models ...

    • Association of glycated hemoglobin A1c levels with cardiovascular outcomes in the general population: results from the BiomarCaRE (Biomarker for Cardiovascular Risk Assessment in Europe) consortium 

      Sinning, Christoph; Makarova, Nataliya; Völzke, Henry; Schnabel, Renate B.; Ojeda, Francisco; Dörr, Marcus; Felix, Stephan B.; Koenig, Wolfgang; Peters, Annette; Rathmann, Wolfgang; Schöttker, Ben; Brenner, Hermann; Veronesi, Giovanni; Cesana, Giancarlo; Brambilla, Paolo; Palosaari, Tarja; Kuulasmaa, Kari; Njølstad, Inger; Mathiesen, Ellisiv B.; Wilsgaard, Tom; Blankenberg, Stefan; Söderberg, Stefan; Ferrario, Marco M.; Thorand, Barbara (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-11-15)
      Background: Biomarkers may contribute to improved cardiovascular risk estimation. Glycated hemoglobin A<sub>1c</sub> (HbA<sub>1c</sub>) is used to monitor the quality of diabetes treatment. Its strength of association with cardiovascular outcomes in the general population remains uncertain. This study aims to assess the association of HbA<sub>1c</sub> with cardiovascular outcomes in the general ...

    • Psychoactive substances have major impact on injuries in rural arctic Norway – A prospective observational study 

      Wilson, Thomas; Wisborg, Torben; Vindenes, Vigdis; Jamt, Ragnhild G.; Furuhaugen, Håvard; Bogstrand, Stig Tore (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-02-27)
      Background - Rural areas have increased injury mortality with a high pre-hospital death rate. Knowledge concerning the impact of psychoactive substances on injury occurrence is lacking for rural arctic Norway. These substances are also known to increase pre-, per- and postoperative risk. The aim was by prospective observational design to investigate the prevalence and characteristics of psychoactive ...

    • Response to Letter to the Editor from Dalan: "Vitamin D Supplementation for Prevention of Type 2 Diabetes Mellitus: To D or Not to D?" 

      Pittas, Anastassios G.; Jorde, Rolf; Kawahara, Tetsuya; Dawson-Hughes, Bess (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-12-30)
      We thank Rinkoo Dalan for the comments on our paper (1, 2). We agree that although the reduction in diabetes risk with vitamin D supplementation among people at high risk for diabetes appears to be moderate (~ 12% relative risk reduction compared to placebo) (3), certain individuals may derive a higher (or lower) benefit based on certain characteristics. For example, in the simplest demonstration ...

    • Protein Appetite Drives Macronutrient-Related Differences in Ventral Tegmental Area Neural Activity 

      Chiacchierini, Giulia; Naneix, Fabien; Peters, Kate Z; Aspergis-Schoute, John; Snoeren, Eelke; McCutcheon, James Edgar (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-06-09)
      Control of protein intake is essential for numerous biological processes as several amino acids cannot be synthesized de novo, however, its neurobiological substrates are still poorly understood. In the present study, we combined in vivo fiber photometry with nutrient-conditioned flavor in a rat model of protein appetite to record neuronal activity in the VTA, a central brain region for the control ...

    • External validation of a deep learning electrocardiogram algorithm to detect ventricular dysfunction 

      Attia, Itzhak Zachi; Tseng, Andrew S.; Benavente, Ernest Diez; Medina-Inojosa, Jose R.; Clark, Taane; Malyutina, Sofia; Kapa, Suraj; Schirmer, Henrik; Kudryavtsev, Alexander V; Noseworthy, Peter A.; Carter, Rickey E.; Ryabikov, Andrey; Perel, Pablo; Friedman, Paul A.; Leon, David A.; Lopez-Jimenez, Francisco (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-01-02)
      Objective - To validate a novel artificial-intelligence electrocardiogram algorithm (AI-ECG) to detect left ventricular systolic dysfunction (LVSD) in an external population.<p> <p>Background - LVSD, even when asymptomatic, confers increased morbidity and mortality. We recently derived AI-ECG to detect LVSD using ECGs based on a large sample of patients treated at the Mayo Clinic.<p> <p>Methods ...

    • Stratification of Culture-Proven Early-Onset Sepsis Cases by the Neonatal Early-Onset Sepsis Calculator: An Individual Patient Data Meta-Analysis 

      Achten, Niek B.; Plötz, Frans B.; Klingenberg, Claus; Stocker, Martin; Bokelaar, Robin; Bijlsma, Merijn; Giannoni, Eric; van Rossum, Annemarie M.C.; Benitz, William E. (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-02-03)
      Objectives - To provide a comprehensive assessment of case stratification by the Neonatal Early-Onset Sepsis (EOS) Calculator, a novel tool for reducing unnecessary antibiotic treatment.<p> <p>Study design - A systematic review with individual patient data meta-analysis was conducted, extending PROSPERO record CRD42018116188. Cochrane, PubMed/MEDLINE, EMBASE, Web of Science, Google Scholar, and ...

    • Effects of age and gender on the relationship between alcohol use disorder and somatic diseases: a national register study in Norway 

      Abebe, Dawit Shawel; Lien, Lars; Bramness, Jørgen Gustav (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-11-10)
      Objective - This study aimed to examine how age and gender moderate the associations between alcohol use disorders (AUD) and several somatic diseases. <p> <p>Design and setting - We performed a retrospective, register-based cohort study with 6-year follow-up of patients with AUD and the general population. Data were acquired from the Norwegian Patient Registry. Cox regressions were used to estimate ...

    • A Screening for Virus Infections in Eight Herds of Semi-domesticated Eurasian Tundra Reindeer (Rangifer tarandus tarandus) in Norway, 2013–2018 

      Tryland, Morten; Sanchez Romano, Javier; Nymo, Ingebjørg Helena; Breines, Eva Marie; Murguzur, Francisco Javier Ancin; Kjenstad, Ole Christian; Li, Hong; Cunha, Cristina W. (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-10-12)
      Background: Previous serological screenings have indicated that Eurasian semi-domesticated tundra reindeer (Rangifer tarandus tarandus) in Finnmark, Northern Norway, are exposed to alphaherpesvirus, gammaherpesvirus and pestivirus. Alphaherpesvirus (i.e., Cervid herpesvirus 2; CvHV2) has been identified as the transmissible component of infectious keratoconjunctivitis (IKC). Limited knowledge exists ...

    • “Mapping suicide prevention initiatives targeting Indigenous Sámi in Nordic countries” 

      Stoor, Jon Petter A.; Eriksen, Heidi A.; Silviken, Anne (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-11-07)
      Background - Suicide is a major public health issue among Indigenous Sámi in Nordic countries, and efforts to prevent suicide in the Sámi context are increasing. However, there is no literature on suicide prevention initiatives among Sámi. The aim of the study was to map suicide prevention initiatives targeting Sámi in Norway, Sweden, and Finland during 2005–2019.<p> <p>Method - Initiatives were ...

    • Effectiveness of Natalizumab in Achieving No Evidence of Disease Activity (NEDA-3)—Data From a Local Norwegian Cohort 

      Jaklin, Andreas K.; Benjaminsen, Espen; Alstadhaug, Karl Bjørnar (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-10-20)
      Objective: We aimed to determine the effectiveness of natalizumab (NTZ) by assessing overall No Evidence of Disease Activity 3 (NEDA-3) in a local Norwegian cohort. <p> <p>Background: NTZ is an immunomodulating drug used in the treatment of multiple sclerosis (MS). It has typically been used as a second-line treatment, but certain patients with high disease activity have started directly with ...

    • Assessing a Sensory-Motor-Cognition Triad in Amnestic Mild Cognitive Impairment With Dichotic Listening While Walking: A Dual-Task Paradigm 

      Gorecka, Marta Maria; Vasylenko, Olena; Waterloo, Knut; Rodriguez-Aranda, Claudia (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-11-12)
      A contemporary topic in aging research relates to the significance of cognitive changes proper to mild cognitive impairment (MCI) to higher risk of falls and gait deteriorations. The present study addresses this question in the amnestic type of MCI (aMCI) by examining a triad of interrelated comorbidities occurring in the MCI condition: attentional impairments, hearing loss and gait disturbances. ...