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norskDet helsevitenskapelige fakultet: Recent submissions
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Quantitative analysis methods for studying fenestrations in liver sinusoidal endothelial cells. A comparative study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2021-07-28)Liver Sinusoidal Endothelial Cells (LSEC) line the hepatic vasculature providing blood filtration via transmembrane nanopores called fenestrations. These structures are 50−300 nm in diameter, which is below the resolution limit of a conventional light microscopy. To date, there is no standardized method of fenestration image analysis. With this study, we provide and compare three different approaches: ... -
Editorial Perspective: Prato Research Collaborative for change in parent and child mental health – principles and recommendations for working with children and parents living with parental mental illness
(Journal article; Tidsskriftartikkel; Peer reviewed, 2021-09-28)Children whose parents have mental illnesses are among the most vulnerable in our communities. There is however, much that can be done to prevent or mitigate the impact of a parent’s illness on children. Notwithstanding the availability of several evidence-based interventions, efforts to support these children have been limited by a lack of adequate support structures. Major service reorientation ... -
The obesity epidemic; population levels of visceral adipose tissue and trends in body composition. Insights from The Tromsø Study
(Doctoral thesis; Doktorgradsavhandling, 2021-12-09)<p><i>Background:</i> Simultaneously with the growing obesity epidemic, cardiometabolic risk have decreased in high-income countries. Do the most frequently used general and abdominal obesity measures (BMI and waist circumference) fail to represent actual obesity and obesity-related health risk? <p><i>Aims:</i> 1) present reference- and threshold values for DXA-derived visceral adipose tissue (VAT) ... -
Dietary intake of advanced glycation endproducts and risk of hepatobiliary cancers: A multinational cohort study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2021-04-25)Advanced glycation endproducts (AGEs) may contribute to liver carcinogenesis because of their proinflammatory and prooxidative properties. Diet is a major source of AGEs, but there is sparse human evidence on the role of AGEs intake in liver cancer etiology. We examined the association between dietary AGEs and the risk of hepatobiliary cancers in the European Prospective Investigation into Cancer ... -
Antimicrobial resistance acquisition via natural transformation: context is everything
(Journal article; Tidsskriftartikkel; Peer reviewed, 2021-10-26)Natural transformation is a process where bacterial cells actively take up free DNA from the environment and recombine it into their genome or reconvert it into extra-chromosomal genetic elements. Although this mechanism is known to mediate the uptake of antibiotic resistance determinants in a range of human pathogens, its importance in the spread of antimicrobial resistance is not always appreciated. ... -
The survival time of restorations is shortened in patients with dry mouth
(Journal article; Tidsskriftartikkel; Peer reviewed, 2021-09-03)Objectives - The aim of this retrospective data collection study was to determine the effect size of dry mouth on the survival of restorations and teeth.<p> <p>Methods - The data were collected from the electronic patient files of City of Oulu Public Dental Services (Finland). Study population consisted of 71 dry mouth patients and 142 control patients. The survival of 3208 restorations were ... -
Napping alone in the snow and cuddling with mommy at night: An exploratory, qualitative study of Norwegian beliefs on infant sleep
(Journal article; Tidsskriftartikkel; Peer reviewed, 2021-10-23)This study addresses Norwegian infants’ sleeping places during the day and night. In the first part we asked the general public to indicate where they think infants should sleep by placing stickers on a depiction of different sleeping places. This revealed that infants were expected to predominantly sleep outside in a stroller during the day and either bedshare, room share or sleep independently ... -
Nanomedicines for the topical treatment of vulvovaginal infections: Addressing the challenges of antimicrobial resistance
(Journal article; Tidsskriftartikkel; Peer reviewed, 2021-06-30)Recent years have, surprisingly, witnessed an increase in incidence of sexually transmitted infections (STIs). At the same time, antimicrobial therapy came under the threat of ever rising antimicrobial resistance (AMR), resulting in STIs with extremely limited therapy options. In this review, we addressed the challenges of treating vaginal infections in an era of AMR. We focused on published work ... -
Coffee and tea consumption and risk of pre- and postmenopausal breast cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2015-01-31)Introduction: Specific coffee subtypes and tea may impact risk of pre- and post-menopausal breast cancer differently. We investigated the association between coffee (total, caffeinated, decaffeinated) and tea intake and risk of breast cancer.<p> <p>Methods: A total of 335,060 women participating in the European Prospective Investigation into Nutrition and Cancer (EPIC) Study, completed a dietary ... -
Secular and longitudinal trends in body composition: The Tromsø Study, 2001 to 2016
(Journal article; Tidsskriftartikkel; Peer reviewed, 2021-09-14)<p><i>Objective - </i>Overweight, defined as excessive fat mass, is a long-standing worldwide public health challenge. Traditional anthropometric measures used to identify overweight and obesity do not assess body composition. The aim of this study was to examine population trends in general and abdominal fat mass during the past two decades. <p><i>Methods - </i>This study included participants ... -
Oral health among the indigenous Sámi population. A population-based study on periodontal health, dental caries, and oral health-related quality of life
(Doctoral thesis; Doktorgradsavhandling, 2021-12-08)<p><i>Background/Aim:</i> The lack of scientific knowledge on oral health in Sámi populations and the regional differences in caries experience among children in Northern Norway has raised the question of whether the high prevalence of oral disease in that geographic area differs by ethnicity. Evidence-based knowledge on oral health conditions in adults in these areas is scarce. The overall objective ... -
Mechanism and structural requirements for formation of p62 bodies and degradation of p62 by selective autophagy
(Doctoral thesis; Doktorgradsavhandling, 2021-12-03)Selective autophagy is responsible for the lysosomal degradation of damaged and surplus cytoplasmic components, including misfolded proteins and dysfunctional organelles. Selective autophagy is required for protein and organelle quality control basally and upon stress. For the autophagic process to be precise, selective autophagy receptors (SARs) like SQSTM1/p62 are required. Autophagic substrates ... -
Trygg kirurgi - oppdekking og organisering av instrumentbord til operasjon: en scoping review
(Journal article; Tidsskriftartikkel; Peer reviewed, 2021-04-08)Bakgrunn: Oppdekking og organisering av instrumentbord er en kompleks arbeidsprosess som krever et bredt kunnskapsgrunnlag. Når kunnskapsbaserte anbefalinger tas i bruk, øker sikkerheten i operasjonsrommet. Hensikt: Studiens hensikt var å styrke utøvernes beslutningsgrunnlag. Det gjøres ved å samle, strukturere, oppsummere og presentere kunnskapsbaserte anbefalinger. <p> <p>Metode: Vi utførte en ... -
Effects of cold decompression on hemodynamic function and DCS risk in a dry diving rat model
(Journal article; Tidsskriftartikkel; Peer reviewed, 2021-11-03)Background: Diving in cold water is thought to increase the risk of decompression sickness (DCS), especially if the diver is cold during decompression. In this study, we investigated hemodynamic function and DCS risk in an animal model, where cold decompression was followed by rewarming at the surface. <p> <p>Methods: Nine female Sprague Dawley rats had pressure-volume catheters inserted into ... -
Gastric Cancer surgery at the University Hospital of Northern Norway from 2007 to 2017, from open to minimal invasive surgery
(Master thesis; Mastergradsoppgave, 2020-11-12)Background: Gastric cancer is one of the leading causes of cancer related death, world-wide. The most common type is adenocarcinoma, which account for 95% of all gastric tube cancers. Curative treatment always includes surgery and, with few exceptions, neoadjuvant and adjuvant chemotherapy. The surgical treatment of gastric cancer has changed from open to minimally invasive surgery in many centers ... -
The temporal development of cognitive behavioral therapy as treatment for unipolar depression. An evaluation based on three meta-analyses, focusing on time-trends, effect sizes, and associated moderators
(Doctoral thesis; Doktorgradsavhandling, 2021-11-29)The present thesis` main objective was to examine time-trends related to CBT as an anti-depressive treatment. A meta-analytic approach was the tool for such investigations, in which the formats of individual, group (GCBT), and mindfulness-based cognitive behavioral therapy (MCBT) were explored from a temporal point of view, and the results subsequently summarized in four articles. The meta-analyses ... -
An App-Based Intervention for Adolescents Exposed to Cyberbullying in Norway: Protocol for a Randomized Controlled Trial
(Journal article; Tidsskriftartikkel; Peer reviewed, 2021-07-06)Background: Adolescents exposed to negative online events are at high risk to develop mental health problems. Little is known about what is effective for treatment in this group. NettOpp is a new mobile app for adolescents who have been exposed to cyberbullying or negative online experiences in Norway.<p> <p>Objective: The aim of this paper is to provide a description of the content of the ... -
Alcohol consumption, endogenous estrogen and mammographic density among premenopausal women
(Journal article; Tidsskriftartikkel; Peer reviewed, 2015-08-07)Introduction: Alcohol consumption may promote aromatization of androgens to estrogens, which may partly explain the observations linking alcohol consumption to higher breast cancer risk. Whether alcohol consumption is associated with endogenous estrogen levels, and mammographic density phenotypes in premenopausal women remains unclear.<p> <p>Methods: Alcohol consumption was collected by self-report ... -
Genetic risk variants associated with in situ breast cancer
(Journal article; Tidsskriftartikkel; Peer reviewed, 2015-06-13)Introduction: Breast cancer in situ (BCIS) diagnoses, a precursor lesion for invasive breast cancer, comprise about 20 % of all breast cancers (BC) in countries with screening programs. Family history of BC is considered one of the strongest risk factors for BCIS.<p><p>Methods: To evaluate the association of BC susceptibility loci with BCIS risk, we genotyped 39 single nucleotide polymorphisms (SNPs), ... -
Fetal cardiac function at intrauterine transfusion assessed by automated analysis of color tissue Doppler recordings
(Journal article; Tidsskriftartikkel; Peer reviewed, 2020-08-13)Background: Fetal anemia is associated with a hyperdynamic circulation and cardiac remodeling. Rapid intrauterine transfusion (IUT) of blood with high hematocrit and viscosity into the umbilical vein used to treat this condition can temporarily further affect fetal heart function. The aim of this study was to evaluate the short-term changes in fetal myocardial function caused by IUT using automated ...
