Now showing items 3761-3780 of 10441

    • Hemodynamic effects of a soluble guanylate cyclase stimulator, Riociguat, and an activator, Cinaciguat, during NO-modulation in healthy pigs 

      Næsheim, Torvind; How, Ole-Jakob; Myrmel, Truls (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-07-14)
      Cardiovascular diseases are often characterized by dysfunctional endothelium. To compensate for the related lack of nitric oxide (NO), a class of soluble guanylate cyclase (sGC) stimulators and activators have been developed with the purpose of acting downstream of NO in the NO-sGC-cGMP cascade. These drugs have been discovered using photoaffinity labeling of sGC and high-throughput screening of a ...
    • Labour outcomes with defibulation at delivery in immigrant Somali and Sudanese women with type III female genital mutilation/cutting 

      Rouzi, Abdulrahim A.; Berg, Rigmor; Al-Wassia, Heidi; Alamoudi, Rana; Hariri, Wajeh; Sindi, Ghazi; Almansouri, Nisma; Sahly, Nora (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-08-24)
      INTRODUCTION There is a scarcity of studies on labour outcomes with defibulation. This study assessed the outcomes of labour with defibulation at delivery in women with type III female genital mutilation/cutting (FGM/C) compared to labour without defibulation. METHODS We identified and reviewed the records of all Somali and Sudanese women who delivered at King Abdulaziz University Hospital, ...
    • Yersinia enterocolitica: A Follow-up of the Outbreak in the Norwegian Armed Forces in 2014 

      Borud, Einar Kristian; Håberg, Siri Eldevik; Norheim, Arne Johan; Strand, Leif Åge; Fadum, Elin Anita (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-11-28)
      Introduction - In the spring of 2014, there was an outbreak of Yersinia enterocolitica (YE) gastroenteritis in four Norwegian military camps—the largest outbreak ever reported in Norway. YE is usually transmitted via food, and the gastrointestinal disease caused by the bacterium is considered a public health problem in several countries. Common symptoms of YE gastroenteritis are abdominal pain, ...
    • Recurrent disease after treatment for cervical intraepithelial neoplasia-The importance of a flawless definition of residual disease and length of follow-up 

      Bjørnerem, Mathilde Seeger; Sørbye, Sveinung; Skjeldestad, Finn Egil (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-03-09)
      Objective - To evaluate adherence to national guidelines for follow-up, and assess residual and recurrent disease after treatment for cervical intraepithelial neoplasia grade 2 or worse (CIN2+).<p> <p>Study design - In a case-series design women aged 25–69 years treated for primary CIN2+ in 2006–2011 (n = 752) were followed through August 9, 2019 for residual or recurrent disease, i.e., CIN2+ ...
    • Effects of a parent-administered exercise program in the neonatal intensive care unit: Dose does matter-a randomized controlled trial 

      Øberg, Gunn Kristin; Girolami, Gay L; Campell, Suzann K.; Ustad, Tordis; Heuch, Ivar; Jacobsen, Bjarne K.; Kaaresen, Per Ivar; Aulie, Vibeke Smith; Jørgensen, Lone (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-04-06)
      Background - Despite the risk of delayed motor development in infants born preterm, knowledge about interventions in the neonatal intensive care unitt (NICU) and the effects of dosing is sparse. <p> <p>Objective - The objectives of this study were to examine the effectiveness of a parent-administered exercise program in the NICU on motor outcome at 3 months corrected age (CA) and the effect of ...
    • STudy of Antithrombotic Treatment after IntraCerebral Haemorrhage: Protocol for a randomised controlled trial 

      Larsen, Kristin Tveitan; Forfang, Elisabeth; Pennlert, Johanna; Glader, Eva-Lotta; Kruuse, Christina; Wester, Per; Ihle-Hansen, Hege; Carlsson, Maria; Berge, Eivind; Al-Shahi Salman, Rustam; Wyller, Torgeir Bruun; Rønning, Ole M. (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-09-03)
      Background and aims - Many patients with prior intracerebral haemorrhage have indications for antithrombotic treatment with antiplatelet or anticoagulant drugs for prevention of ischaemic events, but it is uncertain whether such treatment is beneficial after intracerebral haemorrhage. STudy of Antithrombotic Treatment after IntraCerebral Haemorrhage will assess (i) the effects of long-term antithrombotic ...
    • The Confidence Database 

      Rahnev, Dobromir; Desender, Kobe; Lee, Alan L. F.; Adler, William T.; Aguilar-Lleyda, David; Akdoğan, Başak; Arbuzova, Polina; Atlas, Lauren Y.; Balcı, Fuat; Bang, Ji Won; Bègue, Indrit; Birney, Damian P.; Brady, Timothy F.; Calder-Travis, Joshua; Chetverikov, Andrey; Clark, Torin K.; Davranche, Karen; Denison, Rachel N.; Dildine, Troy C.; Double, Kit S.; Duyan, Yalçın A.; Faivre, Nathan; Fallow, Kaitlyn; Filevich, Elisa; Gajdos, Thibault; Gallagher, Regan M.; de Gardelle, Vincent; Gherman, Sabina; Haddara, Nadia; Hainguerlot, Marine; Hsu, Tzu-Yu; Hu, Xiao; Iturrate, Iñaki; Jaquiery, Matt; Kantner, Justin; Koculak, Marcin; Konishi, Mahiko; Koß, Christina; Kvam, Peter D.; Kwok, Sze Chai; Lebreton, Maël P.; Lempert, Karolina M.; Ming Lo, Chien; Luo, Liang; Maniscalco, Brian; Martin, Antonio; Massoni, Sébastien; Matthews, Julian; Mazancieux, Audrey; Merfeld, Daniel M.; O’Hora, Denis; Palser, Eleanor R.; Paulewicz, Borysław; Pereira, Michael; Peters, Caroline; Philiastides, Marios G.; Pfuhl, Gerit; Prieto, Fernanda; Rausch, Manuel; Recht, Samuel; Reyes, Gabriel; Rouault, Marion; Sackur, Jérôme; Sadeghi, Saeedeh; Samaha, Jason; Seow, Tricia X. F.; Shekhar, Medha; Sherman, Maxine T.; Siedlecka, Marta; Skóra, Zuzanna; Song, Chen; Soto, David; Sun, Sai; van Boxtel, Jeroen J. A.; Wang, Shuo; Weidemann, Christoph T.; Weindel, Gabriel; Wierzchoń, Michał; Xu, Xinming; Ye, Qun; Yeon, Jiwon; Zou, Futing; Zylberberg, Ariel (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-02-03)
      Understanding how people rate their confidence is critical for the characterization of a wide range of perceptual, memory, motor and cognitive processes. To enable the continued exploration of these processes, we created a large database of confidence studies spanning a broad set of paradigms, participant populations and fields of study. The data from each study are structured in a common, easy-to-use ...
    • Intestinal inflammatory profile shows increase in a diversity of biomarkers in irritable bowel syndrome 

      Berg, Leif Kyrre; Goll, Rasmus; Fagerli, Erik; Ludviksen, Judith K; Fure, Hilde; Odd Sverre, Moen; Sørbye, Sveinung; Mollnes, Tom Eirik; Florholmen, Jon (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-04-24)
      Background: It has been proposed that irritable bowel syndrome (IBS) is a low-grade mucosal inflammatory disease. <p> <p>Objective: To characterize the intestinal inflammatory profile in IBS patients with or without fructose intolerance.<p> <p>Design: Patients referred to colonoscopy with IBS complaints were screened for participation. IBS patients diagnosed according to the Rome II criteria ...
    • Tracking of serum 25-hydroxyvitamin D during 21 years 

      Kubiak, Julia Magdalena; Kamycheva, Elena; Jorde, Rolf (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-12-11)
      Background/objectives - Our objective was to evaluate the degree of tracking for serum levels of 25-hydroxyvitamin D [25(OH)D] over time, by using data from three previously conducted surveys of the Tromsø study collected in the years 1994/1995 (Tromsø 4), 2007/2008 (Tromsø 6), and 2015/2016 (Tromsø 7).<p> <p>Subjects/methods - Subjects with valid 25(OH)D measurements in all three surveys were ...
    • Provider decision regret - a useful method for analysis of palliative thoracic re-irradiation for lung cancer? 

      Nieder, Carsten; Mannsåker, Bård; Yobuta, Rosalba; Haukland, Ellinor Christin (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-01-30)
      Background - The overall usefulness of palliative thoracic re-irradiation depends on the balance between efficacy, survival, and toxicity, and is difficult to judge from previous studies. In the absence of patient-reported data, we developed a method for provider decision regret that addresses the question “would we re-irradiate this patient again in light of the known outcome?” Furthermore, we ...
    • Symptom burden in patients with oligometastases at the start of palliative radiotherapy 

      Nieder, Carsten; Kämpe, Thomas A (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-03-04)
      Background/Aim: Recent studies suggested that patients with oligometastases have a better prognosis compared with those who have widespread dissemination. In both groups, radiotherapy is a commonly applied treatment. Patient-reported symptoms might depend on the burden of disease. Possibly, oligometastatic patients report lower scores for symptoms, such as fatigue or reduced appetite, which tend to ...
    • Long-term survival results after treatment for oligometastatic brain disease 

      Nieder, Carsten; Hintz, Mandy; Popp, Ilinca; Bilger, Angelika; Grosu, Anca L. (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-03-04)
      Aim - The aim of this study was to characterize the survival results of patients with up to four brain metastases after intense local therapy (primary surgery or stereotactic radiotherapy) if extracranial metastases were absent or limited to one site, e.g. the lungs.<p> <p>Background - Oligometastatic disease has repeatedly been reported to convey a favorable prognosis.<p> <p>Material and ...
    • Direct angiography demonstrates equal 8-12 years patency rates of radial artery and saphenous vein grafts 

      Bahar, Ramez; Dahl-Eriksen, Øystein; Busund, Rolf; Dahl, Per Erling; Hermansen, Stig Eggen; Iqbal, Amjid; Mannsverk, Jan; Myrmel, Truls; Steigen, Terje; Trovik, Thor; Sørlie, Dag Glen; Bartnes, Kristian (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-06-30)
      Objectives: The benefits of coronary artery bypass surgery depend on lasting graft patency. To aid rational graft selection, the relative long-term merits of radial artery and saphenous vein grafts need to be determined by a gold standard method and with minimal clinically driven selection bias. Methods: The patency rates of various conduits were determined by direct angiography in 76 patients from ...
    • No significant histological or ultrastructural tendinosis changes in the hamstring tendon in patients with mild to moderate osteoarthritis of the knee? 

      Ibrahim, Mustafa; Meknas, Khaled; Steigen, Sonja Eriksson; Olsen, Randi; Sernert, Ninni; Ejerhed, Lars ERik; Kartus, Jüri-Tomas (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-06-05)
      Purpose - To investigate the periarticular degenerative changes of the knee joint in association with osteoarthritis (OA). More tendinosis was expected to be found in the semitendinosus tendon in patients with knee OA than in patients without knee OA.<p> <p>Methods - Samples from 41 patients were included between January 2016 and October 2017. Twenty-one patients median age 53 (33–63) years with ...
    • Atrial fibrillation, venous thromboembolism, ischemic stroke, and all-cause mortality: The Tromsø study 

      Hald, Erin Mathiesen; Løchen, Maja-Lisa; Mathiesen, Ellisiv B; Wilsgaard, Tom; Njølstad, Inger; Brækkan, Sigrid K.; Hansen, John-Bjarne (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-07-06)
      Background Atrial fibrillation (AF) is associated with increased risk of ischemic stroke and all‐cause mortality. Patients with AF are also at increased risk of venous thromboembolism (VTE), but information on how AF impacts VTE‐related mortality is scarce. Objectives - To investigate the impact of AF on all‐cause mortality in subjects with and without a thromboembolic event (VTE or ischemic ...
    • D-dimer as a stand-alone test to rule out deep vein thrombosis 

      Rinde, Fridtjof Balteskard; Frønæs, Synne Grønvold; Ghanima, Waleed Khalid; Vik, Anders; Hansen, John-Bjarne; Brækkan, Sigrid (Journal article; Tidsskriftartikkel, 2020-04-25)
      Background - Current guidelines recommend the use of clinical decision rules, such as Wells score, in combination with D-dimer to assess the need for objective imaging to rule out deep vein thrombosis (DVT). However, the clinical decision rule has limitations, and use of D-dimer as a stand-alone test has been suggested.<p> <p>Objective - We aimed to assess the safety and efficiency of D-dimer as ...
    • Nutritional status, sarcopenia, gastrointestinal symptoms and quality of life after gastrectomy for cancer - A cross-sectional pilot study 

      Gharagozlian, Sedegheh; Mala, Tom; Brekke, Hilde Kristin; Kolbjørnsen, Lisa; Ullerud, Åslaug; Johnson, Egil (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-03-06)
      <i>Background and aims</i> - Gastrointestinal (GI) symptoms, malabsorption, reduced food intake and weight loss are common sequela of gastrectomy. This can result in malnutrition with a subsequent prolonged recovery, reduced physical functioning and deteriorated quality of life (QoL). Few studies have investigated the relationship between GI-symptoms, QoL and malnutrition in long-term survivors of ...
    • The fraction of lung cancer attributable to smoking in the Norwegian Women and Cancer (NOWAC) Study 

      Hansen, Merethe Selnes; Licaj, Idlir; Braaten, Tonje; Lund, Eiliv; Gram, Inger Torhild (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-10-27)
      <i>Background</i> - We examined the association between active and passive smoking and lung cancer risk and the population attributable fraction (PAF) of lung cancer due to active smoking, in the Norwegian Women and Cancer Study, a nationally representative prospective cohort study.<br><br> <i>Methods</i> - We followed 142,508 women, aged 31–70 years, who completed a baseline questionnaire between ...
    • Leisure physical exercise and creatine kinase activity. The Tromsø study 

      Bekkelund, Svein Ivar (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-08-16)
      Creatine kinase (CK) is an enzyme catalyzing energy reaction in muscle cells and has proven to modify cardiovascular risks. The influence of skeletal muscle activity on CK concentrations is a potential study confounder but is mainly reported in connection with sport activities. This study investigated the association between leisure physical exercise and CK and estimated the effect of physical ...
    • Acquiring sub-efficient and efficient variants of novel means by integrating information from multiple social models in preschoolers 

      Altınok, Nazlı; Hernik, Mikołaj; Király, Ildikó; Gergely, György (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-04-08)
      Sub-efficient action routines often represent culture-specific conventional forms of actions that belong to the repertoire of cultural knowledge shared by a social group. Children readily acquire such sub-efficient routines from social demonstrations and often preserve them in their action repertoire despite encountering more efficient alternatives. This suggests that they can treat sub-efficient ...