Background: Atrophy of the medial temporal lobe (MTL) is a biological characteristic of Alzheimer’s disease (AD) and can be measured by segmentation of magnetic resonance images (MRI). Objective: To assess the clinical utility of automated volumetry in a cognitively well-defined and biomarker-classified multi-center longitudinal predementia cohort. <p>Methods: We used Automatic Segmentation of ...

Background In advanced clinical learning labs on campus, high-fidelity simulation has become an essential educational approach in the Bachelor of Nursing Education programme. However, simulation while in clinical placement, in situ, is rarely used in Bachelor of Nursing Education. The aim of the present study was to explore how in situ simulation training at a surgical hospital ward, according ...

Membrane transporter proteins are divided into channels/pores and carriers and constitute protein families of physiological and pharmacological importance. Several presently used therapeutic compounds elucidate their effects by targeting membrane transporter proteins, including anti-arrhythmic, anesthetic, antidepressant, anxiolytic and diuretic drugs. The lack of three-dimensional structures of ...

Introduction - It is important to understand the factors impacting the quality of services provided through community pharmacies. Exploring how key stakeholders perceive good quality in these services is a logical first step. This could also inform the development of quality measures, such as quality indicators (QIs).<p> <p>Aim - To identify key stakeholders' perspectives on the quality of services ...

Performance characteristics of mammography readers influenced the performance of pairs, but specific pairing strategies did not result in significantly different overall performance compared with that resulting from random pairing strategies.<p> <p>Background - Despite variation in performance characteristics among radiologists, the pairing of radiologists for the double reading of screening ...

Irregular attendance in breast cancer screening has been associated with higher breast cancer mortality compared to regular attendance. Early performance measures of a screening program following regular versus irregular screening attendance have been less studied. We aimed to investigate early performance measures following regular versus irregular screening attendance. Methods We used information ...

In their lead article, Klug et al. conceptualize job insecurity as a multilevel construct whereby individuals are situated in meso- and macro-level contexts. Their resulting model highlights that the experience of job insecurity, as well as reactions to job insecurity, are not only affected by factors emanating from individuals' direct environment (i.e., at the individual level) but also from different ...

Background: Many studies have shown that socioeconomic position (SEP) is associated with the incidence of malignant tumors at different sites. This study aims to estimate the association between educational level (as proxy for SEP) and cancer incidence and to understand whether the observed associations might be partially explained by lifestyle behaviors.<p> <p>Methods: The analyses were performed ...

More than 38% of both screen-detected and interval cancers were assigned the highest artificial intelligence risk score on screening mammograms that preceded breast cancer diagnosis.<p> <p>Background - Few studies have evaluated the role of artificial intelligence (AI) in prior screening mammography.<p> <p>Purpose - To examine AI risk scores assigned to screening mammography in women who were ...

The bacterial magnesium transporter A (MgtA) is a specialized P-type ATPase important for Mg²⁺ import into the cytoplasm; disrupted magnesium homeostasis is linked to intrinsic ribosome instability and antibacterial resistance in Salmonella strains. Here, we show that MgtA has functional specificity for cardiolipin 18:1. Still, it reaches maximum activity only in combination with ...