Det helsevitenskapelige fakultet: Recent submissions
Now showing items 461-480 of 10396
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Data driven or data informed? How general practitioners use data to evaluate their own and colleagues’ clinical work in clusters
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-12-29)In contemporary policy discourses, data are presented as key assets for improving health-care quality: policymakers want health care to become ‘data driven’. In this article, we focus on a particular example of this ambition, namely a new Danish national quality development program for general practitioners (GPs) where doctors are placed in so-called ‘clusters’. In these clusters, GPs are obliged ... -
Breast cancer missed at screening; hindsight or mistakes?
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-06-03)Purpose - To investigate radiologists’ interpretation scores of screening mammograms prior to diagnosis of screen-detected and interval breast cancers retrospectively classified as missed or true negative.<p> <p>Methods - We included data on radiologists’ interpretation scores at screening prior to diagnosis for 1223 screen-detected and 1007 interval cancer cases classified as missed or true ... -
Does it make sense to use written instruments to assess communication skills? Systematic review on the concurrent and predictive value of written assessment for performance
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-12-23)Objectives - To evaluate possible associations between learners’ results in written and performance-based assessments of communication skills (CS), either in concurrent or predictive study designs.<p> <p>Methods - Search included four databases for peer-reviewed studies containing both written and performance-based CS assessment. Eleven studies met the inclusion criteria.<p> <p>Results - ... -
Berøringens potensial i barnefysioterapi
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023)Artikkelen utforsker og beskriver berøringens betydning og potensial i fysioterapi til barn som er født for tidlig. Gjennom å forstå berøring som et intersubjektivt kroppslig fenomen sentralt for barns utvikling og forståelse av seg selv og sine omgivelser, beskriver artikkelen hvordan berøring er del av bevegelse, persepsjon og handling og alltid inngår i terapiprosesser. Berøring fremstår i denne ... -
Incidence of venous thromboembolism, recurrence, and bleeding after isolated superficial vein thrombosis: findings from the Venous Thrombosis Registry in Østfold Hospital
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-10-31)Background - There are limited data on the long-term risk of venous thromboembolism (VTE) after high-risk isolated superficial vein thrombosis (iSVT) treated with anticoagulants.<p> <p>Objectives - To determine the short- and long-term risk of VTE and iSVT recurrence after cessation of anticoagulant treatment and to calculate 45-day cumulative bleeding incidence in patients with iSVT.<p> <p>Methods ... -
Echoes from Intrinsic Connectivity Networks in the Subcortex
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-09-27)Decades of research have greatly improved our understanding of intrinsic human brain organization in terms of functional networks and the transmodal hubs within the cortex at which they converge. However, substrates of multinetwork integration in the human subcortex are relatively uncharted. Here, we leveraged recent advances in subcortical atlasing and ultra-high field (7 T) imaging optimized for ... -
Combined effect of high factor VIII levels and high mean platelet volume on the risk of future incident venous thromboembolism
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-06-29)Background - High factor VIII (FVIII) levels and large platelets, as reflected by a high mean platelet volume (MPV), are separately associated with increased risk of venous thromboembolism (VTE). Whether the combination of high FVIII levels and large platelets has a supra-additive effect on VTE risk is unknown.<p> <p>Objectives - We aimed to investigate the joint effect of high FVIII levels and ... -
The Risk of Incident Venous Thromboembolism Attributed to Overweight and Obesity: The Tromso Study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-08-07)Background: Obesity is a well-established risk factor for venous thromboembolism (VTE). However, data on the proportion of incident VTEs attributed to overweight and obesity in the general population are limited.<p> <p>Objective: To investigate the population attributable fraction (PAF) of VTE due to overweight and obesity in a population-based cohort with repeated measurements of body mass index ... -
Brain Metastases: Is There Still a Role for Whole-Brain Radiation Therapy?
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-03-27)Whole-brain radiation therapy (WBRT) has commonly been prescribed to palliate symptoms from brain metastases, to reduce the risk of local relapse after surgical resection, and to improve distant brain control after resection or radiosurgery. While targeting micrometastases throughout the brain can be considered advantageous, the simultaneous exposure of healthy brain tissue might cause adverse events. ... -
Flexible and Biocompatible Antifouling Polyurethane Surfaces Incorporating Tethered Antimicrobial Peptides through Click Reactions
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-11-27)Efficient, simple antibacterial materials to combat implant-associated infections are much in demand. Herein, the development of polyurethanes, both cross-linked thermoset and flexible and versatile thermoplastic, suitable for “click on demand” attachment of antibacterial compounds enabled via incorporation of an alkyne-containing diol monomer in the polymer backbone, is described. By employing ... -
Recognition of COVID-19 with occupational origin: a comparison between European countries
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-11-20)Objectives -This study aims to present an overview of the formal recognition of COVID-19 as occupational disease (OD) or injury (OI) across Europe.<p> <p>Methods - A COVID-19 questionnaire was designed by a task group within COST-funded OMEGA-NET and sent to occupational health experts of 37 countries in WHO European region, with a last update in April 2022.<p> <p>Results - The questionnaire ... -
Pårørendes erfaringer fra samarbeid med helsepersonell på skjermet enhet for personer med demens.
(Journal article; Tidsskriftartikkel, 2023)I de senere årene har det vært sterkt fokus på pårørendes rolle i ivaretakelsen av eldres helseutfordringer, og pårørendesamarbeid er viet stor plass i nasjonale og politiske føringer. -
Global Transcriptome Analysis Reveals Distinct Phases of the Endothelial Response to TNF
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-11-29)The vascular endothelium acts as a dynamic interface between blood and tissue. TNF-α, a major regulator of inflammation, induces endothelial cell (EC) transcriptional changes, the overall response dynamics of which have not been fully elucidated. In the present study, we conducted an extended time-course analysis of the human EC response to TNF, from 30 min to 72 h. We identified regulated genes and ... -
Increased expression of individual genes in whole blood is associated with late-stage lung cancer at and close to diagnosis
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-11-25)Lung cancer (LC) mortality rates are still increasing globally. As survival is linked to stage, there is a need to identify markers for earlier LC diagnosis and individualized treatment. The whole blood transcriptome of LC patients represents a source of potential LC biomarkers. We compared expression of > 60,000 genes in whole blood specimens taken from LC cases at diagnosis (n = 128) and controls ... -
Phosphorylation of Human Polyomavirus Large and Small T Antigens: An Ignored Research Field
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-11-09)Protein phosphorylation and dephosphorylation are the most common post-translational modifications mediated by protein kinases and protein phosphatases, respectively. These reversible processes can modulate the function of the target protein, such as its activity, subcellular localization, stability, and interaction with other proteins. Phosphorylation of viral proteins plays an important role in ... -
The elusive concept of sexual motivation: can it be anchored in the nervous system?
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-11-17)Sexual motivation is an abstract concept referring to the mechanisms determining the responsivity to sexually relevant stimuli. This responsivity determines the likelihood of producing a sexual response and the intensity of that response. Both responsivity to stimuli and the likelihood of making a response as well as the intensity of response are characteristics of an individual. Therefore, we need ... -
Dying at “home” - a qualitative study of end-of-life care in rural Northern Norway from the perspective of health care professionals
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-12-05)Background - ‘Most patients want to die at home’ is a familiar statement in palliative care. The rate of home deaths is therefore often used as a success criterion. However, providing palliative care and enabling patients to die at home in rural and remote areas may be challenging due to limited health care resources and geographical factors. In this study we explored health care professionals’ ... -
Balancing on life's ladder: A meta-ethnography of the existential experiences of siblings of children with complex care needs
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-12-07)Aim - To synthesize and interpret existing qualitative research on the existential experiences of siblings of children with complex care needs.<p> <p>Design - Noblit and Hare's interpretive meta-ethnography.<p> <p>Methods - The study has been registered in the international prospective register for systematic reviews (PROSPERO). Noblit and Hare's 7-step procedure was followed and reciprocal ... -
Primærhelseteam – en mer teambasert fastlegetjeneste
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-11-29)Primærhelseteam (PHT) er en ny arbeidsform i fastlegetjenesten der lege, sykepleier og helsesekretær jobber sammen i team. Teamet skal tilby gode tjenester og arbeide systematisk med pasientsikkerhet og kvalitetsforbedring. Målgruppene for primærhelseteam er listeinnbyggere med kronisk sykdom, psykiske lidelser og rusavhengighet, skrøpelige eldre, og brukere med utviklingshemming og funksjonsnedsettelser. ... -
Effekter, gevinster og kostnader ved digital hjemmeoppfølging–en samfunnsøkonomisk analyse basert på et pragmatisk randomisert forsøk
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-11-29)Denne studien omhandler en utprøving av digital hjemmeoppfølging i helsetjenesten og omfatter seks lokale prosjekter i kommunene Stad, Bodø, Larvik, Oslo (med bydelene Sagene, Grünerløkka, Gamle Oslo og St. Hanshaugen), Ullensaker (i samarbeid med Gjerdrum) og Kristiansand (i samarbeid med flere Agder-kommuner). Utprøvingen ble gjennomført som en pragmatisk randomisert kontrollert studie. Målgruppen ...