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Association between classes and subclasses of polyphenol intake and 5-year body weight changes in the EPIC-PANACEA study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-01-24)Objective - The aim of this study was to evaluate the associations among the intake of total polyphenols, polyphenol classes, and polyphenol subclasses and body weight change over 5 years.<p> <p>Methods - A total of 349,165 men and women aged 25 to 70 years were recruited in the Physical Activity, Nutrition, Alcohol, Cessation of Smoking, Eating Out of Home and Obesity (PANACEA) project of the ... -
Prevalence and risk factors for self-reported asthma among sámi in Sweden: a cross-sectional study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-02-06)Objective - Literature about asthma among Indigenous communities worldwide is scarce. This study aimed to estimate the prevalence of self-reported asthma and to identify the risk factors associated with it among the Sámi population in Sweden.<p> <p>Methods - A population-based health study (SámiHET) was conducted among the Sámi population aged 18–84 years in 2021. The asthma outcome was self-reported. ... -
Factors associated with health-related quality of life in people living with HIV in Norway
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-02-15)Background - Despite the advances in the treatment of HIV, people living with HIV (PLHIV) still experience impairment of health-related quality of life (HRQOL). The aim of the study was to explore factors associated with HRQOL in a well-treated Norwegian HIV population.<p> <p>Methods - Two hundred and forty-five patients were recruited from two outpatient clinics to participate in this cross-sectional ... -
Defining and Scoping Participatory Health Informatics - An eDelphi Study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-03-14)Background - Health care has evolved to support the involvement of individuals in decision making by, for example, using mobile apps and wearables that may help empower people to actively participate in their treatment and health monitoring. While the term “participatory health informatics” (PHI) has emerged in literature to describe these activities, along with the use of social media for health ... -
Behandling av motoriske symptomer ved Parkinsons sykdom
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-05-04)Gjennom de siste årene har nye terapimuligheter og økt kunnskap om gamle metoder ført til endringer i vår behandling av Parkinsons sykdom. Likevel åpner alle tilgjengelige norske og utenlandske terapianbefalinger for ulike og ofte sidestilte alternativer. Basert på de evidensbaserte terapianbefalingene og på våre egne personlige erfaringer og oppfatninger presenterer vi i denne kliniske oversikten ... -
May Women with a Negative Co-Test at First Follow-Up Visit Return to 3-Year Screening after Treatment for Cervical Intraepithelial Neoplasia?
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-03-08)Background: The Norwegian Cervical Cancer Screening Programme recommends that women treated for cervical intraepithelial neoplasia (CIN) only be returned to 3-year screening after receiving two consecutive negative co-tests, 6 months apart. Here we evaluate adherence to these guidelines and assessed the residual disease, using CIN3+ as the outcome. Methods: This cross-sectional study comprised ... -
Characteristics of Patients Who Complete Suicide and Suicide Attempts While Undergoing Treatment in Norway: Findings from Compensation Claims Records
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-02-24)The aim of this study was to identify characteristics that differentiate patients who complete suicide (SC) from patients with suicide attempts (SA) while undergoing treatment in Norway. We examined data from the Norwegian System of Patient Injury Compensation (Norsk Pasientskade Erstatning—NPE). Data were extracted from NPE case records from a 10-year period (2009–2019) for 356 individuals who ... -
Bulimia symptoms and anger and aggression among adolescents
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-05-05)Background Previous research has indicated that anger and aggression may be elevated in adolescents with a bulimia nervosa (BN) diagnosis. However, as yet, little is known about whether bulimia symptoms are linked to anger and aggression in adolescents in the general population. To address this deficit this study aimed to explore the associations between a clinical level of bulimia symptoms (CLBS) ... -
Energy expenditure, dietary intake and energy availability in female professional football players
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-02-24)Objectives: To quantify energy expenditure and intake in professional female footballers playing on a national and/or international level. Second, to determine the prevalence of low energy availability among these players, defined as <30 kcal/kg fat-free mass (FFM)/day. Methods: Fifty-one players completed a 14-day prospective observational study during the 2021/2022 football season. Energy ... -
17β-estradiol promotes extracellular vesicle release and selective miRNA loading in ERα-positive breast cancer
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-05-30)The causes and consequences of abnormal biogenesis of extracellular vesicles (EVs) are not yet well understood in malignancies, including in breast cancers (BCs). Given the hormonal signaling dependence of estrogen receptor–positive (ER+) BC, we hypothesized that 17β-estradiol (estrogen) might influence EV production and microRNA (miRNA) loading. We report that physiological doses of 17β-estradiol ... -
Postoperative Dural Sac Cross-Sectional Area as an Association for Outcome After Surgery for Lumbar Spinal Stenosis: Clinical and Radiological Results From the NORDSTEN-Spinal Stenosis Trial
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-05-15)Objective - The aim was to investigate the association between postoperative dural sac cross-sectional area (DSCA) after decompressive surgery for lumbar spinal stenosis and clinical outcome. Furthermore, to investigate if there is a minimum threshold for how extensive a posterior decompression needs to be to achieve a satisfactory clinical result.<p> <p>Summary of Background Data - There is ... -
Nevus Count, Pigmentary Characteristics, and Melanoma-specific Mortality among Norwegian Women with Melanoma >1.0 mm Thick
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-04-04)Little is known about if and how nevi and pigmentation are associated with melanoma-specific mortality. However, increased melanoma awareness in people with lighter pigmentation and many nevi may result in earlier diagnosis of thinner less-lethal tumors. The aim of this study was to investigate associations between nevus count (asymmetrical > 5 mm and small symmetrical), pigmentary characteristics ... -
The classification of freezing cold injuries - a NATO research task group position paper
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-04-21)Introduction: Freezing cold injuries (FCI) are a common risk in extreme cold weather operations. Although the risks have long been recognised, injury occurrences tend to be sparse and geographically distributed, with relatively few cases to study in a systematic way. The first challenge to improve FCI medical management is to develop a common nomenclature for FCI classification. This is critical for ... -
Association between Variants in the OCA2-HERC2 Region and Blue Eye Colour in HERC2 rs12913832 AA and AG Individuals
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-03-11)The OCA2-HERC2 region is strongly associated with human pigmentation, especially eye colour. The HERC2 SNP rs12913832 is currently the best-known predictor for blue and brown eye colour. However, in a previous study we found that 43 of 166 Norwegians with the brown eye colour genotype rs12913832:AA or AG, did not have the expected brown eye colour. In this study, we carried out massively parallel ... -
Patient perceptions and experiences with medication-related activities in the emergency department: a qualitative study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-05-22)Background - Emergency department (ED) pharmacists reduce medication errors and improve quality of medication use. Patient perceptions and experiences with ED pharmacists have not been studied. The aim of this study was to explore patients’ perceptions of and experiences with medication-related activities in the ED, with and without an ED pharmacist present.<p> <p>Methods - We conducted 24 ... -
Development of early life gut resistome and mobilome across gestational ages and microbiota-modifying treatments
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-05-13)Background - Gestational age (GA) and associated level of gastrointestinal tract maturation are major factors driving the initial gut microbiota composition in preterm infants. Besides, compared to term infants, premature infants often receive antibiotics to treat infections and probiotics to restore optimal gut microbiota. How GA, antibiotics, and probiotics modulate the microbiota’s core ... -
A combined experimental-computational approach uncovers a role for the Golgi matrix protein Giantin in breast cancer progression
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-04-17)Our understanding of how speed and persistence of cell migration affects the growth rate and size of tumors remains incomplete. To address this, we developed a mathematical model wherein cells migrate in two-dimensional space, divide, die or intravasate into the vasculature. Exploring a wide range of speed and persistence combinations, we find that tumor growth positively correlates with increasing ... -
Hsa-miR-323a-3p functions as a tumor suppressor and targets STAT3 in neuroblastoma cells
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-03-24)Background: Studies conducted in the last decades have revealed a role for the non-coding microRNAs (miRNAs) in cancer development and progression. Several miRNAs within the chromosome region 14q32, a region commonly deleted in cancers, are associated with poor clinical outcome in the childhood cancer neuroblastoma. We have previously identified miR-323a-3p from this region to be downregulated in ... -
Recent advances in the roles of exosomal microRNAs in neuroblastoma
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-01-10)Exosomal miRNAs (exo-miRs), universally found in biofluids, tissues, and/or conditioned medium of the cell cultures play a significant role in cell - cell communication, thus driving cancer progression and metastasis. Very few studies have explored the role of exo-miRs in the progression of children’s cancer - neuroblastoma. In this mini review, I briefly summarize the existing literature on the ... -
Metastasis in neuroblastoma: the MYCN question
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-05-18)Oncogenic drivers like MYCN in neuroblastoma subsets continues to present a significant challenge owing to its strong correlation with high-risk metastatic disease and poor prognosis. However, only a limited number of MYCN-regulatory proteins associated with tumor initiation and progression have been elucidated. In this minireview, I summarize the recent progress in understanding the functional role ...