Det helsevitenskapelige fakultet: Nye registreringer
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Dietary patterns related to biological mechanisms and survival after breast cancer diagnosis: results from a cohort study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-02-03)Background - Inflammatory, insulin and oestrogenic pathways have been linked to breast cancer (BC). We aimed to examine the relationship between pre-diagnostic dietary patterns related to these mechanisms and BC survival.<p> <p>Methods - The diabetes risk reduction diet (DRRD), inflammatory score of diet (ISD) and oestrogen-related dietary pattern (ERDP) were calculated using dietary data from ... -
The long-term psychosocial consequences of screen-detected ductal carcinoma in situ and invasive breast cancer
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-06-07)Objective - Ductal carcinoma in situ (DCIS) is a risk factor for invasive breast cancer (IBC). The prognosis of DCIS is considerably better than for IBC, yet women do not distinguish between the threat. We aimed to compare the psychosocial consequences of screen-detected DCIS and IBC, and to examine this comparison over time.<p> <p>Methods - We surveyed a Danish mammography-screening cohort from ... -
Obesity Is Associated with Distorted Proteoglycan Expression in Adipose Tissue
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-04-07)Proteoglycans are central components of the extracellular matrix (ECM) and binding partners for inflammatory chemokines. Morphological differences in the ECM and increased inflammation are prominent features of the white adipose tissues in patients with obesity. The impact of obesity and weight loss on the expression of specific proteoglycans in adipose tissue is not well known. This study aimed to ... -
Hofteleddsdysplasi hos spedbarn – screening, behandling og oppfølging
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-04-19)Hofteleddsdysplasi forkommer hos opptil 3 % av nyfødte og kan ubehandlet føre til luksert hofteledd, osteoartritt og behov for hofteprotese. Målet med studien var å kartlegge rutiner for ultralydscreening, behandling og oppfølging av hofteleddsdysplasi ved norske sykehus. -
The COVID-19 Pandemic Sparked off a Large-Scale Outbreak of Carbapenem-Resistant Acinetobacter baumannii from the Endemic Strains at an Italian Hospital
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-03-23)Acinetobacter baumannii is a nosocomial pathogen that poses a serious threat due to the rise of incidence of multidrug-resistant (MDR) strains. During the COVID-19 pandemic, MDR A. baumannii clones have caused several outbreaks worldwide. Here, we describe a detailed investigation of an MDR A. baumannii outbreak that occurred at Policlinico San Matteo (Pavia, Italy). A total of 96 A. baumannii ... -
Red yeast rice preparations for dyslipidemia: An overview of systematic reviews and network meta-analysis
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-03-22)This research was to summarize the comparative efficacy and safety of red yeast rice (RYR) preparations and analyze the treatment ranking of lipid-lowering agents including RYR. Thirty-one systematic reviews (SRs) involving 165 randomized trials with 14,987 dyslipidemia participants were included. All the SRs showed a high overall risk of bias. A Bayesian network meta-analysis was performed. Only ... -
Deep Learning Denoising Improves and Homogenizes Patient [18F]FDG PET Image Quality in Digital PET/CT
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-05-04)Given the constant pressure to increase patient throughput while respecting radiation protection, global body PET image quality (IQ) is not satisfactory in all patients. We first studied the association between IQ and other variables, in particular body habitus, on a digital PET/CT. Second, to improve and homogenize IQ, we evaluated a deep learning PET denoising solution (Subtle PET<sup>TM</sup>) ... -
High Expression of IRS-1, RUNX3 and SMAD4 Are Positive Prognostic Factors in Stage I–III Colon Cancer
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-02-24)Colon cancer is a common malignancy and a major contributor to human morbidity and mortality. In this study, we explore the expression and prognostic impact of IRS-1, IRS-2, RUNx3, and SMAD4 in colon cancer. Furthermore, we elucidate their correlations with miRs 126, 17-5p, and 20a-5p, which are identified as potential regulators of these proteins. Tumor tissue from 452 patients operated for stage ... -
Spinal Anaesthesia as an Adjunct to General Anaesthesia for Laparoscopic Abdominoperineal Rectal Amputation
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-05-31)Background: Spinal anaesthesia as an adjunct to general anaesthesia may reduce postoperative pain and opioid consumption after laparoscopic abdominoperineal rectal amputation. We designed a randomized double blinded pilot study with two objectives: 1) to explore potential benefits of spinal anaesthesia as an adjunct to general anaesthesia and 2) to provide power and sample size estimations for ... -
Prevalence and factors associated with healthcare avoidance during the COVID-19 pandemic among the Sámi in Sweden: the SámiHET study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-05-22)The aim of this population-based cross-sectional study was to assess the prevalence of healthcare avoidance during the COVID-19 pandemic and its associated factors among the Sámi population in Sweden. Data from the “Sámi Health on Equal Terms” (SámiHET) survey conducted in 2021 were used. Overall, 3,658 individuals constituted the analytical sample. Analysis was framed using the social determinants ... -
The association of religious factors with mental health-service utilisation and satisfaction in a mixed Sámi and Norwegian adult population: Adopting the SAMINOR 2 Questionnaire Survey
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-06-18)The Indigenous Sámi have poorer mental health than the majority population and fairly equal access to professional mental healthcare. Despite this condition, certain studies indicate that this group is underrepresented among the users of such services. Religion or spirituality (R/S) often influences mental health-service utilisation and satisfaction among other Indigenous peoples and ethnic minorities. ... -
Clinical-Grade Patches as a Medium for Enrichment of Sweat-Extracellular Vesicles and Facilitating Their Metabolic Analysis
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-04-19)Cell-secreted extracellular vesicles (EVs), carrying components such as RNA, DNA, proteins, and metabolites, serve as candidates for developing non-invasive solutions for monitoring health and disease, owing to their capacity to cross various biological barriers and to become integrated into human sweat. However, the evidence for sweat-associated EVs providing clinically relevant information to use ... -
Socio-Demographic, Lifestyle, and Cardiometabolic Characteristics Associated with Low-Grade Systemic Inflammation in Russian Adult Population
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-05-14)Mortality from cardiovascular diseases (CVDs) is higher in Russia compared to other European countries. High-sensitivity C-reactive protein (hs-CRP) is a biomarker of inflammation, and its elevated levels indicate increased CVD risks. We aim to describe the prevalence of low-grade systemic inflammation (LGSI) and the associated factors in a Russian population. The Know Your Heart cross-sectional ... -
Cancer detection for white urban Americans
(Conference object; Konferansebidrag, 2023-06)Development, validation and comparison of machine learning methods require access to data, sometimes lots of data. Within health applications, data sharing can be restricted due to patient privacy, and the few publicly available data sets become even more valuable for the machine learning community. One such type of data are H&E whole slide images (WSI), which are stained tumour tissue, used in ... -
Potato Ethics: What Rural Communities Can Teach Us about Healthcare
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-04-12)In this paper I ofer the term “potato ethics” to describe a particular professional rural health sensibility. I contrast this attitude with the sensibility behind urban professional ethics, which often focus on the narrow doctor–patient treatment relationship. The phrase appropriates a Swedish metaphor, the image of the potato as a humble side dish: plain, useful, versatile, and compatible with ... -
Rusutløst psykose – en problematisk diagnose
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-02-20)Hvert år legges over 500 pasienter inn på norske sykehus med diagnosen rusutløst psykose. Men rusmiddelbruk er bare én av flere bidragende faktorer til at disse pasientene blir psykotiske, og mange får senere en schizofrenidiagnose. -
Breast cancer patient-derived explant cultures recapitulate in vivo drug responses
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-02-22)Assessment of drug sensitivity in tumor tissue ex vivo may significantly contribute to functional diagnostics to guide personalized treatment of cancer. Tumor organoid- and explant-cultures have become attractive tools towards this goal, although culturing conditions for breast cancer (BC) tissue have been among the most challenging to develop. Validation of possibilities to detect concordant responses ... -
Prevalence of undernutrition among pregnant women and its differences across relevant subgroups in rural Ethiopia: a community-based cross-sectional study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-03-10)Background - Maternal undernutrition is one of the commonest public health problems in many low- and middle-income countries where generally more than 20% of women are undernourished. It is more common in rural areas due to unclear factors. Therefore, the aim of this study was to investigate the prevalence of undernutrition in general and in subgroups and determine risk factors among pregnant women ... -
E. Sverre og medarbeidere svarer
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-02-20) -
Circulating amino acid levels and colorectal cancer risk in the European Prospective Investigation into Cancer and Nutrition and UK Biobank cohorts
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-02-28)Background Amino acid metabolism is dysregulated in colorectal cancer patients; however, it is not clear whether pre-diagnostic levels of amino acids are associated with subsequent risk of colorectal cancer. We investigated circulat‑ ing levels of amino acids in relation to colorectal cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) and UK Biobank ...