Introduction: Non-small cell lung carcinomas (NSCLC) exhibit different microvessel patterns (MVPs). Basal (BA), diffuse (DA) and papillary (PA) patterns show signs of angiogenesis (new blood vessels), while an alveolar pattern indicates that tumors are co-opting existing normal vessels (non-angiogenic alveolar, NAA). NAA tumor growth is known to exist in NSCLC, but little is known about its prognostic ...

<p><i>Background:</i> Cancer is the leading cause of death in Norway, and lifestyle behaviors are a major contributor to cancer risk. This thesis aimed to investigate the association between a healthy lifestyle index (HLI) and cancer incidence and survival among women in Norway. <p><i>Methods:</i> The study used data from the Norwegian Women and Cancer Study, a national prospective cohort of ...

Antimicrobial resistance (AMR), defined as the ability of microorganisms to withstand antimicrobial treatment, is responsible for millions of deaths annually. The rapid spread of AMR across continents warrants systematic changes in healthcare routines and protocols. One of the fundamental issues with AMR spread is the lack of rapid diagnostic tools for pathogen identification and AMR detection. ...

Our current knowledge about the health status and developmental process and outcome of Indigenous Sámi children and youths in the high north (Northern Norway, 68 degrees latitude) is scarce. The present longitudinal study, labeled the Arctic Childhood Study, aims to fll major knowledge gaps related to this topic with a special focus on the incidence of violence, abuse, and neglect as well as ...

Objective: This study investigated how exposure to challenging patient encounters influenced participants’ self-reported quality of life, and how participants’ mentalization capabilities affected the perceptions of challenging patients encounters among Norwegian dentists and dental students.<p> <p>Materials and Methods: Data was collected with an online questionnaire, and a total of 165 dentists (n ...

Boares čállosat juoigama ja sámi kultuvrra birra govvidedje juoigama oassin buot eallima beliin sápmelaččas, leaš dál beaivválaš eallima doaimmain dahje vuoiŋŋalaš ja erenoamáš meanuin ja daguin. Juoigan govviduvvui dárbbašlažžan dearvvašvuhtii, čálgui ja lihkkui. Oanehaččat dadjon oažžot lohkat ahte luohti govviduvvui leame eallindárbun. Odne celket máŋga juoigi ahte luođis lea seamma mearkkašumi ...

Bakgrunn: VIP Snakk om det (tidligere VIP-programmet) er et psykoedukativt program som retter seg mot elever i videregående skoler i alderen 16 og 17 år. Programmet gir informasjon om psykisk helse og psykiske lidelser samt veiledning i hvordan man håndterer slike vansker. Lærere og helsepersonell får opplæring i programmet og hvordan man oppdager problemer hos elevene tidlig for å kunne sette i ...

<p><i>Background:</i> Cancer is a leading cause of premature death worldwide and incidence is expected to rise in the coming decades. Many cohort studies, measuring lifestyle factors at one time-point, have observed that overall healthy lifestyles were inversely related to cancer incidence. However, there is little knowledge on the impact of lifestyle modification within adulthood. <p><i>Methods:</i> ...

Mitochondria are susceptible to damage resulting from their activity as energy providers. Damaged mitochondria can cause harm to the cell and thus mitochondria are subjected to elaborate quality-control mechanisms including elimination via lysosomal degradation in a process termed mitophagy. Basal mitophagy is a house-keeping mechanism fine-tuning the number of mitochondria according to the metabolic ...

Cellular homeostasis is governed by removal of damaged organelles and protein aggregates by selective autophagy mediated by cargo adaptors such as p62/SQSTM1. Autophagosomes can assemble in specialized cup-shaped regions of the endoplasmic reticulum (ER) known as omegasomes, which are characterized by the presence of the ER protein DFCP1/ZFYVE1. The function of DFCP1 is unknown, as are the mechanisms ...