Viser treff 1501-1520 av 10407

    • Sweetened beverages are associated with a higher risk of differentiated thyroid cancer in the EPIC cohort: a dietary pattern approach 

      Zamora-Ros, Raul; Cayssials, Valerie; Clèries, Ramon; Torrents, Maria; Byrnes, Graham; Weiderpass, Elisabete; Sandström, Maria; Almquist, Martin; Boutron-Ruault, Marie-Christine; Tjønneland, Anne; Kyrø, Cecilie; Katzke, Verena A.; Le Cornet, Charlotte; Masala, Giovanna; Krogh, Vittorio; Iannuzzo, Gabriella; Tumino, Rosario; Milani, Lorenzo; Skeie, Guri; Ubago-Guisado, Esther; Amiano, Pilar; Chirlaque, María-Dolores; Ardanaz, Eva; Janzi, Suzanne; Eriksson, Linda; Freisling, Heinz; Heath, Alicia K.; Rinaldi, Sabina; Agudo, Antonio (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-07-30)
      Background - Dietary pattern analysis has gained particular interest, because it reflects the complexity of dietary intake. The aim of this study was to explore the associations between a posteriori dietary patterns, derived using a data-driven approach, and the risk of differentiated thyroid cancer (TC) in Europe.<p> <p>Methods - This investigation included 450,064 adults from the European ...
    • Inflammatory potential of the diet and association with risk of differentiated thyroid cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort 

      Lécuyer, Lucie; Laouali, Nasser; Dossus, Laure; Shivappa, Nitin; Hébert, James R.; Agudo, Antonio; Tjonneland, Anne; Halkjaer, Jytte; Overvad, Kim; Katzke, Verena A.; Le Cornet, Charlotte; Schulze, Matthias B.; Jannasch, Franziska; Palli, Domenico; Agnoli, Claudia; Tumino, Rosario; Dragna, Luca; Iannuzzo, Gabriella; Jensen, Torill Miriam Enget; Brustad, Magritt; Skeie, Guri; Zamora-Ros, Raul; Rodriguez-Barranco, Miguel; Amiano, Pilar; Chirlaque, María-Dolores; Ardanaz, Eva; Almquist, Martin; Sonestedt, Emily; Sandström, Maria; Nilsson, Lena Maria; Weiderpass, Elisabete; Huybrechts, Inge; Rinaldi, Sabina; Boutron-Ruault, Marie-Christine; Truong, Thérèse (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-05-30)
      Purpose - Chronic inflammation is thought to initiate or promote differentiated thyroid cancer (DTC) and previous studies have shown that diet can modulate this inflammatory process. We aimed to evaluate the association of several dietary scores reflecting the inflammatory potential of the diet with DTC risk.<p> <p>Methods - Within the EPIC cohort, 450,063 participants were followed during a mean ...
    • Excess Body Fatness during Early to Mid-Adulthood and Survival from Colorectal and Breast Cancer: A Pooled Analysis of Five International Cohort Studies 

      Charvat, Hadrien; Freisling, Heinz; Noh, Hwayoung; Gaudet, Mia M.; Gunter, Marc J.; Cross, Amanda J.; Tsilidis, Konstantinos K.; Tjønneland, Anne; Katzke, Verena; Bergmann, Manuela; Agnoli, Claudia; Rylander, Charlotta; Skeie, Guri; Jakszyn, Paula; Rosendahl, Ann H.; Sund, Malin; Severi, Gianluca; Tsugane, Shoichiro; Sawada, Norie; Brenner, Hermann; Adami, Hans-Olov; Weiderpass, Elisabete; Soerjomataram, Isabelle; Arnold, Melina (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-02-07)
      Background: Here, we explore the association between excess weight during early to mid-adulthood and survival in patients diagnosed with breast and colorectal cancer, using a pooled analysis of five cohort studies and study participants from 11 countries.<p> <p>Methods: Participant-level body mass index (BMI) trajectories were estimated by fitting a growth curve model using over 2 million repeated ...
    • Lungesykdom hos barn født før uke 32, behandlet ved Nyfødt Intensivseksjonen, Universitetssykehuset Nord-Norge, i perioden 2009-2018 - en populasjonsbasert studie 

      Edvardsen, Håkon (Master thesis; Mastergradsoppgave, 2021-05-31)
      <b>Bakgrunn</b>: Fødsel før 32. svangerskapsuke medfører stor risiko for pulmonal morbiditet. Ved fødsel i en sårbar fase av lungeutviklingen er respirasjonsstøttende behandling nødvendig for å sikre overlevelse. Formålet med denne studien er å kartlegge forekomsten av de vanligste lungesykdommene og den respirasjonsstøttende behandlingen hos barn født før uke 32. <p> <p><b>Metode</b>: Studien ...
    • Impact of Resolvin D1 on the inflammatory phenotype of periodontal ligament cell response to hypoxia 

      Cai, Jiazheng; Liu, Jing; Yan, Jing; Lu, Xuexia; Wang, Xiaoli; Li, Si; Mustafa, Kamal Babikeir Elnour; Wang, Huihui; Xue, Ying; Mustafa, Manal; Kantarci, Alpdogan; Xing, Zhe (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-08-09)
      Objective - Periodontal ligament cells (PDLCs) are critical for wound healing and regenerative capacity of periodontal diseases. Within an inflammatory periodontal pocket, a hypoxic environment can aggravate periodontal inflammation, where PDLCs response to the inflammation would change. Resolvin D1 (RvD1) is an endogenous lipid mediator, which can impact intracellular inflammatory pathways of ...
    • Comparative effectiveness of intracranial hypertension management guided by ventricular versus intraparenchymal pressure monitoring: a CENTER-TBI study 

      Volovici, Victor; Pisică, Dana; Gravesteijn, Benjamin; Dirven, Clemens M. F.; Steyerberg, Ewout W.; Ercole, Ari; Stocchetti, Nino; Nelson, David; Menon, David K; Citerio, Giuseppe; Van Der Jagt, Mathieu; Maas, Andrew I. R.; Haitsma, Iain K.; Lingsma, Hester F.; Vik, Anne; Skandsen, Toril; Andelic, Nada; Røise, Olav; Helseth, Eirik; Andreassen, Lasse; Anke, Audny Gabriele Wagner; Røe, Cecilie (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-06-01)
      <b><p>Objective</b> To compare outcomes between patients with primary external ventricular device (EVD)–driven treatment of intracranial hypertension and those with primary intraparenchymal monitor (IP)–driven treatment. <b><p>Methods</b> The CENTER-TBI study is a prospective, multicenter, longitudinal observational cohort study that enrolled patients of all TBI severities from 62 participating ...
    • Atezolizumab and stereotactic body radiotherapy in patients with advanced non-small cell lung cancer: safety, clinical activity and ctDNA responses—the ComIT-1 trial 

      Horndalsveen, Henrik; Alver, Tine Norman; Dalsgaard, Astrid Marie; Helbekkmo, Nina; Grønberg, Bjørn Henning; Halvorsen, Tarje Onsøien; Ramberg, Christina; Haakensen, Vilde Drageset; Øjlert, Åsa Kristina; Bjaanæs, Maria Moksnes; Helland, Åslaug; Rogg, Lotte Victoria (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-11-04)
      The introduction of immune checkpoint inhibitors has transformed the treatment landscape of metastatic non-small cell lung cancer. However, challenges remain to increase the fraction of patients achieving durable clinical responses to these drugs and to help monitor the treatment effect. In this phase II trial, we investigated the toxicity, systemic responses and circulating tumour DNA responses in ...
    • The immune microenvironment in oral squamous cell carcinoma – characterization and prognostic markers 

      Wirsing, Anna Maria (Doctoral thesis; Doktorgradsavhandling, 2018-09-27)
      Oral squamous cell carcinomas (OSSCs) are aggressive tumors often associated with a low survival rate. The immune system influences the development of OSCCs, and the immune infiltrate surrounding the cancer cells is an indicator of the host’s anti-tumor response. The main aim of this thesis was to describe how the tumor microenvironment in OSCC is organized, and to determine whether different subsets ...
    • Against All Odds? Sami Women’s Lower NEET Experience in An Arctic Context: Education and Work Participation among Multicultural Young People in Northern-Norway, the Norwegian Arctic Adolescent Health Study (NAAHS) 

      Bania, Elisabeth Valmyr; Eckhoff, Christian; Ekornes, Stine M. (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-05-25)
      The present paper explores Sami women’s lower NEET (Not engaged in Education, Employment or Training) experience in an ethnoreligious multicontext perspective. Data are derived from a cross-sectional cohort and registry follow-up study in Northern Norway, 2003–2012, and data from Statistics Norway are included for an up-to date data analysis (2021). This is a cross-sectional cohort and registry data ...
    • A Longitudinal Study of Semantic Networks in Schizophrenia and other Psychotic Disorders Using the Word Association Task 

      Pintos, Andrea Stephanie; Hui, Christy Lai-Ming; De Deyne, Simon; Cheung, Charlton; Ko, Wai Tung; Nam, Suen Yi; Chan, Sherry Kit-Wa; Chang, Wing-Chung; Lee, Edwin Ho-Ming; Lo, Alison Wai-Fan; Lo, Tak-Lam; Elvevåg, Brita; Chen, Eric Yu-Hai (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-08-24)
      The underpinnings of language deviations in psychotic symptoms (eg, formal thought disorder, delusions) remain unclear. We examined whether the semantic networks underlying word associations are useful predictors of clinical outcomes in psychosis. Fifty-one patients with schizophrenia and other psychotic disorders and 51 matched healthy controls generated words in a Cantonese continued word ...
    • Interventions for osteoarthritis pain: A systematic review with network meta-analysis of existing Cochrane reviews 

      Smedslund, Geir; Kjeken, Ingvild; Musial, Frauke; Sexton, Joseph; Østerås, Nina (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-02-15)
      Objective: To conduct a network meta-analysis comparing all treatments for osteoarthritis (OA) pain in the Cochrane Library.<p> <p>Design: The Cochrane Library and Epistemonikos were searched for randomized controlled trials (RCTs) about treatments for hip and knee OA. We constructed 17 broad categories, comprising drug treatments, exercise, surgery, herbs, orthotics, passive treatments, ...
    • Laser In Situ Keratomileusis (LASIK) Combined with Prophylactic Corneal Cross-Linking for Correction of Myopia: Regional Analysis of Corneal Morphology 

      Zhang, Jia; Chen, Tong; Wang, Junjie; Bao, Fangjun; Chen, Wen; Stojanovic, Aleksandar; Wang, Qinmei; Chen, Shihao (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-05-09)
      Introduction: This study evaluated the outcomes of laser in situ keratomileusis (LASIK) combined with prophylactic corneal collagen cross-linking (CXL) in correcting myopia in cases with increased estimated risk of postoperative corneal ectasia, detected by regional analysis of corneal morphology.<p> <p>Methods: The retrospective study included 180 eyes of 99 patients. Group 1 (94 eyes of ...
    • Correlation of expression of Major Vault Protein with androgen receptor and immune checkpoint protein B7-H3, and with poor prognosis in prostate cancer 

      Nunes-Xavier, Caroline Elisabeth; Emaldi, Maite; Guldvik, Ingrid Jenny; Ramberg, Håkon; Tasken, Kristin Austlid; Mælandsmo, Gunhild Mari; Fodstad, Øystein; Llarena, Roberto; Pulido, Rafael; Lopez, José I. (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-11-24)
      Prostate cancer diagnosis and early stratification is an important aspect to avoid undertreatment of high-risk prostate cancer patients. Major Vault Protein (MVP) has been proposed as a prognostic biomarker in prostate cancer. PTEN and the immune checkpoint protein B7-H3 interact with MVP and are important in prostate cancer progression and therapy response. We evaluated the expression of MVP by ...
    • Weight loss behaviour in obese patients 

      Skogset, Ingar (Master thesis; Mastergradsoppgave, 2020-02-21)
      Background: Obesity is increasing worldwide, and especially amongst the younger population. Many obese people are trying to lose weight without long-term success. There are certain things that they struggle with, and it can vary from patient to patient, but knowing this they can better be helped by professionals. There are many questionnaires for this purpose, most of them with many questions. Aim ...
    • Attitudes of Mental Health Service Users Toward Storage and Use of Electronic Health Records 

      Bakken, Victoria; Koposov, Roman A; Røst, Thomas Brox; Clausen, Carolyn; Nytrø, Øystein; Leventhal, Bennett; Westbye, Odd Sverre; Koochakpour, Kaban; Mandahl, Arthur; Hafstad, Hege; Skokauskas, Norbert (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-09-01)
      Objective: Electronic health records (EHRs) are used for both clinical practice and research. Because mental health service users’ views are underrepresented in perspectives on EHR use, the authors examined service users’ awareness, attitudes, and opinions about EHR data storage and sharing.<p> <p>Methods: A mixed-methods, cross-sectional design was used to examine attitudes of 253 Norwegian ...
    • Lifetime sunburn trajectories and associated risks of cutaneous melanoma and squamous cell carcinoma among a cohort of Norwegian women 

      Lergenmuller, Simon; Rueegg, Corina Silvia; Perrier, Flavie; Robsahm, Trude Eid; Green, Adele C.; Lund, Eiliv; Ghiasvand, Reza; Veierød, Marit Bragelien (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-10-05)
      Importance - To our knowledge, no study has prospectively investigated sunburn patterns over age periods from childhood to adulthood and their associations with skin cancer risk.<p> <p>Objective - To identify lifetime trajectories of sunburns and compare the association between these trajectories and subsequent risk of cutaneous melanoma and squamous cell carcinoma (cSCC).<p> <p>Design, ...
    • Cooling to hypothermic circulatory arrest by immersion vs. cardiopulmonary bypass (CPB): Worse outcome after rewarming in immersion cooled pigs 

      Filseth, Ole Magnus; Hermansen, Stig Eggen; Kondratyev, Timofey; Sieck, Gary C.; Tveita, Torkjel (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-03-31)
      Introduction: Cooling by cardiopulmonary bypass (CPB) to deep hypothermic cardiac arrest (HCA) for cardiac surgical interventions, followed by CPB-rewarming is performed on a routine basis with relatively low mortality. In contrast, victims of deep accidental hypothermia rewarmed with CPB generally have a much worse prognosis. Thus, we have developed an intact pig model to compare effects on ...
    • Regional Variation in Utilisation of Healthcare Services - A study on hospital care in Norway 

      Rudolfsen, Jan Håkon (Doctoral thesis; Doktorgradsavhandling, 2023-02-28)
      <p><i>Background:</i> In 1938, J. Alison Glover published a study on incidence of tonsillecto-mies in school children, demonstrating variation in treatment rates across school districts. Consequently, it rates raised questions as to what determines when to treat a patient. After Wennberg and Gittelsohns’ paper ‘Small Area Variations in Health Care Delivery’ was pub-lished in 1973, it became clear ...
    • Management of bleeding risk in patients who receive anticoagulant therapy for venous thromboembolism: Communication from the ISTH SSC Subcommittee on Predictive and Diagnostic Variables in Thrombotic Disease 

      den Exter, Paul L.; Woller, Scott C.; Robert-Ebadi, Helia; Masias, Camila; Morange, Pierre-Emmanuel; Castelli, David; Hansen, John Bjarne; Geersing, Geert-Jan; Siegal, Deborah M.; de Wit, Kerstin; Klok, Frederikus A. (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-07-20)
      Patients with acute venous thromboembolism (VTE) require anticoagulant therapy to prevent recurrent VTE and death, which exposes them to an inherent increased risk of bleeding. Identification of patients at high risk of bleeding, and mitigating this risk, is an essential component of the immediate and long-term therapeutic management of VTE. The bleeding risk can be estimated by either implicit ...
    • Glioblastoma PET/MRI: kinetic investigation of [<sup>18</sup>F]rhPSMA-7.3, [<sup>18</sup>F]FET and [<sup>18</sup>F]fluciclovine in an orthotopic mouse model of cancer 

      Lindemann, Marcel; Oteiza, Ana; Martin-Armas, Montserrat; Guttormsen, Yngve; Moldes-Anaya, Angel; Berzaghi, Rodrigo; Bogsrud, Trond; Bach-Gansmo, Tore; Sundset, Rune; Kranz, Mathias (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-11-22)
      <b><p>Purpose</b> Glioblastoma multiforme (GBM) is the most common glioma and standard therapies can only slightly prolong the survival. Neo-vascularization is a potential target to image tumor microenvironment, as it defines its brain invasion. We investigate [<sup>18</sup>F]rhPSMA-7.3 with PET/MRI for quantitative imaging of neo-vascularization in GBM bearing mice and human tumor tissue and compare ...