Background: Accidental hypothermia (AH) is an unintended decrease in body core temperature (BCT) to below 35°C. We present an update on physiological/pathophysiological changes associated with AH and rewarming from hypothermic cardiac arrest (HCA).<p> <p>Temperature Regulation and Metabolism: Triggered by falling skin temperature, Thyrotropin-Releasing Hormone (TRH) from hypothalamus induces ...

The purpose of the present study was to examine vulnerability factors in expecting parents that might lead to mental illness in the perinatal period. Specifcally, we studied how parental early adversity, attentional bias to infant faces, repetitive negative thinking, and demographic factors, were associated with pre- and postnatal depressive symptoms and parenting stress. Participants were expecting ...

Veiledere innen helse- og sosialfaglige velferdstjenester er i daglig kontakt med mennesker som har opplevd traumer og har utfordringer på mange livsområder: arbeid, bolig, økonomi, og sosialt: psykiske og fysiske helseutfordringer. Å stå i disse møtene krever mellommenneskelig kompetanse og trygghet. Forskning indikerer at mange fagprofesjoner opplever at de ikke har tid til å bygge relasjoner, og ...

PoxtA and OptrA are ATP binding cassette (ABC) proteins of the F subtype (ABCF). They confer resistance to oxazolidinone and phenicol antibiotics, such as linezolid and chloramphenicol, which stall translating ribosomes when certain amino acids are present at a defined position in the nascent polypeptide chain. These proteins are often encoded on mobile genetic elements, facilitating their rapid ...

Purpose: Human epidermal growth factor receptor 2 positive (HER2+) breast cancers responding poorly to targeted therapy need improved treatment options. miR-101-5p has shown tumor-suppressive properties in multiple cancer forms, and we assessed the effect and mechanism of action of this miRNA in HER2+ breast cancer.<p> <p>Methods: Expression levels of miR-101-5p in two clinical datasets, TCGA and ...

Previous studies indicate sex differences in incidence and severity of bloodstream infections (BSI). We examined the effect of sex on risk of BSI, BSI mortality, and BSI caused by the most common infecting bacteria. Using causal mediation analyses, we assessed if this effect is mediated by health behaviours (smoking, alcohol consumption), education, cardiovascular risk factors (systolic blood pressure, ...

The total prevalence of diabetes and vascular complications is increasing. Consequently, it is important to provide diabetes treatment according to the National clinical guideline for the management of diabetes and allocate individuals to the right level of health care in line with the National guideline for prioritization in specialist health care – Endocrinology and endocrine surgery. We used data ...

Ulcerative colitis (UC) is a chronic inflammatory bowel disease involving the mucosal lining of the large bowel (colon and rectum). Common symptoms include bouts of diarrhoea, rectal bleeding and abdominal pain. The pathogenesis of UC is complex and multifactorial. This thesis investigated interleukin 33 (IL-33), an alarmin of the innate immune system. IL-33 is of interest as it is found to be ...

Background: ICU patients’ family members are in a new, uncertain, and vulnerable situation due to the patient’s critical illness and complete dependence on the ICU nurses and physicians. Family members’ feeling of being cared for is closely linked to clinicians’ attitudes and behavior.<p> <p>Aim: To explore ICU nurses’ and physicians’ bedside interaction with critically ill ICU patients´ families ...

Background: The COVID-19 pandemic lockdown has had a profound impact on physical and mental well-being throughout the world. Previous studies have revealed that complementary and alternative medicine (CAM) is frequently used for, and can be potential benefcial for strengthening physical mental resilience. The aims of this study were therefore to determine the prevalence and reasons for use of CAM ...