Det helsevitenskapelige fakultet: Nye registreringer
Viser treff 2441-2460 av 10422
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Changes in the secretory profile of NSCLC-associated fibroblasts after ablative radiotherapy: Potential impact on angiogenesis and tumor growth
(Journal article; Tidsskriftartikkel; Peer reviewed, 2014-03-05)In the context of radiotherapy, collateral effects of ablative ionizing radiation (AIR) on stromal components of tumors remains understudied. In this work, cancer-associated fibroblasts (CAFs) isolated from freshly resected human lung tumors were exposed to AIR (1x18Gy) and analyzed for their release of paracrine factors. Inflammatory mediators and regulators of angiogenesis and tumor growth were ... -
Evaluation of the performance of two prediction models, the IrisPlex and the novel EC12 model, for eye colour predictions in a Norwegian population.
(Mastergradsoppgave; Master thesis, 2020-06-12)Biological material obtained from a crime scene is used to generate DNA-profile by typing short tandem repeat (STR) markers. However, if the STR-profile do not match the DNA profile of suspects or from a crime DNA database, the investigation can go towards typing markers that can estimate externally visible characteristics (EVCs). EVCs can function as a “biological witness” and thus aid a police ... -
Managers as Moral Leaders: Moral Identity Processes in the Context of Work
(Journal article; Tidsskriftartikkel; Peer reviewed, 2020-04-15)This qualitative study explores how business leaders narrate their personal ways of recognizing, reasoning, and resolving moral conficts and what these stories reveal about their moral identity processes within organizational contexts. Based on interviews with 25 business leaders, 4 moral identity statuses were identifed: achievement (commitment to a personally meaningful moral value framework ... -
Symptoms of Anxiety, Depression, and Post-Traumatic Stress Disorder in Health Care Personnel in Norwegian ICUs during the First Wave of the COVID-19 Pandemic, a Prospective, Observational Cross-Sectional Study.
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-06-08)Background: The COVID-19 pandemic has induced demanding work situations in intensive care units (ICU). The objective of our study was to survey psychological reactions, the disturbance of social life, work effort, and support in ICU nurses, physicians, and leaders. Methods: From May to July 2020, this cross-sectional study included 484 ICU professionals from 27 hospitals throughout Norway. Symptoms ... -
Palliative non-small cell lung cancer treatment and end-of-life care stratified by sex and childlessness: an important interplay in unmarried patients?
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-03-22)Purpose To analyze the interplay of sex and presence of children in unmarried patients with non-small cell lung cancer, because previous studies suggested sex-related disparities. Adult children may participate in treatment decisions and provision of social support or home care.<p> <p>Methods Retrospective single-institution analysis of 186 unmarried deceased patients, managed according to ... -
An epidemiologic risk prediction model for ovarian cancer in Europe: The EPIC study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2015-03-05)Background: Ovarian cancer has a high case-fatality ratio, largely due to late diagnosis. Epidemiologic risk prediction models could help identify women at increased risk who may benefit from targeted prevention measures, such as screening or chemopreventive agents.<p> <p>Methods: We built an ovarian cancer risk prediction model with epidemiologic risk factors from 202 206 women in the European ... -
Risk of venous thromboembolism from use of oral contraceptives containing different progestogens and oestrogen doses: Danish cohort study, 2001-9
(Journal article; Tidsskriftartikkel; Peer reviewed, 2011-10-25)Objective To assess the risk of venous thromboembolism from use of combined oral contraceptives according to progestogen type and oestrogen dose.<p> <p>Design National historical registry based cohort study. <p>Setting Four registries in Denmark. <p>Participants Non-pregnant Danish women aged 15-49 with no history of thrombotic disease and followed from January 2001 to December 2009. <p>Main ... -
Har vi glemt noe?
(Mastergradsoppgave; Master thesis, 2020-06-09)Bakgrunn: Gjenglemt kirurgisk gjenstand (RSI) er en alvorlig komplikasjon til kirurgi som i stor grad er mulig å unngå, men skjer til tross for at det er utarbeidet retningslinjer og prosedyrer for telling av kirurgisk utstyr. Tidligere studier viser at ved en stor andel av hendelser med RSI, er det gjennomført telling av kirurgisk utstyr, uten påvist avvik. Formål: Denne studien har som formål ... -
Hvilke erfaringer har sykepleiere med å bevare PICC-line hos pasienter i kreftforløpene gjennom å forhindre kateterrelaterte infeksjoner og andre komplikasjoner?
(Mastergradsoppgave; Master thesis, 2020-06-04)Bakgrunn: Masteroppgaven i sykepleie med fagfordypning i infeksjonssykepleie omhandler PICC-line til kreftpasienter. PICC-line et perifert innlagt sentralvenøst kateter som er alternativ til sentralvenøst kateter til middels og langtidsbruk. Hensikt: Hensikten med masteroppgaven i sykepleie er å utforske sykepleieres erfaringer med å bevare PICC-line hos pasienter i kreftforløpene gjennom å forhindre ... -
Helserelatert livskvalitet etter traumatisk hodeskade
(Mastergradsoppgave; Master thesis, 2020-06-04)Traumatisk hodeskade rammer pasienter og deres pårørende og har stor påvirkning på livet deres etter skaden. Valg av tema ble utviklet på bakgrunn av en undring om hvilke konsekvenser den medisinske og intensivsykepleiefaglige behandlingen kan føre til, hva som er beste praksis, og hva som på sikt kan bidra til å bedre og predikere utkomme for pasientene. Denne studien er en delstudie av multisenterstudiet ... -
Impact of hidradenitis suppurativa on work loss, indirect costs and income
(Journal article; Tidsskriftartikkel; Peer reviewed, 2018-08-18)Background Hidradenitis suppurativa (HS), a chronic cutaneous disease, can negatively affect work life. Objectives This retrospective cohort study evaluates the indirect burden among employed patients with HS in the U.S.A.<p> <p>Methods Newly diagnosed and general patients with HS, who were employees (age 18–64 years) from a large claims database (Q1 1999 to Q1 2015), were matched 1 : 5 to ... -
Struggling for existence-Life situation experiences of older persons with mental disorders
(Journal article; Tidsskriftartikkel; Peer reviewed, 2012-06-07)Older persons with mental disorders represent a vulnerable group of people with extensive and complex needs. The older population is rapidly increasing worldwide and, as a result of deinstitutionalization in mental health care, older persons are remaining at home to a greater extent. Although they constitute a large proportion of the population, older persons with mental disorders have been ... -
Content of endothelial progenitor cells in autologous stem cellgrafts predict survival after transplantation for multiplemyeloma
(Journal article; Tidsskriftartikkel; Peer reviewed, 2015-02-14)Multiple myeloma (MM) is considered an incurable B cell malignancy, although many patients can benefit from high-dose therapy with autologous stem cell transplantation (ASCT) as a first-line treatment. In nonHodgkin lymphoma (NHL), ASCT is usually performed after relapse with curative intent. Disease progression is often associated with increased angiogenesis, in which endothelial progenitor cells ... -
Association of vitamin D status with arterial blood pressure and hypertension risk: A mendelian randomisation study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2014-06-25)Background Low plasma 25-hydroxyvitamin D (25[OH]D) concentration is associated with high arterial blood pressure and hypertension risk, but whether this association is causal is unknown. We used a mendelian randomisation approach to test whether 25(OH)D concentration is causally associated with blood pressure and hypertension risk.<p> <p>Methods In this mendelian randomisation study, we generated ... -
Risk Factors and Triggers of Venous Thromboembolism in Patients with Myocardial Infarction
(Doctoral thesis; Doktorgradsavhandling, 2022-06-17)<p>During the past decades, extensive data from the general population have revealed that patients with acute myocardial infarction (MI) are at increased risk of venous thromboembolism (VTE, i.e., deep vein thrombosis [DVT] and pulmonary embolism [PE]). The risk is highest in the initial 0-6 months following an acute MI, and declines rapidly thereafter. The explanation for the observed association ... -
Geographic and socioeconomic variation in the utilisation of specialist health care services in Norway – Three selected health care services
(Doctoral thesis; Doktorgradsavhandling, 2022-06-21)<p>The overall theme of this thesis is geographic and socioeconomic variation in the use of specialist health care services. Three different health care services were studied. Complete population data on individual level with high level of quality from nationwide registries (i.e., The Norwegian Patient Registry, The Cancer Registry of Norway and Statistics Norway) were used in the analysis. <p>The ... -
Socioeconomic and geographic differences in ablation of atrial fibrillation in Norway - a national cohort study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-02-14)<p><i>Background -</i> The aim of this study was to analyse whether there are patient related or geographic differences in the use of catheter ablation among atrial fibrillation patients in Norway. <p><i>Methods -</i> National population-based data on individual level of all Norwegians aged 25 to 75 diagnosed with atrial fibrillation from 2008 to 2017 were used to study the proportion treated with ... -
Oral contraceptive use and reproductive factors and risk of ovarian cancer in the European Prospective Investigation into Cancer and Nutrition
(Journal article; Tidsskriftartikkel; Peer reviewed, 2011-09-03)BACKGROUND: It is well established that parity and use of oral contraceptives reduce the risk of ovarian cancer, but the associations with other reproductive variables are less clear.<p> <p>METHODS: We examined the associations of oral contraceptive use and reproductive factors with ovarian cancer risk in the European Prospective Investigation into Cancer and Nutrition. Among 327 396 eligible ... -
Maternal Blood Levels of Toxic and Essential Elements and Birth Outcomes in Argentina: The EMASAR Study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-03-18)Pregnant women’s levels of toxic and essential minerals have been linked to birth outcomes yet have not been adequately investigated in South America. In Argentina, n = 696 maternal whole blood samples from Ushuaia (n = 198) and Salta (n = 498) were collected in 2011–2012 among singleton women at 36 ± 12 h postpartum and analyzed for blood concentrations of arsenic (As), cadmium (Cd), mercury (Hg), ... -
Atopic disease in relation to Staphylococcus aureus carriage and spa type distribution in a subarctic adult population
(Master thesis; Mastergradsoppgave, 2019-06-02)Atopic diseases are common, and the atopic epidemic has ravaged through the westernized countries and is heading for the developing countries too. Despite being a common disease, however, treatment and diagnostic options are still lacking. The immune system and development of atopic disease are interconnected with the environment through exposures or lack thereof. The microbiota of the mucosal ...