Det helsevitenskapelige fakultet: Nye registreringer
Viser treff 341-360 av 10396
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Protocol of a randomised, controlled trial comparing immediate curative therapy with conservative treatment in men aged ≥75 years with non-metastatic high-risk prostate cancer (SPCG 19/GRand-P)
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-03-12)Background Older men (aged ≥75 years) with high risk, non-metastatic prostate cancer (PCa) are increasingly treated with curative therapy (surgery or radiotherapy). However, it is unclear if curative therapy prolongs life and improves health-related quality of life (HRQoL) in this age group compared to conservative therapy, which has evolved considerably during the last decade.<p> <p>Study ... -
Persistent Use of Prescription Opioids Before and After Lumbar Spine Surgery: Observational Study With Prospectively Collected Data From Two Norwegian National Registries
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-07-15)Study Design - Prospective pharmacoepidemiologic study.<p> <p>Objective - To investigate clinical and sociodemographic factors associated with persistent opioid use in the years following spine surgery among patients with persistent opioid use preceding lumbar spine surgery.<p> <p>Summary of Background Data - It is unknown whether successful spine surgery leads to a cessation of preoperative ... -
Radiation-induced effects on TGF-beta and PDGF receptor signaling in cancer-associated fibroblasts
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-03-15)Background - Cancer-associated fibroblasts (CAFs) consist of heterogeneous connective tissue cells and are often constituting the most abundant cell type in the tumor stroma. Radiation effects on tumor stromal components like CAFs in the context of radiation treatment is not well-described.<p> <p>Aim - This study explores potential changes induced by ionizing radiation (IR) on platelet-derived ... -
Staff perceptions of support for early menarche in Australian primary schools: a qualitative study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-11-11)The age of the onset of menstruation, termed menarche, has been declining for decades worldwide. Approximately 12% of Australian girls reach menarche between eight to 11 years of age. Current health and physical education subject guidelines from the Australian Curriculum Assessment and Reporting Authority state that puberty education should be introduced to students between year levels five to six ... -
Mental health, wellbeing, and support needs of nursing students – ‘Help! I’m overwhelmed, I need an extension’
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-06-27)High and increasing prevalence rates of mental health problems among young people mean that youth mental health is a key priority for policymakers worldwide. -
Pushed to the Fringe – The Impact of Vaccine Hesitancy on Children and Families
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-06-15)Vaccine hesitancy has been described as any delay or refusal of vaccines despite their availability and is increasing in Australia and other middle to high-income countries. The aim of this study is to gain a deep understanding of the experiences and influences on vaccine hesitant children and their families. A qualitative interview approach was undertaken with vaccine hesitant parents and pregnant ... -
First Nations people often take on the ‘cultural load’ in their workplaces. Employers need to ease this burden
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-01-31)It’s good practice for employers to consult staff when forming policies or guidelines. However, for some staff from diverse backgrounds, this creates extra work and pressure. -
Atg8 family proteins, LIR/AIM motifs and other interaction modes
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-03-19)The Atg8 family of ubiquitin-like proteins play pivotal roles in autophagy and other processes involving vesicle fusion and transport where the lysosome/vacuole is the end station. Nuclear roles of Atg8 proteins are also emerging. Here, we review the structural and functional features of Atg8 family proteins and their protein-protein interaction modes in model organisms such as yeast, Arabidopsis, ... -
LC3B is a cofactor for LMX1B-mediated transcription of autophagy genes in dopaminergic neurons
(Journal article; Tidsskriftartikkel, 2023-04-10)It is becoming increasingly clear that the Atg8 family of autophagy proteins have roles not only in the cytoplasm, but also in the cell nucleus. In this issue, Jimenez-Moreno et al. (2023. J. Cell Biol. <a href=https://doi.org/10.1083/jcb.201910133>https://doi.org/10.1083/jcb.201910133</a>) report that nuclear LC3B binds to the LIM homeodomain transcription factor LMX1B and acts as a cofactor for ... -
Jordmødres bruk av fødestillinger i forløsning av barnet og sammenhengen med egen preferanse, kvinners brukermedvirkning og rammefaktorer relatert til klinisk praksis - en tverrsnittstudie
(Mastergradsoppgave; Master thesis, 2021-03-18)Abstrakt Tittel: Jordmødres bruk av fødestillinger i forløsning av barnet og sammenhengen med egen preferanse, kvinners brukermedvirkning og rammefaktorer relatert til klinisk praksis. Hensikt: Hensikten med studien er gjennom å kartlegge selvrapporterte fødestillinger jordmor har brukt siste året, å undersøke hvilke faktorer som påvirker bruk av fødestilling. Metode: Tverrsnittstudi ... -
HIV Infected African Children: Gut microbiota in relation to chronic lung disease and long-term antibiotic treatment
(Doctoral thesis; Doktorgradsavhandling, 2024-04-19)More than half of the population with HIV in the world live in sub-Saharan Africa. HIV-associated chronic lung disease is the most prevalent comorbidity among children and adolescents with HIV in this region. The pathogenesis is multifactorial and thought to be a result of chronic immune activation and repeated lung injury. CD4+ T-cells are the main target for HIV infection. As the majority of CD4+ ... -
Jordmødres erfaringer i møte med innvandrerkvinner i fødsel som ikke behersker det norske språk.
(Mastergradsoppgave; Master thesis, 2022-03-15)Hensikt: Å utforske norske jordmødres erfaringer i møte med innvandrerkvinner i fødsel som ikke behersker det norske språk. Metode: Kvalitativ metode med åtte individuelle intervju. I dette studiet ble det brukt en hermeneutisk tilnærming og data ble analysert etter livsverden hermeneutikk. Funn: Funnene presenteres gjennom fem temaer: språkbarrierer kan gi disharmoni og hindre deltakelse, ... -
Cystatin C-Based Equation to Estimate GFR without the Inclusion of Race and Sex
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-01-26)BACKGROUND - The accuracy of estimation of kidney function with the use of routine metabolic tests, such as measurement of the serum creatinine level, has been controversial. The European Kidney Function Consortium (EKFC) developed a creatinine-based equation (EKFC eGFRcr) to estimate the glomerular filtration rate (GFR) with a rescaled serum creatinine level (i.e., the serum creatinine level is ... -
Transcranial direct current stimulation for chronic headaches, a randomized, controlled trial
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-02-27)Background and objectives: Chronic headaches are a frequent cause of pain and disability. The purpose of this randomized trial was to examine whether transcranial direct current stimulation (tDCS) applied to the primary motor cortex, reduces pain and increases daily function in individuals suffering from primary chronic headache.<p> <p>Materials and methods: A prospective, randomized, controlled ... -
Mental Health, Work, Welfare and Vocational Rehabilitation. A Comprehensive Study of Young Adults in the Norwegian Welfare State
(Doctoral thesis; Doktorgradsavhandling, 2024-04-11)<p><i>Background:</i> Despite Norway's high living standards and robust welfare system, a paradox exists concerning its young working-age adults - low unemployment but high and increasing uptake of health-related welfare benefits, mainly due to mental health problems. My study investigates the relationship between Norway's welfare system, young adults' reliance on health-related benefits, social ... -
Educational inequality in population-based health studies
(Doctoral thesis; Doktorgradsavhandling, 2024-04-04)When comparing groups in the society, one can observed systematic differences in health. The higher the education the group has, the higher the proportion of the group’s member have good health. These differences are known as social inequality in health. Information concerning an individual’s socioeconomic status is often collected through self-administrated questionnaires within epidemiological ... -
Associations Between Self-Rated Health and Mortality in the Norwegian Women and Cancer (NOWAC) Study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2024-02-20)Purpose: We investigated the association between self-rated health (SRH) and cancer incidence and SRH and all-cause mortality among Norwegian women.<p> <p>Population and Methods: We used data from 110,104 women in the Norwegian Women and Cancer (NOWAC) cohort aged 41– 70 years at baseline. We used flexible parametric survival analysis with restricted cubic splines to calculate hazard ratios (HRs) ... -
"Det handler jo om hvordan en spør" : en kvalitativ metasyntese om fysioterapeuters tverrsektorielle samhandling
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-11-20)Bakgrunn: Helsetjenestens organisering med en inndeling i spesialist- og kommunehelsetjeneste krever i stor grad samhandling på tvers av sektorene. Fysioterapeuters praktiske tilnærming til faget kan skape utfordringer for samhandling på tvers av organisatoriske grenser med ulike kontekstuelle og kulturelle rammer. Hensikten med denne studien er å undersøke fysioterapeuters intraprofesjonelle ... -
A Systems Epidemiology Approach to Breast Cancer and Parity. The Norwegian Women and Cancer (NOWAC) Study
(Doctoral thesis; Doktorgradsavhandling, 2024-04-04)The incidence and prevalence of breast cancer (BC) are increasing worldwide. The reasons for this trend are partly unknown. BC has several well documented modifiable and non-modifiable risk factors. The only known, natural protective factors are breastfeeding and parity. The current paradigm is that the protective effect of parity is mediated by permanent genomic changes in a woman’s breast tissue ... -
Most common health problems in general practice among adolescents, and young adults’ survivors of lymphoma: a register-based cohort study in Norway
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-10-28)Background - The aim was to investigate the distribution of health problems in general practice (GP) among adolescent and young adult (AYA) survivors of lymphoma and to compare problem rates with the general population.<p> <p>Methods - All GP consultations between 2006 and 2020 were identified from the national GP claims register. Diseases and complaints presented 3–10 years after the cancer ...