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norskDet helsevitenskapelige fakultet: Nye registreringer
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Ungdom og familie ressurser - En studie av deltakelse i idrett, friluftsliv og snøscooterkjøring blant ungdom i Finnmark med ulik familieøkonomi
(Master thesis; Mastergradsoppgave, 2021-01-19)Formålet med denne studien var å belyse sosiale forskjeller i deltakelse i fritidsaktiviteter og bruk av fritidsarenaer blant ungdom med ulik sosioøkonomisk status i Finnmark. Ved å se på ungdom fra familier med ulik økonomi og ulik tilgang til materielle ressurser, var siktemålet å få kunnskap om hvordan familiens sosioøkonomiske status påvirker ungdoms deltakelse i idrett og fysisk aktivitet, ... -
Kunnskapsoppsummering og klassifisering av tiltaket: Circle of Security Virginia – Gruppemodellen (COS-VG) (2. utg.)
(Journal article; Tidsskriftartikkel; Peer reviewed, 2020-09-02)<i>BAKGRUNN</i> - Circle of Security (COS), eller <i>Trygghetssirkelen</i> på norsk, er en gruppe intervensjoner utviklet for å fremme god tilknytning mellom foreldre og barn. Intervensjonene retter seg primært mot foreldrenes evne til å forstå barnets grunnleggende behov for trygghet, tilhørighet og autonomi slik at barnets trygghetsfølelse og selvforståelse øker. Denne kunnskapsoppsummeringen ... -
Kunnskapsoppsummering og klassifisering av tiltaket: Telemarksmodellen: Vegen blir til mens vi går den sammen (1.utg.)
(Journal article; Tidsskriftartikkel; Peer reviewed, 2020-12-01)<i>Bakgrunn</i> - Telemarksmodellen er en kursrekke utviklet for å fremme psykisk helse og forebygge sosiale vansker for barn som har forståelsesvansker i form av en lett psykisk utviklingshemming. Kursene gis når barnet går på mellomtrinnet i barneskole, ungdomstrinnet og i videregående skole. Formen er psykoedukativ hvor en veksler mellom informasjon, råd, veiledning og samtale om et hverdagsliv ... -
Irradiated tumor fibroblasts avoid immune recognition and retain immunosuppressive functions over NK cells
(Journal article; Tidsskriftartikkel, 2021-01-22)Recent studies have demonstrated that radiotherapy is able to induce anti-tumor immune responses in addition to mediating direct cytotoxic effects. Cancer-associated fibroblasts (CAFs) are central constituents of the tumor stroma and participate actively in tumor immunoregulation. However, the capacity of CAFs to influence immune responses in the context of radiotherapy is still poorly understood. ... -
Analysis of medico-social factors for return to work among patients presenting with haematological malignancy (adamantine): Results of a 'pilot study'
(Journal article; Tidsskriftartikkel; Peer reviewed, 2020-07-02)<i>Objective</i> - The aim of this study was to describe return to work determinants in patients with haematological malignancy.<p> <p><i>Results</i> - This medico-social pilot study included patients with haematological malignancy in the <i>département</i> of Calvados, aged 18 to 55 years, diagnosed between 1st January and 31st December 2010 and alive at 1st January 2015. Patients were identified ... -
Surgeon’s experience and clinical outcome after retropubic tension‐free vaginal tape - A case series
(Journal article; Tidsskriftartikkel; Peer reviewed, 2020-02-27)<i>Introduction</i> - The retropubic tension‐free vaginal tape procedure has been the preferred method for primary surgical treatment of stress and stress‐dominant mixed urinary incontinence in women for more than 20 years. In this study, we assessed associations between surgeon's experience with the primary tension‐free vaginal tape procedure and both perioperative complications and recurrence ... -
Identification and experimental confirmation of novel cGMP efflux inhibitors by virtual ligand screening of vardenafil-analogues
(Journal article; Tidsskriftartikkel; Peer reviewed, 2020-03-28)<i>Background</i> - Clinical studies have reported overexpression of PDE5 and elevation of intracellular cyclic GMP in various types of cancer cells. ABCC5 transports cGMP out of the cells with high affinity. PDE5 inhibitors prevent both cellular metabolism and cGMP efflux by inhibiting ABCC5 as well as PDE5. Increasing intracellular cGMP is hypothesized to promote apoptosis and growth restriction ... -
CALCOCO1 acts with VAMP ‐associated proteins to mediate ER ‐phagy
(Journal article; Tidsskriftartikkel; Peer reviewed, 2020-06-11)The endoplasmic reticulum (ER) plays important roles in protein synthesis and folding, and calcium storage. The volume of the ER and expression of its resident proteins are increased in response to nutrient stress. ER‐phagy, a selective form of autophagy, is involved in the degradation of the excess components of the ER to restore homeostasis. Six ER‐resident proteins have been identified as ER‐phagy ... -
Biomarkers of major bleeding after incident venous thromboembolism
(Doctoral thesis; Doktorgradsavhandling, 2021-03-23)Major bleeding (MB) events are feared and potentially fatal complications of anticoagulant treatment in patients with venous thromboembolism (VTE). Even though several clinical risk factors are associated with MB risk, the predictive power of currently available risk assessment models remain limited for VTE. The aim of this thesis was to identify biomarkers of MB risk during the first year after an ... -
The relation of gender role attitudes with depression and generalised anxiety disorder in two Russian cities
(Journal article; Tidsskriftartikkel; Peer reviewed, 2020-01-08)<i>Background</i> - Reported traditional gender role attitudes (GRAs) have been related to worse mental health in western countries. This study examined the link of GRAs with symptoms of depression and generalised anxiety disorder (GAD) in two Russian cities.<br><br> <i>Methods</i> - We used interview data from the cross-sectional Know Your Heart Study conducted among 5099 adults aged 35-69 in ... -
Å lede eksperter inn i nye arbeidsmåter. Lederatferd ved implementering av primærhelseteam på fastlegekontor
(Journal article; Tidsskriftartikkel; Peer reviewed, 2020-12-15)Ledelse ved norske fastlegekontor er lite utforsket; fastleger deler ofte på ledelsesfunksjoner, og hver fastlege er i stor grad sin egen leder. Helsemyndighetene i Norge og andre land ønsker tverrfaglige team rundt utvalgte pasientgrupper, men mange fastleger er skeptiske. Artikkelen utforsker lederatferd når fastlegekontor skal utvikles fra en samling solopraksiser under samme tak til å bli ... -
Liposomal delivery of antibiotic loaded nucleic acid nanogels with enhanced drug loading and synergistic anti-inflammatory activity against S. aureus intracellular infections
(Journal article; Tidsskriftartikkel; Peer reviewed, 2020-06-07)The persistence of <i>Staphylococcus aureus</i> has been accredited to its ability to escape immune response via host cell invasion. Despite the efficacy of many antibiotics against <i>S. aureus</i>, the high extracellular concentrations of conventional antibiotics required for bactericidal activity is limited by their low cellular accumulation and poor intracellular retention. While nanocarriers ... -
Sars-CoV-2 hos barn og ungdom i Norge: Påvist smitte, sykehusinnleggelser og underliggende tilstander
(Journal article; Tidsskriftartikkel; Peer reviewed, 2020-06-24)BAKGRUNN - Barn og unge har lavere risiko for sykdom forårsaket av sars-CoV-2. Vi beskriver forekomsten av påvist smitte og innleggelser hos barn og unge under 20 år i Norge, og spesifikt blant dem med underliggende tilstander.<p> <p>MATERIALE OG METODE - Helsedirektoratet har i samarbeid med Folkehelseinstituttet etablert et datauttrekk for å overvåke koronavirusutbruddet. Data fra ... -
FuncPEP: A Database of Functional Peptides Encoded by Non-Coding RNAs
(Journal article; Tidsskriftartikkel; Peer reviewed, 2020-09-23)Non-coding RNAs (ncRNAs) are essential players in many cellular processes, from normal development to oncogenic transformation. Initially, ncRNAs were defined as transcripts that lacked an open reading frame (ORF). However, multiple lines of evidence suggest that certain ncRNAs encode small peptides of less than 100 amino acids. The sequences encoding these peptides are known as small open reading ... -
I don’t want to think about it: A qualitative study of children’s and parents’ experiences with regular needle injections at home
(Journal article; Tidsskriftartikkel; Peer reviewed, 2021-01-22)<i>Background</i> - Overall outcomes of pediatric rheumatic diseases (RD) have improved due to treatment with biologic agents and methotrexate. For many children, this treatment often entails regular needle injections. Pain and fear of needle injections are common in childhood, but how children and parents handle long-term needle injections at home has not been fully explored. This study aimed to ... -
A biomarker approach to explain high cardiovascular disease burden in Russia: insights from population-based studies in Russia and Norway
(Doctoral thesis; Doktorgradsavhandling, 2021-03-25)Although the problem of cardiovascular disease (CVD) in Russia has been the subject of attention for decades, a definitive and comprehensive explanation of why the CVD burden there is so high and generally greater than in many other countries has still not been found. In this thesis, I have attempted to advance research on these issues by examining the role of blood lipids, heart damage biomarkers ... -
Common social determinants for overweight and obesity, and dental caries among adolescents in Northern Norway: a cross-sectional study from the Tromsø Study Fit Futures cohort
(Journal article; Tidsskriftartikkel; Peer reviewed, 2021-02-05)<i>Background</i> - Non-communicable general and oral health conditions share common risk factors. Studies investigating common social determinants as risk factors for overweight/obesity and dental caries among the same adolescents are scarce and inconclusive.<p><p> <i>Methods</i> - This cross-sectional study included data from 464 girls and 494 boys from the population-based Tromsø study Fit ... -
A Holistic Perspective: Exosomes Shuttle between Nerves and Immune Cells in the Tumor Microenvironment
(Journal article; Tidsskriftartikkel; Peer reviewed, 2020-10-31)One of the limitations of cancer research has been the restricted focus on tumor cells and the omission of other non-malignant cells that are constitutive elements of this systemic disease. Current research is focused on the bidirectional communication between tumor cells and other components of the tumor microenvironment (TME), such as immune and endothelial cells, and nerves. A major success of ... -
Current Status of Circulating Tumor Cells, Circulating Tumor DNA, and Exosomes in Breast Cancer Liquid Biopsies
(Journal article; Tidsskriftartikkel; Peer reviewed, 2020-12-11)Breast cancer is the most common cancer among women worldwide. Although the five-, ten- and fifteen-year survival rates are good for breast cancer patients diagnosed with early-stage disease, some cancers recur many years after completion of primary therapy. Tumor heterogeneity and clonal evolution may lead to distant metastasis and therapy resistance, which are the main causes of breast cancer-associated ... -
The value of dynamic infrared thermography in pedicled thoracodorsal artery perforator flap surgery
(Journal article; Tidsskriftartikkel; Peer reviewed, 2020-07-15)<p><i>Background:</i> Dynamic infrared thermography (DIRT) is a noninvasive imaging technique that can provide indirect and real-time information on skin perfusion by measuring skin temperature. Although used in flap surgery, there are no reports on its value in procedures using a pedicled thoracodorsal artery perforator (TDAP) flap. The aim of this study was to assess the usefulness of DIRT in ...
