Chronic wounds are today representing a major challenge in global healthcare due the difficulty to treat as well as the costs for the society. Therefore, improving chronic wound therapy is an urgent need. Curcumin, a polyphenol compound, has shown to have potential in wound therapy due to its anti-inflammatory, anti-infectious and anti-oxidant properties. However, the poor water solubility, low ...

Telerehabilitation (TR) increases accessibility towards pulmonary rehabilitation (PR) in chronic obstructive pulmonary disease (COPD) patients. It appears to be a cost-effective alternative to PR. We aimed to study adherence of COPD patients participating in long-term TR and practical challenges of TR from professional ́s perspective. 40 COPD patients participated in TR for 2 years. Participants ...

Background/aim of the study: Carcinoma-associated Fibroblasts (CAFs) comprise a heterogeneous population of cells and often represent the major cellular component of solid malignancies playing critical roles in tumor progression and metastasis. The purpose of this study was to gain more knowledge on the immunosuppressive traits of CAFs isolated from non-small cell lung carcinomas (NSCLC), and to ...

When bacteria are exposed to antibiotics, the rate of killing can slow down dramatically over time. This phenomenon can be observed both in vitro and in vivo. In vitro, the mechanistic explanations for this can be divided into two main categories: antibiotic persistence and heteroresistance. In vivo, both mechanisms thought to contribute to observed slowdowns in the elimination and as a result may ...

<i>Objectives</i> - To evaluate critical care nurses’ experiences of ICU diaries following the implementation of national recommendations for the use of diaries for critically ill patients.<p><p> <i>Design</i> - A quality improvement project describing the development and implementation of national recommendations (2011), as well as the assessment of the use of diaries in intensive care nursing ...

Background: Mass spectrometry-based proteomics has increasingly been the choice of method for the global analysis of the composition, modification and dynamics of proteins. Quantitative analysis of the proteome with tandem mass tag is a technique for calculating the relative abundance of the proteome in tissues and organelles. In this thesis, present a novel bottom-up method for the quantitative ...

Neuroblastoma is the most common diagnosed tumor in infants and the second most common extracranial tumor of childhood. The survival rate of patients with high-risk neuroblastoma is still very low despite intensive multimodal treatments. Therefore, new treatment strategies are needed. In recent years, miRNA-based anticancer therapy has received growing attention. Advances in this novel treatment ...

Abnormal increases in nucleolar size and number caused by dysregulation of ribosome biogenesis has emerged as a hallmark in the majority of spontaneous cancers. The observed ribosome hyperactivity can be directly induced by the MYC transcription factors controlling the expression of RNA and protein components of the ribosome. Neuroblastoma, a highly malignant childhood tumor of the sympathetic nervous ...

The elderly population is rapidly growing, and elderly individuals are more vulnerable to nutritional problems than other adults. A number of studies have found evidence for adverse health outcomes in elderly patients at risk of malnutrition. However, much of the previous research has been performed in hospital populations or in groups of elderly patients with specific diagnoses. More population-based ...

Prefaktiske tanker – tanker om konsekvenser av tenkte handlinger før de utføres – kan være gunstig for å forstå hvordan fremtidige mål kan oppnås. (Epstude, Scholl & Roese, 2016), mens kontrafaktisk tanker – tanker om hva som alternativt kunne skjedd – er funksjonell ved å hjelpe individet med atferdsregulering (Epstude & Roese, 2008). Denne studien undersøker sammenhengen mellom studenters prefaktiske- ...