Det helsevitenskapelige fakultet: Nye registreringer
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Successful recruitment strategies for prevention programs targeting children of parents with mental health challenges: An international study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2016-03-30)Research substantiates children of parents with mental disorders including substance abuse face increased risk for emotional and behavioral problems. Although evidence suggests that support programs for children enhance resiliency, recruiting children to these groups remains problematic. This study identifies successful recruitment strategies for prevention programs for children of parental ... -
Infertility and incident endometrial cancer risk: A pooled analysis from the epidemiology of endometrial cancer consortium (E2C2)
(Journal article; Tidsskriftartikkel; Peer reviewed, 2015-02-17)Background: Nulliparity is an endometrial cancer risk factor, but whether or not this association is due to infertility is unclear. Although there are many underlying infertility causes, few studies have assessed risk relations by specific causes.<p> <p>Methods: We conducted a pooled analysis of 8153 cases and 11 713 controls from 2 cohort and 12 case-control studies. All studies provided selfreported ... -
Effectiveness of surgery for sciatica with disc herniation is not substantially affected by differences in surgical incidences among three countries: results from the Danish, Swedish and Norwegian spine registries
(Journal article; Tidsskriftartikkel; Peer reviewed, 2018-09-29)Purpose Yearly incidence of surgery for symptomatic lumbar disc herniation varies and is 29/100,000 in Sweden, 46/100,000 in Denmark and 58/100,000 in Norway. This variation was used to study whether diferences in surgical incidence were associated with diferences in preoperative patient characteristics as well as patient-reported outcomes.<p> Methods Data from the national spine registers in ... -
Dexterity and Cognition in Mild Cognitive Impairment: A Pilot Study
(Mastergradsoppgave; Master thesis, 2017-04-29)Previous research has demonstrated that age-related decline in cognitive and sensorimotor functions are related to dexterity and instrumental activities of daily living (IADL). Few studies have closely investigated the association between dexterity and cognitive functions. The purpose of this study was to explore possible differences in dexterity, cognition and IADL function across a group of mild ... -
Prospective study of dietary inflammatory index and risk of breast cancer in Swedish women
(Journal article; Tidsskriftartikkel; Peer reviewed, 2015-09-03)Background: The role of diet in breast cancer (BrCa) aetiology has been studied widely. Although the results are inconsistent, dietary components have been implicated through their effects on inflammation. We examined the association between a dietary inflammatory index (DII) and BrCa incidence in the Swedish Women’s Lifestyle Study.<p> <p>Methods: The DII was computed at baseline from a validated ... -
Fruit and vegetable consumption in relation to hepatocellular carcinoma in a multi-centre, European cohort study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2015-03-05)Background: Vegetable and/or fruit intakes in association with hepatocellular carcinoma (HCC) risk have been investigated in case–control studies conducted in specific European countries and cohort studies conducted in Asia, with inconclusive results. No multi-centre European cohort has investigated the indicated associations. Methods: In 486 799 men/women from the European Prospective Investigation ... -
Dental erosion, prevalence and risk factors among a group of adolescents in Stockholm County
(Journal article; Tidsskriftartikkel; Peer reviewed, 2018-01-11)Aims To investigate the prevalence and risk factors of dental erosion (DE) among a group of adolescents in Stockholm County.<p> <p>Materials and methods This cross sectional cohort study was conducted at three clinics of the Public Dental Service in Stockholm County. Fifteen and 17 year old adolescents (1335) who scheduled their regular dental health examination were asked to participate. After ... -
Relapse risk of endometrial hyperplasia after treatment with the levonorgestrel-impregnated intrauterine system or oral progestogens
(Journal article; Tidsskriftartikkel; Peer reviewed, 2015-12-02)Objective To investigate relapse rates after the successful treatment of patients with non-atypical endometrial hyperplasia who were randomised to either a levonorgestrel-impregnated intrauterine system (LNG-IUS; Mirena ) or two regimens of oral medroxyprogesterone acetate (MPA) after primary histological response.<p> <p>Design A multicentre randomised trial.<p> <p>Setting Ten different ... -
Manipulating fenestrations in young and old liver sinusoidal endothelial cells
(Journal article; Tidsskriftartikkel; Peer reviewed, 2018-12-27)Fenestrations are pores within liver sinusoidal endothelial cells (LSECs) that enable the transfer of substrates (particularly insulin and lipoproteins) between blood and hepatocytes. With increasing age, there are marked reductions in fenestrations, referred to as pseudocapillarization. Currently, fenestrations are thought to be regulated by vascular endothelial growth factor and nitric oxide (NO) ... -
Impact of alcohol drinking on gastric cancer development according to Helicobacter pylori infection status
(Journal article; Tidsskriftartikkel; Peer reviewed, 2015-09-17)Background: Helicobacter pylori are major carcinogen of gastric cancer, but the associations among gastric cancer, H. pylori infection status, and alcohol consumption are not fully described. This study aimed to clarify how H. pylori infection status affects the association between alcohol consumption and gastric cancer risk.<p> <p>Methods: We selected 949 case–cohort participants from the 18 863 ... -
Detection of carbapenemases with a newly developed commercial assay using Matrix Assisted Laser Desorption Ionization-Time of Flight
(Journal article; Tidsskriftartikkel; Peer reviewed, 2018-02-03)This study evaluated the performance of the MBT STAR-Carba kit (Bruker Daltonics), to detect carbapenemase producing Enterobacteriaceae, Pseudomonas aeruginosa and Acinetobacter spp. in comparison with the RAPIDEC® CARBA NP test (BioMerieux). MBT STAR-Carba allowed the detection of carbapenemases in Enterobacteriaceae and P. aeruginosa. -
“Care or control?”: a qualitative study of staff experiences with outpatient commitment orders
(Journal article; Tidsskriftartikkel; Peer reviewed, 2016-02-12)Purpose Outpatient commitment orders are being increasingly used in many countries to ensure follow-up care of people with psychotic disorders after discharge from hospital. Several studies have examined outpatient commitment in relation to use of health care services, but there have been fewer studies of health professionals’ experiences with the scheme. The purpose of this study was to examine ... -
Variations in serum concentrations of selected organochlorines among delivering women in Argentina. The EMASAR study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2017-09-29)The EMASAR study is the first study to describe the body burden of OCs in Argentinian women after delivery. In total, 698 maternal serum samples from Salta (n ¼ 498) and Ushuaia (n ¼ 200) were collected in 2011–2012 and analyzed for a total of 7 polychlorinated biphenyls (PCBs) and 12 pesticide-related compounds. Only 11 of the compounds had detection rates above 60% in one or both places. Compared ... -
The effect of low-dose naltrexone on medication in inflammatory bowel disease: A quasi experimental before-and-after prescription database study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2018-01-27)Background and Aims: Low-dose naltrexone [LDN] is a controversial off-label treatment used by many Crohn’s disease [CD] and ulcerative colitis [UC] patients. A small number of preliminary studies indicate that LDN might be beneficial in CD, but evidence is too scarce to demonstrate efficacy. We sought to examine whether initiation of LDN therapy by patients with inflammatory bowel disease [IBD] ... -
Extracellular vesicles in diagnostics and therapy of the ischaemic heart: Position Paper from the Working Group on Cellular Biology of the Heart of the European Society of Cardiology
(Journal article; Tidsskriftartikkel; Peer reviewed, 2017-11-02)Extracellular vesicles (EVs)—particularly exosomes and microvesicles (MVs)—are attracting considerable interest in the cardiovascular field as the wide range of their functions is recognized. These capabilities include transporting regulatory molecules including different RNA species, lipids, and proteins through the extracellular space including blood and delivering these cargos to recipient ... -
Epigenomic and transcriptomic approaches in the post-genomic era: Path to novel targets for diagnosis and therapy of the ischaemic heart? Position Paper of the European Society of Cardiology Working Group on Cellular Biology of the Heart
(Journal article; Tidsskriftartikkel; Peer reviewed, 2017-04-29)Despite advances in myocardial reperfusion therapies, acute myocardial ischaemia/reperfusion injury and consequent ischaemic heart failure represent the number one cause of morbidity and mortality in industrialized societies. Although different therapeutic interventions have been shown beneficial in preclinical settings, an effective cardioprotective or regenerative therapy has yet to be successfully ... -
Alcohol consumption and common carotid intima-media thickness: The USE-IMT study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2017-05-19) -
Use of repeated blood pressure and cholesterol measurements to improve cardiovascular disease risk prediction: an individual-participant-data meta-analysis
(Journal article; Tidsskriftartikkel; Peer reviewed, 2017-06-13)The added value of incorporating information from repeated blood pressure and cholesterol measurements to predict cardiovascular disease (CVD) risk has not been rigorously assessed. We used data on 191,445 adults from the Emerging Risk Factors Collaboration (38 cohorts from 17 countries with data encompassing 1962–2014) with more than 1 million measurements of systolic blood pressure, total ... -
High prevalence of echocardiographic abnormalities in older HIV-infected children taking antiretroviral therapy
(Journal article; Tidsskriftartikkel; Peer reviewed, 2018-11-28)Background: Antiretroviral therapy (ART) has decreased mortality so that increasing numbers of children with HIV are reaching adolescence. However, longstanding HIV infection and/or its treatment in children is associated with noninfectious complications including cardiac disease. We investigated the prevalence, spectrum and risk factors for echocardiographic abnormalities among children established ... -
Major increase in microbiota-dependent proatherogenic metabolite TMAO one year after bariatric surgery
(Journal article; Tidsskriftartikkel; Peer reviewed, 2016-04-15)Background: Trimethylamine-N-oxide (TMAO) is formed in the liver from trimethylamine (TMA), a product exclusively generated by the gut microbiota from dietary phosphatidylcholine and carnitine. An alternative pathway of TMAO formation from carnitine is via the microbiota-dependent intermediate g-butyrobetaine (gBB). Elevated TMAO levels are associated with cardiovascular disease (CVD), but little ...