Det helsevitenskapelige fakultet: Nye registreringer
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Health anxiety is an important driver of healthcare use
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-02-02)Background: Healthcare use is increasing, and health anxiety (HA) is recognized as an important associated factor. Previous research on the association between HA and healthcare use has mostly explored HA as a dichotomous construct, which contrasts the understanding of HA as a continuous construct, and compared healthcare use to non-use. There is a need for studies that examine the association ... -
Classical and noncanonical functions of miRNAs in cancers
(Journal article; Tidsskriftartikkel; Peer reviewed, 2021-10-30)Alterations in microRNAs (miRNAs) expression are causative in the initiation and progression of human cancers. The molecular events responsible for the widespread differential expression of miRNAs in malignancy are exemplified by their location in cancer-associated genomic regions, epigenetic mechanisms, transcriptional dysregulation, chemical modifications and editing, and alterations in miRNA ... -
Light-curing units used in dentistry: Effect of their characteristics on temperature development in teeth
(Journal article; Tidsskriftartikkel; Peer reviewed, 2021-09-25)This study aimed to investigate pulp chamber and surface temperature development using different LED light curing units (LCUs). Eight brands of LED-LCUs were tested in a laboratory bench model. The pulp chamber and surface temperature were recorded with a type T thermocouple and infrared cameras, respectively. The highest pulp chamber and surface temperature increase was 6.1±0.3°C and 20.1±1.7°C, ... -
General movement optimality score and general movements trajectories following early parent-administrated physiotherapy in the neonatal intensive care unit
(Journal article; Tidsskriftartikkel; Peer reviewed, 2021-10-14)<p><i>Background</i> The Prechtl General Movement Assessment (GMA) is a reliable tool for the functional assessment of the young nervous system. It is based on a global assessment of the quality of infants' movements. In addition, detailed steps of assessment have been developed – one for preterm and term age, and one for use between 3 and 5 months. One potential benefit of such a detailed analysis ... -
Metaproteomic profiling of fungal gut colonization in gnotobiotic mice
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-02-22)<b><p>Background</b> Eukaryotic microbes can modulate mammalian host health and disease states, yet the molecular contribution of gut fungi remains nascent. We previously showed that mice exclusively colonised with fungi displayed increased sensitivity to allergic airway inflammation and had fecal metabolite profiles similar to germ-free mice. This marginal effect on the host metabolome suggested ... -
Responsibilities of Risk: Living With Mental Illness During COVID-19
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-03-10)Following the COVID-19 pandemic, Denmark introduced repeated lockdowns of society, including outreach services and visits from social workers for people living with mental illnesses. Based on ethnographic fieldwork, in this article we explore how people with mental illness react to and manage their lives amid COVID-19 mitigations, focusing on how they experience and negotiate vulnerability at ... -
Prediction of Ventricular Arrhythmias by QRS/QTc - Ratio in Citalopram or Escitalopram Intoxication
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-03-16)<b><p>Background:</b> The U.S. Food and Drug Administration (FDA) has stated that citalopram and escitalopram should not be used at daily doses above 40 mg/20 mg due to risk for development of fatal ventricular arrhythmias like torsade de pointes (TdP). Yet, supratherapeutic serum concentrations of citalopram are common and predicting patients at risk for TdP is of high clinical value. Accordingly, ... -
Improvised use of a digital tool for social interaction in a Norwegian care facility during the COVID-19 pandemic: an exploratory study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-02-01)Background: Digital tools for social communication have been deployed in care facilities during the COVID-19 pandemic to facilitate social connectedness between older people and their next of kin in a safe manner. This study explores how and why health care professionals facilitate the ad hoc and prompt use of a technology for social communication, known as KOMP, in care facilities in western ... -
Writing disorder: The harmful and healing effects of writing in Hornbacher’s Wasted and other anorexia memoirs
(Journal article; Tidsskriftartikkel; Peer reviewed, 2021-10-31)A growing body of evidence points to the potential of life writing about anorexia to foster “disordered reading” practices in certain readers (Seaber, 2016), with particular concerns raised about the breakthrough eating disorder memoir, Marya Hornbacher’s Wasted (1998). With this article, I shift the focus from readers to authors, exploring the positive and negative health consequences of writing ... -
De første radiografene i Norge - yrkesvalget og utdannelsen
(Journal article; Tidsskriftartikkel; Peer reviewed, 2021)<p><i>Innledning:</i> Radiografi er et ungt fag der dokumentasjon av historien og utviklingen i Norge er begrenset. I Norge ble de første radiografene utdannet tidlig på 1970 tallet. Bakgrunnen for å starte utdanningen var mangel på røntgenassistenter, dårlig rekruttering av sykepleiere til ledige stillinger og at andre land i Vest Europa hadde startet å utdanne teknisk personale for å arbeide på ... -
Performance of creatinine-based equations to estimate glomerular filtration rate with a methodology adapted to the context of drug dosage adjustment
(Journal article; Tidsskriftartikkel; Peer reviewed, 2021-10-28)<p><i>Aim:</i> The Cockcroft-Gault (CG) creatinine-based equation is still used to estimate glomerular filtration rate (eGFR) for drug dosage adjustment. Incorrect eGFR may lead to hazardous over- or underdosing. <p><i>Methods:</i> In a cross-sectional analysis, CG was validated against measured GFR (mGFR) in 14 804 participants and compared with the Modification-of-Diet-in-Renal-Diseases (MDRD), ... -
Adverse Effects of Andrographolide Derivative Medications Compared to the Safe use of Herbal Preparations of Andrographis paniculata: Results of a Systematic Review and Meta-Analysis of Clinical Studies
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-01-20)Background and objective: Andrographis paniculata (AP) is a traditionally used herbaceous plant, whose main active constituent is andrographolide. Andrographolide derivative medications and herbal preparations of AP are often used to treat respiratory tract infections. This study aims to systematically evaluate the safety of andrographolide derivative medications and herbal preparations of AP ... -
Non‑linear associations between healthy Nordic foods and all‑cause mortality in the NOWAC study: a prospective study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-01-25)Background: The shape of the associations between intake of foods basic in a healthy Nordic diet and long-term health is not well known. Therefore, we have examined all-cause mortality in a large, prospective cohort of women in Norway in relation to intake of: Nordic fruits and vegetables, fatty fsh, lean fsh, wholegrain products, and low-fat dairy products.<p> <p>Methods: A total of 83 669 women ... -
Prevalens av og risikofaktorer for selvrapportert hjerteinfarkt og atrieflimmer hos samer og ikke-samer i Tromsøundersøkelsen
(Journal article; Tidsskriftartikkel; Peer reviewed, 2021-04-27)Hjerteinfarkt og atrieflimmer er ledende årsaker til mortalitet og morbiditet globalt (1). Det norske dødsårsaksregisteret viser imidlertid at risiko for å dø av hjerte- og kar- sykdommer er mer enn halvert fra år 2000 til 2016 (2). Mannsverk et al. viste i 2012 at nedgangen i mortalitet av koronarsykdom i Tromsø skyldes en nedgang i insidens (3). Senere ble det vist at 66 % av nedgangen ... -
Intraoperative swept-source OCT–based corneal topography for measurement and analysis of stromal surface after epithelial removal
(Journal article; Tidsskriftartikkel; Peer reviewed, 2021-07-01)<p>PURPOSE: To assess intraoperative stromal topography measurements using swept-source optical coherence tomography (OCT)–based topography/tomography after epithelial removal and to analyze the epithelial contribution to the corneal topography and optics. <p>METHODS: This was a prospective series of 22 eyes of 19 patients referred to receive phototherapeutic keratotomy (PTK) for treatment of ... -
Transition to Primary School of Children in Economic Disadvantage: Does a Preschool Teacher Training Program Make a Difference?
(Journal article; Tidsskriftartikkel; Peer reviewed, 2021-07-30)Transition to school may be experienced as a critical event for both children and their families. Within an ecological framework of transition, the scope of the concept of school readiness in recent years has decentered from the child to the environment, including the readiness of (pre)school education to develop core skills in children. This study aims to understand the extent to which preschool ... -
Bruk av kosttilskudd blant apotekkunder
(Mastergradsoppgave; Master thesis, 2020-05-14)Bakgrunn Bruk av kosttilskudd er utbredt over hele verden, og apoteket representerer en salgskanal for denne varegruppen. Det finnes lite forskning om disse produktene, særlig i Norge. Kosttilskudd regnes som næringsmidler, og er dermed ikke regulert på lik linje som legemidler. Dette kan føre til uhensiktsmessig bruk, særlig blant apotekkunder. Disse kan være legemiddelbrukere, hvor en potensiell ... -
Problemer med foreldresamvær i barnevernet- unge voksnes fortellinger
(Journal article; Tidsskriftartikkel; Peer reviewed, 2021-10-14)De fleste som vokser opp i fosterhjem, har kontakt med foreldre, og det iverksettes betydelige ressurser for å gjennomføre foreldresamvær. Dette er i tråd med samværsretten og bygger på kulturelle verdier der relasjonen mellom barn og biologiske foreldre har avgjørende betydning. Forskningslitteraturen kan hevdes å bekrefte viktigheten av foreldresamvær, men viser også at det kan være problematisk. ... -
Epigenetics in Inflammatory Bowel Disease. Contribution of DNA methylation to Ulcerative Colitis pathogenesis
(Doctoral thesis; Doktorgradsavhandling, 2022-04-08)Ulcerative colitis (UC) is a chronic, inflammatory disease of the gastrointestinal tract, primarily affecting the colon. Along with Crohn’s disease (CD) they constitute the most common subtypes of inflammatory bowel disease (IBD). Genetic variants can only explain approximately 20 % of all IBD cases, indicating a more complex pathogenesis which is not fully understood. It has been implied that an ... -
Psychometric Properties and Correlates of Precarious Manhood Beliefs in 62 Nations
(Journal article; Tidsskriftartikkel; Peer reviewed, 2021-03-04)Precarious manhood beliefs portray manhood, relative to womanhood, as a social status that is hard to earn, easy to lose, and proven via public action. Here, we present cross-cultural data on a brief measure of precarious manhood beliefs (the Precarious Manhood Beliefs scale [PMB]) that covaries meaningfully with other cross-culturally validated gender ideologies and with country-level indices of ...