The endothelium is the innermost cell layer of blood vessels and has a key role in maintaining vascular homeostasis. Beside the general role to prevent blood coagulation and regulate blood flow, endothelial cells of different vascular beds show tissue specific specializations. This thesis focuses on a unique endothelial cell with immune-like properties, namely the liver sinusoidal endothelial cell ...

Experiencing flow in physical activity is associated with intrinsic motivation and has proven to be a highly rewarding state of mind (Csikszentmihalyi, 2008). Facilitating flow experiences among regular exercisers can be beneficial in terms of promoting long-term physical activity engagement. In a longitudinal study we explored possible factors predicting flow experiences in exercisers by measuring ...

Formål Det er tidligere vist høyere risiko for død i rurale områder i Norge (2, 3). Paradoksalt er det funnet lavere prevalens av alvorlige, ikke-fatale skader ruralt (3). Vi undersøkte om den økte risikoen for død og lavere prevalens av ikke-fatale skader også gjelder for perioden 2002- 2016, når man bruker Statistisk Sentralitetsbyrås (SSB) sentralitetsindeks som mål for ruralitet. Materiale ...

<i>Objective</i>: Cross-sectional data show that post-traumatic stress disorder (PTSD) patients often have increased levels of circulating inflammatory markers. There is, however, still a paucity of longitudinal studies with long follow-up times on levels of cytokines in such patients. The current study assesses patients with and without PTSD diagnosis 1 year after discharge from inpatient ...

Even though planning is generally helpful in goal pursuit, people do not always choose to plan. The inclination to plan might depend on whether we focus on what we seek to approach or what we seek to avoid. In two pre-registered experiments, we tested the relative effect of approach versus avoidance motivation on willingness to plan (total <i>N</i>=1349). With outcome framing as the experimental ...

The extracellular matrix protein nephronectin plays an important regulatory role during embryonic development, controlling renal organogenesis through integrin α8β1 association. Nephronectin has three main domains: five N-terminal epidermal growth factor-like domains, a linker region harbouring two integrin-binding motifs (RGD and LFEIFEIER), and a C-terminal MAM domain. In this review, we look into ...

Objective - Standardised cancer patient pathways (CPP) are implemented within cancer care with an aim to ensure standardised waiting times for diagnosis and treatment. This article investigates how patients in Norway experience waiting times within a CPP.<p> <p>Methods - Qualitative semi-structured interviews with 19 patients who had been through CPP for breast cancer, prostate cancer or malignant ...

Disruptions in attention, salience and increased distractibility are implicated in multiple psychiatric conditions. The ventral tegmental area (VTA) is a potential site for converging information about external stimuli and internal states to be integrated and guide adaptive behaviours. Given the dual role of dopamine signals in both driving ongoing behaviours (e.g., feeding) and monitoring salient ...

Beskrivelse. Kartlegging av traumeerfaringer og symptomer (KATES Barn) er et screeninginstrument for barn i alderen 7–17 år som gir foreløpig informasjon om mulig posttraumatisk stress. KATES Barn kommer i to deler; del 1 fanger opp traumatiske hendelser, og del 2 måler symptomer på posttraumatisk stress. Del 2 er delt opp i fire symptomkategorier tilpasset de diagnostiske endringene av traumediagnosen ...