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dc.contributor.authorMcKay, James D.
dc.contributor.authorTruong, Therese
dc.contributor.authorGaborieau, V
dc.contributor.authorChabrier, Amelie
dc.contributor.authorChuang, Shu-Chun
dc.contributor.authorByrnes, G
dc.contributor.authorZaridze, D
dc.contributor.authorShangina, O
dc.contributor.authorSzeszenia-Dabrowska, N
dc.contributor.authorLissowska, Jolanta
dc.contributor.authorRudnai, P
dc.contributor.authorFabianova, E
dc.contributor.authorBucur, A
dc.contributor.authorBencko, V
dc.contributor.authorHolcatova, I
dc.contributor.authorJanout, V
dc.contributor.authorForetova, L
dc.contributor.authorLagiou, Pagona
dc.contributor.authorTrichopoulos, Dimitrios
dc.contributor.authorBenhamou, S
dc.contributor.authorAhrens, Wolfgang
dc.contributor.authorBouchardy, C
dc.contributor.authorMerletti, F
dc.contributor.authorRichiardi, L
dc.contributor.authorTalamini, R
dc.contributor.authorSimonato, L
dc.contributor.authorBarzan, L
dc.contributor.authorKjærheim, Kristina
dc.contributor.authorMacfarlane, G
dc.contributor.authorAgudo, Antonio
dc.contributor.authorMacfarlane, Tatiana V.
dc.contributor.authorCanova, C
dc.contributor.authorCastellsague, X
dc.contributor.authorConway, DI
dc.contributor.authorLowry, R
dc.contributor.authorHealy, CM
dc.contributor.authorMcKinney, PA
dc.contributor.authorToner, ME
dc.contributor.authorZnaor, A
dc.contributor.authorMenezes, A
dc.contributor.authorCurado, MP
dc.contributor.authorKoifman, S
dc.contributor.authorNeto, JE
dc.contributor.authorWünsch-Filho, V
dc.contributor.authorBoccia, S
dc.contributor.authorArzani, D
dc.contributor.authorGarrote, LF
dc.contributor.authorCadoni, G
dc.contributor.authorOlshan, AF
dc.contributor.authorWeissler, MC
dc.contributor.authorLuo, JC
dc.contributor.authorFunkhouser, WK
dc.contributor.authorLubinski, Jan
dc.contributor.authorLener, M
dc.contributor.authorTrubicka, J
dc.contributor.authorSchwartz, SM
dc.contributor.authorOszutowska, D
dc.contributor.authorDoody, DR
dc.contributor.authorChen, C
dc.contributor.authorFish, S
dc.contributor.authorLazarus, P
dc.contributor.authorMuscat, JE
dc.contributor.authorGallagher, CJ
dc.contributor.authorZhang, Zuo-Feng
dc.contributor.authorChang, SC
dc.contributor.authorWei, QY
dc.contributor.authorSturgis, EM
dc.contributor.authorFranceschi, S
dc.contributor.authorKelsey, KT
dc.contributor.authorWang, LE
dc.contributor.authorHerrero, R
dc.contributor.authorMarsit, CJ
dc.contributor.authorMcClean, MD
dc.contributor.authorRomkes, M
dc.contributor.authorNelson, HH
dc.contributor.authorBuch, S
dc.contributor.authorNukui, T
dc.contributor.authorZhong, SL
dc.contributor.authorLacko, M
dc.contributor.authorManni, JJ
dc.contributor.authorMcLaughlin, J
dc.contributor.authorHung, RJ
dc.contributor.authorPeters, WHM
dc.contributor.authorVatten, Lars Johan
dc.contributor.authorNjølstad, Inger
dc.contributor.authorGoodman, GE
dc.contributor.authorField, JK
dc.contributor.authorPalli, D
dc.contributor.authorLiloglou, T
dc.contributor.authorClavel-Chapelon, F
dc.contributor.authorVineis, P
dc.contributor.authorKrogh, V
dc.contributor.authorTumino, R
dc.contributor.authorPanico, S
dc.contributor.authorMartinez, Carmen
dc.contributor.authorGonzalez, CA
dc.contributor.authorQuiros, JR
dc.contributor.authorNavarro, C
dc.contributor.authorLarranaga, N
dc.contributor.authorKhaw, KT
dc.contributor.authorArdanaz, E
dc.contributor.authorKey, T
dc.contributor.authorPeeters, PHM
dc.contributor.authorBueno-De-Mesquita, H. Bas
dc.contributor.authorBoeing, H
dc.contributor.authorOvervad, K
dc.contributor.authorTrichopoulou, A
dc.contributor.authorLinseisen, J
dc.contributor.authorHallmans, G
dc.contributor.authorTjønneland, Anne
dc.contributor.authorRiboli, Elio
dc.contributor.authorKumle, Merethe
dc.contributor.authorValk, K
dc.contributor.authorVoodern, Tonu
dc.contributor.authorMetspalu, Andres
dc.contributor.authorBoland, A
dc.contributor.authorZelenika, D
dc.contributor.authorDelepine, M
dc.contributor.authorFoglio, M
dc.contributor.authorLechner, D
dc.contributor.authorBlanché, Hélène
dc.contributor.authorGut, Ivo G.
dc.contributor.authorGalan, P
dc.contributor.authorHashibe, Mia
dc.contributor.authorHeath, Simon
dc.contributor.authorHayes, Richard B.
dc.contributor.authorLathrop, Mark
dc.contributor.authorBoffetta, Paolo
dc.contributor.authorBrennan, Paul
dc.date.accessioned2012-03-21T13:40:04Z
dc.date.available2012-03-21T13:40:04Z
dc.date.issued2011
dc.description.abstractGenome-wide association studies (GWAS) have been successful in identifying common genetic variation involved in susceptibility to etiologically complex disease. We conducted a GWAS to identify common genetic variation involved in susceptibility to upper aero-digestive tract (UADT) cancers. Genome-wide genotyping was carried out using the Illumina HumanHap300 beadchips in 2,091 UADT cancer cases and 3,513 controls from two large European multi-centre UADT cancer studies, as well as 4,821 generic controls. The 19 top-ranked variants were investigated further in an additional 6,514 UADT cancer cases and 7,892 controls of European descent from an additional 13 UADT cancer studies participating in the INHANCE consortium. Five common variants presented evidence for significant association in the combined analysis (p≤5×10−7). Two novel variants were identified, a 4q21 variant (rs1494961, p = 1×10−8) located near DNA repair related genes HEL308 and FAM175A (or Abraxas) and a 12q24 variant (rs4767364, p = 2×10−8) located in an extended linkage disequilibrium region that contains multiple genes including the aldehyde dehydrogenase 2 (ALDH2) gene. Three remaining variants are located in the ADH gene cluster and were identified previously in a candidate gene study involving some of these samples. The association between these three variants and UADT cancers was independently replicated in 5,092 UADT cancer cases and 6,794 controls non-overlapping samples presented here (rs1573496-ADH7, p = 5×10−8; rs1229984-ADH1B, p = 7×10−9; and rs698-ADH1C, p = 0.02). These results implicate two variants at 4q21 and 12q24 and further highlight three ADH variants in UADT cancer susceptibility.en
dc.identifier.citationPLoS Genetics (2011) 7(3): e1001333.en
dc.identifier.cristinIDFRIDAID 840056
dc.identifier.doidoi: 10.1371/journal.pgen.1001333
dc.identifier.issn1553-7390
dc.identifier.urihttps://hdl.handle.net/10037/4033
dc.identifier.urnURN:NBN:no-uit_munin_3754
dc.language.isoengen
dc.publisherPLoS Oneen
dc.rights.accessRightsopenAccess
dc.subjectVDP::Medical disciplines: 700::Basic medical, dental and veterinary science disciplines: 710::Medical genetics: 714en
dc.subjectVDP::Medisinske Fag: 700::Basale medisinske, odontologiske og veterinærmedisinske fag: 710::Medisinsk genetikk: 714en
dc.titleA Genome-Wide Association Study of Upper Aerodigestive Tract Cancers Conducted within the INHANCE Consortiumen
dc.typeJournal articleen
dc.typeTidsskriftartikkelen
dc.typePeer revieweden


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