Doktorgradsavhandlinger (Helsefak): Recent submissions
Now showing items 81-100 of 734
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Cancer drugs as drivers of antibiotic resistance
(Doctoral thesis; Doktorgradsavhandling, 2023-09-15)Antibiotics are the cornerstone for modern medicine, and their introduction into clinical use has made common medical procedures such as surgeries and cancer chemotherapy possible. The consequences of antimicrobial resistance (AMR), if it continues to rise on a global scale at its current speed, are expected to be staggering. It is well-known that antibiotics drive the evolution and spread of AMR, ... -
The transition to motherhood: Maternal well-being and mother-child bonding until four months postpartum. The role of mothers’ early maladaptive schemas, attachment style and the Newborn Behavioral Observation
(Doctoral thesis; Doktorgradsavhandling, 2023-09-21)In this thesis, it was investigated whether mothers` EMSs would predict maternal-fetal bonding quality during pregnancy (paper 1), whether attachment style would be associated with mother-infant bonding quality after birth (paper 2), and if these relations were mediated by symptoms of depression (paper 1) and parenting stress (paper 2). EMSs and anxious and avoidant attachment styles may be thought ... -
Results after surgical treatment of rectal cancer in Norway
(Doctoral thesis; Doktorgradsavhandling, 2023-09-15)Colorectal cancer is the third most common cancer worldwide, and rectal carcinoma represents about 25% of the cases. Surgical removal of the tumor is the standard curative treatment, and during the last decades the survival rates have improved through both better surgical methods and the introduction of radiochemotherapy. There is, however, still an ongoing debate on which treatment offers the best ... -
Cancer associated fibroblasts and their regulatory functions in the context of radiotherapy
(Doctoral thesis; Doktorgradsavhandling, 2023-08-25)<p>Tumours are highly complex tissues comprised of both malignant tumour cells and non-malignant healthy cells. Cells and tissues surrounding solid tumours make out the stroma, which provide physical support to the growing tumour structures, in addition to provide nutrients and facilitate waste removal. In the last four decades, it has become increasingly evident that stromal cells play important ... -
A healthy lifestyle index and cancer: Using a multifactor lifestyle exposure to estimate cancer incidence and survival among Norwegian women
(Doctoral thesis; Doktorgradsavhandling, 2023-08-17)<p><i>Background:</i> Cancer is the leading cause of death in Norway, and lifestyle behaviors are a major contributor to cancer risk. This thesis aimed to investigate the association between a healthy lifestyle index (HLI) and cancer incidence and survival among women in Norway. <p><i>Methods:</i> The study used data from the Norwegian Women and Cancer Study, a national prospective cohort of ... -
"I sound" - yoik as embodied health knowledge
(Doctoral thesis; Doktorgradsavhandling, 2023-08-17)Boares čállosat juoigama ja sámi kultuvrra birra govvidedje juoigama oassin buot eallima beliin sápmelaččas, leaš dál beaivválaš eallima doaimmain dahje vuoiŋŋalaš ja erenoamáš meanuin ja daguin. Juoigan govviduvvui dárbbašlažžan dearvvašvuhtii, čálgui ja lihkkui. Oanehaččat dadjon oažžot lohkat ahte luohti govviduvvui leame eallindárbun. Odne celket máŋga juoigi ahte luođis lea seamma mearkkašumi ... -
The identification of cell type defining genes across human tissues and the functional study of the endothelial adhesion G protein-coupled receptor L4
(Doctoral thesis; Doktorgradsavhandling, 2023-06-30)Cell type specific gene expression profiles underlie differences in cell morphology, behaviour, and specialized function. Single cell RNA sequencing can be used to measure gene expression in individual cells, but challenges remain including limited read-depth, artefactual changes due to dissociation from tissue, difficulties in the analysis of fragile or morphologically complex cell types, and bias ... -
Synthesis and structure-activity relationship studies of marine-derived antimicrobial peptides and small cyclic peptidomimetics
(Doctoral thesis; Doktorgradsavhandling, 2023-06-26)Effective antimicrobial drugs are the very core of modern medicine enabling successful prevention and treatment of infectious diseases. However, systemic misuse and overuse of antibiotics in human medicine, as well as in animal husbandry have led to widespread antibiotic-resistance, rendering many of these drugs ineffective. Therefore, there is an urgent need for new treatment options to conventional ... -
Assessing new prognostic biomarkers in resected colon cancer patients
(Doctoral thesis; Doktorgradsavhandling, 2023-06-22)Colon cancer is a common malignancy. We retrospectively established a biobank including 452 patients operated for colon cancer stage I-III in Northern Norway in the period 1998-2007. Tissue microarrays (TMAs) containing tumor tissue from these patients were constructed, and subsequently biomarker expression assessed by digital pathology. By using in situ hybridization, we assessed the expression of ... -
Anticancer activity of amphipathic barbiturates
(Doctoral thesis; Doktorgradsavhandling, 2023-06-20)Cancer is one of the leading causes of death worldwide. Challenges related to drug resistance, side effects, and poor response rates makes cancer treatment complicated. However, different forms of immunotherapy have been effective for some cancer patients. Oncolytic therapies which can be administered directly intratumorally represent a promising form of immunotherapy. The aim of oncolytic therapies ... -
Why do students leave? Student-related factors and attrition intentions
(Doctoral thesis; Doktorgradsavhandling, 2023-06-20)Established as a collection of scholars protecting their shared interests, higher education has become a driving force of economic development accountable to the government and society. However, changes in higher education have been accompanied by multiple challenges, including funding and quality assessment. This dissertation addresses one of these challenges facing academic institutions, academic ... -
The patient´s role in undergraduate health students' interprofessional clinical placements
(Doctoral thesis; Doktorgradsavhandling, 2023-06-16)Changed demographics and the prevalence of chronic, non-communicable, and infectious diseases create challenges in healthcare - lack of resources forces a transition from one-to-one to team-based approaches. Health professional education must prepare undergraduates for collaborative practice to ensure a collaborative-ready workforce that involves the patient as a partner. Interprofessional education ... -
D-dimer for diagnosis and risk assessment of first and recurrent venous thromboembolism
(Doctoral thesis; Doktorgradsavhandling, 2023-06-15)Venøs tromboembolisme (VTE) er en samlebetegnelse på dyp venetrombose (DVT) og lungeemboli. D-dimer, en blodprøve for koagulasjon og fibrinolyse, har vært en sentral del av VTE-diagnostikken i flere tiår. Blodprøven D-dimer har flere bruksområder og kan dermed reflektere ulike aspekter ved VTE. I denne avhandlingen har vi undersøkt i) om det er trygt og effektivt å bruke D-dimer uten samtidig bruk ... -
Stroke rehabilitation. A mixed method study evaluating a novel physiotherapy intervention and patients’ experiences
(Doctoral thesis; Doktorgradsavhandling, 2023-06-15)In this thesis, the possible benefits and challenges regarding taking part in a comprehensive individualized physiotherapy intervention, called I-CoreDIST and usual care physiotherapy following an acute stroke, along with patient perceptions of participation along the rehabilitation continuum are addressed. This is a mixed method study consisting of a randomised controlled trial (RCT) and an in-depth ... -
Evolutionary genomics of cowpox virus and recombination in vitro between a naturally occurring cowpox virus and a vaccinia virus vectored influenza vaccine
(Doctoral thesis; Doktorgradsavhandling, 2023-06-02)Modified vaccinia virus Ankara (MVA) is a promising orthopoxvirus (OPXV) vector vaccine candidate due to its host range restriction and good safety profile as a smallpox vaccine. It has been widely tested in clinical trials as a recombinant vector for vaccination against infectious diseases and cancers in humans and animals. Furthermore, it is being used as a smallpox and Mpox vaccine. However, the ... -
Physical activity, weight gain, and risk of mortality in adults
(Doctoral thesis; Doktorgradsavhandling, 2023-05-11)<p><i>Why:</i> As low physical activity levels associate with ill health and mortality, continuous monitoring of physical activity levels is needed to inform policy. Identifying aetiology causes for the obesity epidemic is important to prevent population weight gain. However, there are still uncertainties on how physical activity and weight at population level associate over time, and how physical ... -
Persistent Organic Pollutants and Type 2 Diabetes Mellitus. Addressing causality with repeated measurements using novel study designs
(Doctoral thesis; Doktorgradsavhandling, 2023-05-05)<p><i>Background:</i> Persistent Organic Pollutants (POPs) are chemicals that have negative impacts on the environment and biota and have been investigated as possible risk factors for Type 2 Diabetes Mellitus (T2DM). Other well-established risk factors for T2DM, for example, obesity, increased lipids, and age have been reported to influence human POP concentrations. Previous studies have reported ... -
Klebsiella pneumoniae in the marine environment
(Doctoral thesis; Doktorgradsavhandling, 2023-04-26)<p><i>Klebsiella pneumoniae</i> is an opportunistic pathogen present in a wide range of environments. This species is often associated with antibiotic resistance and is a leading cause of health care associated infections but can also cause community acquired infections. Even though <i>K. pneumoniae</i> is extensively studied in clinical settings, less is known about its prevalence, antibiotic ... -
All roads lead to the lysosome: exploring the degradation of TNIP1 by selective autophagy
(Doctoral thesis; Doktorgradsavhandling, 2023-04-21)Selective autophagy is important for maintaining cellular homeostasis. Generally, autophagy is considered cytoprotective and anti-inflammatory, acting to limit infection and accumulation of deleterious material. Key to this function is the ability to select cargo to be degraded, and here, selective autophagy receptors play a central role. In this thesis, we show that the anti-inflammatory and ... -
Dental composites - The effects of matrix composition, suboptimal light curing and water exposure
(Doctoral thesis; Doktorgradsavhandling, 2023-03-30)In Scandinavian countries, resin-based composite materials have been used in restorative dentistry for over 30 years, replacing dental amalgams. Composite materials based on dimethacrylates provide better aesthetics and treatment options. However, according to in-vitro findings, dental composites can be affected by water, potentially reducing the longevity of dental restorations. The proper ...