Summary: The utility of using general practitioners (GPs) in pre-hospital emergency medicine is currently under debate. The aim of this thesis is to examine Norwegian GPs’ contribution and participation in emergency medicine. As there is limited knowledge in this field, we started by conducting focus group interviews with the stakeholders. During the fall 2012 we interviewed emergency technicians ...

Hjerte- og karsykdom er ledende årsak til død og sykelighet på verdensbasis. I Norge er det årlig ca. 13 000 hjerteinfarkt og 12 000 hjerneslag. Til tross for at den forebyggende og akuttmedisinske behandlingen er betydelig forbedret i løpet av de siste 30 år, forventes en fortsatt økning i hjerte- og karsykdommer på verdensbasis. De tradisjonelle risikofaktorene (alder, kjønn, blodtrykk, kolesterol, ...

<p>Birth defects constitute an important public health issue as they are the main causes of perinatal and infant mortality. To address incomplete data coverage in Russia, the studies described in this thesis all have a registry-based study design, and were based on the linkage of the Murmansk County Birth Registry (MCBR) and the Murmansk Regional Congenital Defects Registry (MRCDR) to investigate ...

The use of pulse oximetry and spirometry tests in general practice is increasing. Pulse oximetry is a non-invasive method for measuring oxygen saturation (SpO2). The pulse oximeter is a helpful tool in primary care because it is tolerable for the patient, easy to use and acceptable within the time constraints of a busy practice. Spirometry is used in both diagnosis and monitoring of respiratory ...

In this thesis I present empirical insight to socio-technical challenges of standardising large-scale healthcare information infrastructures (II). The main focus was how to balance the requirements between technological, organizational, and user related requirements in large-scale IIs, as well as the power balance between the actors, and the need for extensive user involvement in such standardization. ...

Background: The aim of this thesis was to explore the association of the cortical architecture of the proximal femoral shaft with non-vertebral fractures. We tested the hypotheses that: (i) cortical parameters are associated with fracture risk independent of Fracture Risk Assessment Tool (FRAX) or Garvan estimates, (ii) women with fractures that are unidentified by FRAX but identified by cortical ...

Today, the majority of testicular cancer patients are cured, and are expected to live 40 to 50 years after treatment. Some of these men experience late effects due to cisplatin treatment, of which second cancer and cardiovascular disease are among the most serious and potentially life threatening. Given the continuously increasing number of cancer survivors, in-depth investigations of treatment-induced ...

<p><i>Background/aims:</i> Acute aortic dissection (AAD) is a rare life-threatening disease that does not easily lend itself to randomized controlled trials. Data regarding the effect of treatment advances in the recent decades is limited. Determinants of follow-up mortality are poorly understood. To include many patients and evaluate contemporary management of AAD, the International Registry ...

Steroid hormones and their receptors are vital for numerous physiological processes in the human body, but also related to the development of several malignancies. One such receptor strongly associated with prostate cancer, is the androgen receptor. Other steroid hormone receptors are also implicated in prostate cancer, their role, however, remains to be defined. Using immunohistochemistry and tissue ...

The present doctoral thesis examines screening and sex differences in autism spectrum disorders (ASD), and how behavioral, developmental and temperamental features of males and females affect early identification of the disorder. The present doctoral thesis found marked sex differences across all three studies, and furthermore found evidence of difficulties at identifying all children with an ASD ...