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norskDoktorgradsavhandlinger (Helsefak): Nye registreringer
Viser treff 601-620 av 713
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Magnetic resonance imaging of pancreatic islets transplantation
(Doctoral thesis; Doktorgradsavhandling, 2012-08-30)Transplanted insulin-producing cells can be safely monitored by magnetic resonance imaging Transplantation of insulin-producing cells can treat patients with diabetes. Unfortunately, the long-term effects of this treatment are poor due to non-survival of the majority of the transplanted cells. In our study, we found that magnetic resonance imaging (MRI) can be safely used to trace survival of the ... -
Nutrients and toxic elements in semidomesticated reindeer in Norway : nutritional and Food Safety Aspects
(Doctoral thesis; Doktorgradsavhandling, 2012-09-28)Reinsdyr (Rangifer tarandus tarandus L.) er en viktig del av samisk kultur og en viktig bestanddel av samisk tradisjonell kost. Data på rein som næringsmiddel for mennesker har vært mangelfulle i forhold andre husdyr. Hovedmålet med denne avhandlingen var å øke kunnskapen om reinsdyr som matvare for mennesker, for å studere konsentrasjoner av fettsyrer, lipider, vitaminer, essensielle elementer ... -
Structure and function of Scaptodrosophila lebanonensis alcohol dehydrogenase
(Doctoral thesis; Doktorgradsavhandling, 2012-09-18)Originating from a fruit fly species, Drosophilid alcohol dehydrogenases enzymes (DADHs) belong to the Short-chain dehydrogenases/reductases (SDR) family. Covering a wide range of species, SDR family members show very similar structure and chemical reaction mechanism. In human there are, so fare, at least 24 SDR enzymes that are connected to diseases. Therefore, understanding the function and chemical ... -
A doctor close at hand : a qualitative analysis of GPs' work in cancer care
(Doctoral thesis; Doktorgradsavhandling, 2012-08-31)Summary of thesis The core of medicine, even specialized and high-tech medicine, is a meeting, a consultation, between a human being asking for advice and another human being, whose knowledge and experience is expected to be helpful. This thesis explores how the suspicion of cancer can arise in such a consultation, how general practitioners (GPs) can contribute to cancer care and how GPs might ... -
Aspects of experimental cooling and rewarming with special reference to accidental hypothermia
(Doctoral thesis; Doktorgradsavhandling, 2012-08-17)Methods and aims We performed open, randomized, placebo-controlled experimental studies in intact, anesthetized pigs with the following main aims: Paper 1 To describe in detail the hemodynamic function with emphasis on left ventricular contractility during surface cooling, steady state severe hypothermia at 25°C, surface rewarming and in the post-hypothermic period of 2 h. Paper 2 1) To ... -
Plasmids, Resistance and Hospital adaptation in Enterococci : an epidemiological approach
(Doctoral thesis; Doktorgradsavhandling, 2012-06-21)Sykehustilpassede bakterier er økende motstandsdyktig mot antibiotika Enterokokker (en type bakterier) er en viktig årsak til infeksjoner man kan få når man er innlagt på sykehus. Enterokokkene spesialiserer seg på å leve i sykehusmiljøet og er ofte er motstandsdyktige mot en rekke antibiotika. Disse bakteriene har en stor evne til å utveksle egenskaper seg i mellom, slik som antibiotika resistens. ... -
LDL apheresis beyond lipid reduction : a study of three different apheresis columns in heterozygous familial hypercholesterolemia and ex vivo
(Doctoral thesis; Doktorgradsavhandling, 2012-06-01)When low density lipoprotein (LDL) cholesterol cannot be adequately controlled by medications, it is possible to reduce LDL-cholesterol by means of LDL apheresis. This extracorporeal treatment is most often used in familial hypercholesterolemia (FH). The procedure is known to reduce LDL-cholesterol significantly. Few studies however, have prospectively and systematically examined how different LDL ... -
Carotid atherosclerosis, vascular risk factors and relation to cognitive test results : the Tromsø study 1994-2008.
(Doctoral thesis; Doktorgradsavhandling, 2012-06-19)The prevalence of dementia and cognitive impairment is rising worldwide as the number of elderly people increases in most countries. Vascular risk factors and carotid artery atherosclerosis have in some epidemiological studies been associated with increased risk of cognitive decline. The carotid artery is essential for blood supply to the brain, but is also vulnerable to atherosclerosis. The ... -
Schizophrenia : gender differences in diagnosis and mortality in admitted patients
(Doctoral thesis; Doktorgradsavhandling, 2012-06-04) -
Renal hyperfiltration, impaired fasting glucose and physical exercise in the general population : a cross-sectional study
(Doctoral thesis; Doktorgradsavhandling, 2012-06-12)Kronisk nyresykdom er vanlig og rammer ca 10 % av befolkningen. Forhøyet blodsukker og insulin ser ut til å gi nyreskade mens fysisk trening kan være beskyttende. Unormalt høy renseevne (filtrasjon) i nyrene, såkalt hyperfiltrasjon, er et fenomen som på sikt antas å gi proteinutskillelse i urinen og etter hvert nedsatt filtrasjon, det vil si kronisk nyresykdom. Hvilke faktorer som bidrar til ... -
Epidemiology and Outcome of Ankylosing Spondylitis in Northern Norway
(Doctoral thesis; Doktorgradsavhandling, 2012-05-29) -
Cardioprotection : focus on Gap Junctions, Hemichannels and Mitochondria
(Doctoral thesis; Doktorgradsavhandling, 2012-05-04)I studiene har vi undersøkt hjerteceller og isolerte hjerter under forhold som ligner på hjerteinfarkt. Denne kunnskapen brukte vi videre til å redusere hjerteinfarkt på rottehjerter. Vi har sett på effekten av hjerteinfarkt på mitokondrier og spesielle kanaler i hjertet som heter gap junctions og halvkanaler. Vi har vist at ved å holde spesielle halvkanaler lukket noen få minutter etter ett ... -
Disease activity and outcome in juvenile idiopathic arthritis - a longitudinal cohort study in the Nordic countries
(Doctoral thesis; Doktorgradsavhandling, 2012-05-16)SUMMARY This thesis is based on the Nordic juvenile idiopathic arthritis (JIA) cohort study. In a multi-centre population-based setting a prospective followup of juvenile idiopathic arthritis (JIA) was performed. Pediatric rheumatology centers in Denmark, Finland, Norway and Sweden included children with newly diagnosed JIA during a 3.5 year period starting January 1st 1997. The study was focused ... -
Psychosocial predictors of an interest in cosmetic surgery : based on a population study of young Norwegian women
(Doctoral thesis; Doktorgradsavhandling, 2012-03-30)This thesis aims to provide more knowledge about psychological and social aspects of cosmetic surgery, in particular what factors are associated with the increased interest in having such surgery oneself. The first paper is angled from a more public health perspective, with focus on what factors predicts whether someone considers having cosmetic surgery in general. In the second paper, the focus ... -
Aspects of health services in Sami areas
(Doctoral thesis; Doktorgradsavhandling, 2012-04-26)Helsepolitikk for samer har bygd på antakelser om at språk- og kulturforskjeller mellom helsepersonell og pasienter fører til et underforbruk av helsetjenester og en dårligere helsetjeneste. Første studie i denne avhandlingen analyserer forbruket av sykehus, og avviser at det er et underforbruk av helsetjenester blant samer generelt, men finner at de eldste innbyggerne i samiske kommuner er noe ... -
The clinical pharmacist's role in post-discharge follow-up of patients with coronary heart disease. A follow-up program.
(Doctoral thesis; Doktorgradsavhandling, 2012-04-13)Coronary heart disease (CHD) is the leading cause of death world-wide. Studies indicate that patients are treated inadequately. Pharmaceutical care programs delivered by pharmacists are known to improve quality of care for patients with a variety of chronic and acute diseases, also CHD. Most of the programs are developed and carried out in the United States and United Kingdom. The overall aim of ... -
Nucleophilic Substitution Reactions for Positron Emission Tomography; Factors Influencing the Reactivity of [18F]Fluoride
(Doctoral thesis; Doktorgradsavhandling, 2012-03-02)Clinical use of positron emission tomography (PET) is expanding from use of [18F]FDG to a wider spectrum of PET-tracers and proprietary PET radiopharmaceuticals. The development of new PET-tracers is however far from trivial and the radiochemistry is a major limiting factor. Nucleophilic substitution reactions with [18F]fluoride generally suffer from inconsistent labeling yields. There is a need to ... -
Clinical and genetic investigations of patients with myotonia congenita in Northern Norway
(Doctoral thesis; Doktorgradsavhandling, 2012-02-10)Femten norske og tre svenske familier med klinisk diagnostisert ’kongenitt myotoni (MC)’ er inkludert i studiet. Alle pasienter likesom deres førstegrads slektninger er undersøkt nøye klinisk og elektromyografisk (EMG). Systematisk undersøkelse av CLCN1 gen er da utført for å finne mutasjoner. Nye mutasjoner blir studert med uttrykks studie for å finne ut deres funksjonelle konsekvens på kanal ... -
Socio-technical integration in health care : a case study from a hospital-based laboratory context.
(Doctoral thesis; Doktorgradsavhandling, 2012-03-30)This thesis deals with socio-technical approaches to the work of implementing ICT systems in health care. In the thesis, I address and reflect on challenges related to design and implementation as well as integration of ICT systems with hospital laboratories. Based upon empirical examples gathered from a longitudinal case study using interpretive methods, the results suggest how health care practices ... -
Clinical and laboratory aspects of vitamin D in relation to type 2 diabetes and osteoporosis. Results from the Tromsø Study and two randomized controlled trials.
(Doctoral thesis; Doktorgradsavhandling, 2011-11-18)There has been a large interest in possible beneficial health effects of increasing the vitamin D (as measured by 25-hydroxyvitamin D (25(OH)D)) levels in the population. Data from the Tromsø Study were used to assess the relation between serum 25(OH)D levels and the risk of subsequent type 2 diabetes in 6119 participants. This risk was approximately doubled in the lowest serum 25(OH)D quartile as ...
